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• W2068361488 abstract "A tandem simulated moving bed (SMB) process, which consists of two SMBs in series, was developed for insulin purification in a previous study (Xie, Y.; Mun, S.-Y.; Kim, J.-H.; Wang, N.-H. L. Biotechnol. Prog. 2002, 18, 1332). A conventional startup procedure required a period of 12 h for the first SMB and 46 h for the second SMB to reach cyclic steady state. In this study, a startup strategy with pre-loading and pre-elution steps has been developed to reduce the startup period to 2 h for the first SMB and 5 h for the second SMB. The transient dynamics of the SMB shutdown process was also studied for the first time. A new shutdown strategy has also been developed to recover more than 99% of the remaining insulin during shutdown. The startup and shutdown strategies are verified with results from computer simulations and validated with experimental data." @default.
• W2068361488 created "2016-06-24" @default.
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• W2068361488 date "2003-03-04" @default.
• W2068361488 modified "2023-09-27" @default.
• W2068361488 title "Startup and Shutdown Strategies of Simulated Moving Bed for Insulin Purification" @default.
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• W2068361488 doi "https://doi.org/10.1021/ie020674d" @default.
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