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• W2068361653 abstract "A series of new 2,4-diarylaminopyrimidine analogues (DAAPalogues) was developed by incorporation of a substituted 2-aminothiazole component as the C-2 substituent of the center pyrimidine core. Compound 5i showed highest potency of 12.4 nM against ALK and 24.1 nM against ALK gatekeeper mutation L1196M. Although only having moderate cellular potency in the SUP-M2 cells harboring NPM-ALK, compound 5i showed good kinase selectivity and dose-dependently inhibited phosphorylation of ALK and its down-stream signaling pathways." @default.
• W2068361653 created "2016-06-24" @default.
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• W2068361653 date "2014-10-01" @default.
• W2068361653 modified "2023-09-26" @default.
• W2068361653 title "Design, synthesis and pharmacological evaluation of 2-(thiazol-2-amino)-4-arylaminopyrimidines as potent anaplastic lymphoma kinase (ALK) inhibitors" @default.
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• W2068361653 doi "https://doi.org/10.1016/j.ejmech.2014.09.003" @default.
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