FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2068361753> ?p ?o ?g. }

• W2068361753 endingPage "320" @default.
• W2068361753 startingPage "309" @default.
• W2068361753 abstract "The influence of vitamins E and C on the initial stages of lipid peroxidation in human erythrocyte membranes was assessed with the fluorescent polyunsaturated fatty acid, parinaric acid, as probe molecule. Cumene hydroperoxide was used as initiator with either haemin-Fe3+ or Cu2+ as metal ion cofactor. The effect of vitamin C (pro- or antioxidant) appeared to be determined by the localisation of the metal ions, either in the water phase or in the membrane. Vitamin C is only able to reduce metal ions in the water phase, which results in acceleration of radical generation and subsequent enhancement of parinaric acid peroxidation. Thus, interaction of vitamin C with Cu2+ in the water phase led to drastically enhanced peroxidation of parinaric acid. In contrast, when only membrane-associated haemin-Fe3+ was present, vitamin C functioned as an antioxidant at all concentrations tested (0-10 microM). In a system with haemin-Fe3+ equilibrated between the water phase and the membranes, less than 5 microM vitamin C produced an overall prooxidant, and greater than 15 microM vitamin C an overall antioxidant effect. At vitamin C concentrations of 5-15 microM, continuous measurement of parinaric acid fluorescence revealed a shift in the vitamin C effect from antioxidant to prooxidant within the time-course of an assay. Vitamin E exhibited a protective effect on peroxidation initiated by cumene (per)oxyl radicals with haemin-Fe3+ as cofactor, by inducing a concentration-dependent extension of the lag-phase in parinaric acid peroxidation. Vitamin E appeared to be much more effective compared with vitamin C in scavenging radicals in this system. This indicates that vitamin C has only a limited ability to react with cumene (per)oxyl radicals in the membrane. The combination of vitamins E and C produced a protective effect on parinaric acid peroxidation exceeding the sum of their individual contributions. Moreover, the rate of vitamin E consumption was drastically lowered in the presence of vitamin C, whereas the rate of vitamin C consumption hardly decreased in the presence of vitamin E. The results are discussed in terms of a reaction scheme where the relative contributions of a number of reactions are considered to determine the total effect of added vitamin C or E. Vitamin E radicals constitute an additional substrate for vitamin C, resulting in a more than additive shift in the overall effect to the antioxidant side." @default.
• W2068361753 created "2016-06-24" @default.
• W2068361753 creator A5025713708 @default.
• W2068361753 creator A5047162260 @default.
• W2068361753 creator A5076443395 @default.
• W2068361753 creator A5077818538 @default.
• W2068361753 date "1990-03-01" @default.
• W2068361753 modified "2023-10-17" @default.
• W2068361753 title "The cooperative action of vitamins E and C in the protection against peroxidation of parinaric acid in human erythrocyte membranes" @default.
• W2068361753 cites W1536422318 @default.
• W2068361753 cites W1552806232 @default.
• W2068361753 cites W1963820921 @default.
• W2068361753 cites W1969167841 @default.
• W2068361753 cites W1971261065 @default.
• W2068361753 cites W1982568803 @default.
• W2068361753 cites W1992697830 @default.
• W2068361753 cites W1996253777 @default.
• W2068361753 cites W2003709444 @default.
• W2068361753 cites W2007140957 @default.
• W2068361753 cites W2008836533 @default.
• W2068361753 cites W2011492430 @default.
• W2068361753 cites W2014367789 @default.
• W2068361753 cites W2017851819 @default.
• W2068361753 cites W2026304182 @default.
• W2068361753 cites W2029684018 @default.
• W2068361753 cites W2034467957 @default.
• W2068361753 cites W2035635392 @default.
• W2068361753 cites W2037663075 @default.
• W2068361753 cites W2039108603 @default.
• W2068361753 cites W2047610618 @default.
• W2068361753 cites W2048385321 @default.
• W2068361753 cites W2052664734 @default.
