Matches in SemOpenAlex for { <https://semopenalex.org/work/W2068363048> ?p ?o ?g. }
- W2068363048 endingPage "e1001819" @default.
- W2068363048 startingPage "e1001819" @default.
- W2068363048 abstract "Jumonji domain-containing 6 (JMJD6) is a member of the Jumonji C domain-containing family of proteins. Compared to other members of the family, the cellular activity of JMJD6 is still not clearly defined and its biological function is still largely unexplored. Here we report that JMJD6 is physically associated with the tumor suppressor p53. We demonstrated that JMJD6 acts as an α-ketoglutarate- and Fe(II)-dependent lysyl hydroxylase to catalyze p53 hydroxylation. We found that p53 indeed exists as a hydroxylated protein in vivo and that the hydroxylation occurs mainly on lysine 382 of p53. We showed that JMJD6 antagonizes p53 acetylation, promotes the association of p53 with its negative regulator MDMX, and represses transcriptional activity of p53. Depletion of JMJD6 enhances p53 transcriptional activity, arrests cells in the G1 phase, promotes cell apoptosis, and sensitizes cells to DNA damaging agent-induced cell death. Importantly, knockdown of JMJD6 represses p53-dependent colon cell proliferation and tumorigenesis in vivo, and significantly, the expression of JMJD6 is markedly up-regulated in various types of human cancer especially in colon cancer, and high nuclear JMJD6 protein is strongly correlated with aggressive clinical behaviors of colon adenocarcinomas. Our results reveal a novel posttranslational modification for p53 and support the pursuit of JMJD6 as a potential biomarker for colon cancer aggressiveness and a potential target for colon cancer intervention." @default.
- W2068363048 created "2016-06-24" @default.
- W2068363048 creator A5004356931 @default.
- W2068363048 creator A5007865045 @default.
- W2068363048 creator A5020713025 @default.
- W2068363048 creator A5025436913 @default.
- W2068363048 creator A5037083055 @default.
- W2068363048 creator A5041744833 @default.
- W2068363048 creator A5042500482 @default.
- W2068363048 creator A5046265881 @default.
- W2068363048 creator A5050622568 @default.
- W2068363048 creator A5055765857 @default.
- W2068363048 creator A5057741217 @default.
- W2068363048 creator A5058445239 @default.
- W2068363048 creator A5058749160 @default.
- W2068363048 creator A5083074324 @default.
- W2068363048 creator A5083670515 @default.
- W2068363048 creator A5090524149 @default.
- W2068363048 date "2014-03-25" @default.
- W2068363048 modified "2023-10-18" @default.
- W2068363048 title "JMJD6 Promotes Colon Carcinogenesis through Negative Regulation of p53 by Hydroxylation" @default.
- W2068363048 cites W1906028746 @default.
- W2068363048 cites W1970993216 @default.
- W2068363048 cites W1973734373 @default.
- W2068363048 cites W1976873804 @default.
- W2068363048 cites W1977497204 @default.
- W2068363048 cites W1978518304 @default.
- W2068363048 cites W1982162367 @default.
- W2068363048 cites W1982545065 @default.
- W2068363048 cites W1983939040 @default.
- W2068363048 cites W1997388033 @default.
- W2068363048 cites W2004681996 @default.
- W2068363048 cites W2006313701 @default.
- W2068363048 cites W2007249806 @default.
- W2068363048 cites W2008301561 @default.
- W2068363048 cites W2010611789 @default.
- W2068363048 cites W2011892634 @default.
- W2068363048 cites W2013004928 @default.
- W2068363048 cites W2014196410 @default.
- W2068363048 cites W2015933637 @default.
- W2068363048 cites W2017488005 @default.
- W2068363048 cites W2017673293 @default.
- W2068363048 cites W2025476423 @default.
- W2068363048 cites W2025722611 @default.
- W2068363048 cites W2032594275 @default.
- W2068363048 cites W2034156554 @default.
- W2068363048 cites W2049436772 @default.
- W2068363048 cites W2051907464 @default.
- W2068363048 cites W2056530510 @default.
- W2068363048 cites W2060972565 @default.
- W2068363048 cites W2071694775 @default.
- W2068363048 cites W2073936529 @default.
- W2068363048 cites W2074545297 @default.
- W2068363048 cites W2076057425 @default.
- W2068363048 cites W2076411120 @default.
- W2068363048 cites W2079706088 @default.
- W2068363048 cites W2080758856 @default.
- W2068363048 cites W2080954244 @default.
- W2068363048 cites W2081184407 @default.
- W2068363048 cites W2081204899 @default.
- W2068363048 cites W2082979850 @default.
- W2068363048 cites W2089230506 @default.
- W2068363048 cites W2089574530 @default.
- W2068363048 cites W2092722802 @default.
- W2068363048 cites W2096807498 @default.
- W2068363048 cites W2098504555 @default.
- W2068363048 cites W2102625800 @default.
- W2068363048 cites W2114874351 @default.
- W2068363048 cites W2115862579 @default.
- W2068363048 cites W2116590830 @default.
- W2068363048 cites W2116755440 @default.
- W2068363048 cites W2118411078 @default.
- W2068363048 cites W2120921507 @default.
- W2068363048 cites W2131317966 @default.
- W2068363048 cites W2131523916 @default.
- W2068363048 cites W2131640657 @default.
- W2068363048 cites W2135369267 @default.
- W2068363048 cites W2141576639 @default.
- W2068363048 cites W2143238860 @default.
- W2068363048 cites W2145141598 @default.
- W2068363048 cites W2169801567 @default.
- W2068363048 cites W4212962560 @default.
- W2068363048 doi "https://doi.org/10.1371/journal.pbio.1001819" @default.
- W2068363048 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3965384" @default.
- W2068363048 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24667498" @default.
- W2068363048 hasPublicationYear "2014" @default.
- W2068363048 type Work @default.
- W2068363048 sameAs 2068363048 @default.
- W2068363048 citedByCount "109" @default.
- W2068363048 countsByYear W20683630482013 @default.
- W2068363048 countsByYear W20683630482014 @default.
- W2068363048 countsByYear W20683630482015 @default.
- W2068363048 countsByYear W20683630482016 @default.
- W2068363048 countsByYear W20683630482017 @default.
- W2068363048 countsByYear W20683630482018 @default.
- W2068363048 countsByYear W20683630482019 @default.
- W2068363048 countsByYear W20683630482020 @default.
- W2068363048 countsByYear W20683630482021 @default.