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- W2068362557 endingPage "9" @default.
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- W2068362557 abstract "Protein kinase A (PKA) is a serine/threonine kinase that regulates a number of cellular processes important for immune activation and control. Modulation of signal transduction by PKA is a complex and diverse process, and differential isozyme expression, holoenzyme composition and subcellular localization contribute specificity to the PKA signalling pathway. In lymphocytes, phosphorylation by PKA has been demonstrated to regulate antigen receptor-induced signalling both by altering protein-protein interactions and by changing the enzymatic activity of target proteins. PKA substrates involved in immune activation include transcription factors, members of the MAP kinase pathway and phospholipases. The ability of PKA type I to regulate activation of signalling components important for formation of the immunological synapse, demonstrates that the cAMP signalling pathway can directly modulate proximal events in lymphocyte activation. Furthermore, the recent discovery that PKA regulates Src kinases through modulation of Csk, supports the notion that PKA is involved in the fine-tuning of immune receptor signalling in lipid rafts." @default.
- W2068362557 created "2016-06-24" @default.
- W2068362557 creator A5012199633 @default.
- W2068362557 creator A5023584302 @default.
- W2068362557 creator A5036465328 @default.
- W2068362557 creator A5042862730 @default.
- W2068362557 creator A5064888516 @default.
- W2068362557 date "2002-01-01" @default.
- W2068362557 modified "2023-10-16" @default.
- W2068362557 title "Molecular mechanisms for protein kinase A-mediated modulation of immune function" @default.
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