Matches in SemOpenAlex for { <https://semopenalex.org/work/W2068363516> ?p ?o ?g. }
Showing items 1 to 70 of
70
with 100 items per page.
- W2068363516 endingPage "199" @default.
- W2068363516 startingPage "187" @default.
- W2068363516 abstract "The long-term antihypertensive efficacy and tolerability of a controlled-release (coat core [CC]) tablet formulation of nisoldipine, a second-generation dihydropyridine calcium-channel blocker, was evaluated in three open-label, multicenter trials of up to 1 year in duration. A total of 365 patients with mild-to-moderate essential hypertension received nisoldipine CC 10 mg, 20 mg, 30 mg, or 40 mg once daily, with or without concomitant antihypertensive therapies. Blood pressure measurements (supine and standing, both diastolic and systolic) were taken at baseline; at weeks 2, 4, and 6; and then at 1- or 2-month intervals for up to 1 year. Adverse events were also monitored. During short-term therapy, nisoldipine CC produced a clinically significant reduction in blood pressure, which was maintained throughout the 1-year treatment period. Nisoldipine CC was effective in a broad range of patients, including the elderly and young adults, men and women, and nonwhite and white patients. Overall, treatment was well tolerated and there were no changes in metabolic variables following long-term treatment with nisoldipine CC. Adverse events, which were generally mild and transient, were the type usually associated with the dihydropyridine class of calcium-channel blockers. There were no clinically relevant changes in heart rate with nisoldipine CC therapy. This study suggests that nisoldipine CC is effective and well tolerated as long-term treatment for mild-to-moderate hypertension. When used in short-term therapy, it produces a clinically relevant reduction in blood pressure, which is maintained during longer treatment periods." @default.
- W2068363516 created "2016-06-24" @default.
- W2068363516 creator A5014285484 @default.
- W2068363516 date "1997-03-01" @default.
- W2068363516 modified "2023-09-23" @default.
- W2068363516 title "The long-term efficacy and tolerability of nisoldipine in patients with mild-to-moderate hypertension" @default.
- W2068363516 cites W2010482372 @default.
- W2068363516 cites W2033387649 @default.
- W2068363516 cites W2049192423 @default.
- W2068363516 cites W2057793243 @default.
- W2068363516 cites W2085710891 @default.
- W2068363516 cites W2088756925 @default.
- W2068363516 cites W2148711324 @default.
- W2068363516 cites W2163097906 @default.
- W2068363516 cites W3187484159 @default.
- W2068363516 cites W4294294191 @default.
- W2068363516 doi "https://doi.org/10.1016/s0011-393x(97)80014-8" @default.
- W2068363516 hasPublicationYear "1997" @default.
- W2068363516 type Work @default.
- W2068363516 sameAs 2068363516 @default.
- W2068363516 citedByCount "3" @default.
- W2068363516 crossrefType "journal-article" @default.
- W2068363516 hasAuthorship W2068363516A5014285484 @default.
- W2068363516 hasConcept C125567185 @default.
- W2068363516 hasConcept C126322002 @default.
- W2068363516 hasConcept C164705383 @default.
- W2068363516 hasConcept C197934379 @default.
- W2068363516 hasConcept C2776271655 @default.
- W2068363516 hasConcept C2777097880 @default.
- W2068363516 hasConcept C2777953023 @default.
- W2068363516 hasConcept C2778375690 @default.
- W2068363516 hasConcept C2779066535 @default.
- W2068363516 hasConcept C2781212610 @default.
- W2068363516 hasConcept C519063684 @default.
- W2068363516 hasConcept C71924100 @default.
- W2068363516 hasConcept C84393581 @default.
- W2068363516 hasConceptScore W2068363516C125567185 @default.
- W2068363516 hasConceptScore W2068363516C126322002 @default.
- W2068363516 hasConceptScore W2068363516C164705383 @default.
- W2068363516 hasConceptScore W2068363516C197934379 @default.
- W2068363516 hasConceptScore W2068363516C2776271655 @default.
- W2068363516 hasConceptScore W2068363516C2777097880 @default.
- W2068363516 hasConceptScore W2068363516C2777953023 @default.
- W2068363516 hasConceptScore W2068363516C2778375690 @default.
- W2068363516 hasConceptScore W2068363516C2779066535 @default.
- W2068363516 hasConceptScore W2068363516C2781212610 @default.
- W2068363516 hasConceptScore W2068363516C519063684 @default.
- W2068363516 hasConceptScore W2068363516C71924100 @default.
- W2068363516 hasConceptScore W2068363516C84393581 @default.
- W2068363516 hasIssue "3" @default.
- W2068363516 hasLocation W20683635161 @default.
- W2068363516 hasOpenAccess W2068363516 @default.
- W2068363516 hasPrimaryLocation W20683635161 @default.
- W2068363516 hasRelatedWork W1514854093 @default.
- W2068363516 hasRelatedWork W2004716117 @default.
- W2068363516 hasRelatedWork W2050130494 @default.
- W2068363516 hasRelatedWork W2085710891 @default.
- W2068363516 hasRelatedWork W2119698783 @default.
- W2068363516 hasRelatedWork W2395549830 @default.
- W2068363516 hasRelatedWork W3046428350 @default.
- W2068363516 hasRelatedWork W59183110 @default.
- W2068363516 hasRelatedWork W73303660 @default.
- W2068363516 hasRelatedWork W82813214 @default.
- W2068363516 hasVolume "58" @default.
- W2068363516 isParatext "false" @default.
- W2068363516 isRetracted "false" @default.
- W2068363516 magId "2068363516" @default.
- W2068363516 workType "article" @default.