• W2068361753 cites W2064313935 @default.
• W2068361753 cites W2073656221 @default.
• W2068361753 cites W2091201487 @default.
• W2068361753 cites W2115303076 @default.
• W2068361753 cites W2126811697 @default.
• W2068361753 cites W2168561333 @default.
• W2068361753 cites W2180979328 @default.
• W2068361753 cites W2186595494 @default.
• W2068361753 cites W315541072 @default.
• W2068361753 doi "https://doi.org/10.1016/0009-3084(90)90028-p" @default.
• W2068361753 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2340603" @default.
• W2068361753 hasPublicationYear "1990" @default.
• W2068361753 type Work @default.
• W2068361753 sameAs 2068361753 @default.
• W2068361753 citedByCount "60" @default.
• W2068361753 countsByYear W20683617532014 @default.
• W2068361753 countsByYear W20683617532015 @default.
• W2068361753 countsByYear W20683617532017 @default.
• W2068361753 countsByYear W20683617532020 @default.
• W2068361753 countsByYear W20683617532021 @default.
• W2068361753 crossrefType "journal-article" @default.
• W2068361753 hasAuthorship W2068361753A5025713708 @default.
• W2068361753 hasAuthorship W2068361753A5047162260 @default.
• W2068361753 hasAuthorship W2068361753A5076443395 @default.
• W2068361753 hasAuthorship W2068361753A5077818538 @default.
• W2068361753 hasConcept C161790260 @default.
• W2068361753 hasConcept C185592680 @default.
• W2068361753 hasConcept C2776940978 @default.
• W2068361753 hasConcept C2777551382 @default.
• W2068361753 hasConcept C2778004101 @default.
• W2068361753 hasConcept C2778113725 @default.
• W2068361753 hasConcept C2780022331 @default.
• W2068361753 hasConcept C2780829032 @default.
• W2068361753 hasConcept C2986274086 @default.
• W2068361753 hasConcept C31903555 @default.
• W2068361753 hasConcept C41625074 @default.
• W2068361753 hasConcept C55493867 @default.
• W2068361753 hasConceptScore W2068361753C161790260 @default.
• W2068361753 hasConceptScore W2068361753C185592680 @default.
• W2068361753 hasConceptScore W2068361753C2776940978 @default.
• W2068361753 hasConceptScore W2068361753C2777551382 @default.
• W2068361753 hasConceptScore W2068361753C2778004101 @default.
• W2068361753 hasConceptScore W2068361753C2778113725 @default.
• W2068361753 hasConceptScore W2068361753C2780022331 @default.
• W2068361753 hasConceptScore W2068361753C2780829032 @default.
• W2068361753 hasConceptScore W2068361753C2986274086 @default.
• W2068361753 hasConceptScore W2068361753C31903555 @default.
• W2068361753 hasConceptScore W2068361753C41625074 @default.
• W2068361753 hasConceptScore W2068361753C55493867 @default.
• W2068361753 hasIssue "4" @default.
• W2068361753 hasLocation W20683617531 @default.
• W2068361753 hasLocation W20683617532 @default.
• W2068361753 hasOpenAccess W2068361753 @default.
• W2068361753 hasPrimaryLocation W20683617531 @default.
• W2068361753 hasRelatedWork W1687510487 @default.
• W2068361753 hasRelatedWork W1993747925 @default.
• W2068361753 hasRelatedWork W2069460849 @default.
• W2068361753 hasRelatedWork W2143233376 @default.
• W2068361753 hasRelatedWork W2169892970 @default.
• W2068361753 hasRelatedWork W2352833908 @default.
• W2068361753 hasRelatedWork W2432277451 @default.
• W2068361753 hasRelatedWork W4323344942 @default.
• W2068361753 hasRelatedWork W72840072 @default.
• W2068361753 hasRelatedWork W94127714 @default.
• W2068361753 hasVolume "53" @default.
• W2068361753 isParatext "false" @default.

• next