Matches in SemOpenAlex for { <https://semopenalex.org/work/W2068365625> ?p ?o ?g. }
- W2068365625 endingPage "3450" @default.
- W2068365625 startingPage "3444" @default.
- W2068365625 abstract "The 1,3-dipolar cycloaddition of nitrile oxides generated in situ from benzohydroximinoyl chloride and triethylamine to 2-aminopyranopyridine-3-carbonitriles and 2-aminochromene-3-carbonitriles occurred chemoselectively furnishing novel 1,2,4-oxadiazole-pyranopyridine/chromene hybrid heterocycles in moderate yields. In vitro screening of these compounds against Mycobacterium tuberculosis H37Rv (MTB) disclosed that the 1,2,4-oxadiazole-pyranopyridine hybrids display enhanced activity relative to the 1,2,4-oxadiazole-chromene hybrids. Among the compounds screened, 3-[3-(4-chlorophenyl)-1,2,4-oxadiazol-5-yl]-4-(2,4-dichlorophenyl)-8-[(E)-(2,4-dichlorophenyl)-methylidene]-6-methyl-5,6,7,8-tetrahydro-4H-pyrano[3,2-c]pyridin-2-amine (MIC: 0.31 μM) is 1.2, 15.2 and 24.6 times more active than standard antitubercular drugs, viz. isoniazid, ciprofloxacin and ethambutol, respectively." @default.
- W2068365625 created "2016-06-24" @default.
- W2068365625 creator A5037562938 @default.
- W2068365625 creator A5055370602 @default.
- W2068365625 creator A5081462848 @default.
- W2068365625 creator A5085931640 @default.
- W2068365625 creator A5088082485 @default.
- W2068365625 date "2011-06-01" @default.
- W2068365625 modified "2023-10-18" @default.
- W2068365625 title "Antimycobacterial activity of novel 1,2,4-oxadiazole-pyranopyridine/chromene hybrids generated by chemoselective 1,3-dipolar cycloadditions of nitrile oxides" @default.
- W2068365625 cites W1967037336 @default.
- W2068365625 cites W1967783487 @default.
- W2068365625 cites W1968397983 @default.
- W2068365625 cites W1975162087 @default.
- W2068365625 cites W1979273900 @default.
- W2068365625 cites W1986155834 @default.
- W2068365625 cites W1993178355 @default.
- W2068365625 cites W1995111489 @default.
- W2068365625 cites W1996808708 @default.
- W2068365625 cites W2008475060 @default.
- W2068365625 cites W2013275050 @default.
- W2068365625 cites W2017880449 @default.
- W2068365625 cites W2023435362 @default.
- W2068365625 cites W2032235244 @default.
- W2068365625 cites W2035790116 @default.
- W2068365625 cites W2042827461 @default.
- W2068365625 cites W2066318486 @default.
- W2068365625 cites W2067650781 @default.
- W2068365625 cites W2067712172 @default.
- W2068365625 cites W2068692138 @default.
- W2068365625 cites W2073918060 @default.
- W2068365625 cites W2076867497 @default.
- W2068365625 cites W2085075705 @default.
- W2068365625 cites W2087525705 @default.
- W2068365625 cites W2090481685 @default.
- W2068365625 cites W2114320654 @default.
- W2068365625 cites W2130430412 @default.
- W2068365625 cites W2133126004 @default.
- W2068365625 cites W2162106505 @default.
- W2068365625 cites W2174059884 @default.
- W2068365625 cites W2951693712 @default.
- W2068365625 cites W2952018815 @default.
- W2068365625 doi "https://doi.org/10.1016/j.bmc.2011.04.033" @default.
- W2068365625 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21592801" @default.
- W2068365625 hasPublicationYear "2011" @default.
- W2068365625 type Work @default.
- W2068365625 sameAs 2068365625 @default.
- W2068365625 citedByCount "53" @default.
- W2068365625 countsByYear W20683656252012 @default.
- W2068365625 countsByYear W20683656252013 @default.
- W2068365625 countsByYear W20683656252014 @default.
- W2068365625 countsByYear W20683656252015 @default.
- W2068365625 countsByYear W20683656252016 @default.
- W2068365625 countsByYear W20683656252017 @default.
- W2068365625 countsByYear W20683656252018 @default.
- W2068365625 countsByYear W20683656252019 @default.
- W2068365625 countsByYear W20683656252020 @default.
- W2068365625 countsByYear W20683656252021 @default.
- W2068365625 countsByYear W20683656252022 @default.
- W2068365625 countsByYear W20683656252023 @default.
- W2068365625 crossrefType "journal-article" @default.
- W2068365625 hasAuthorship W2068365625A5037562938 @default.
- W2068365625 hasAuthorship W2068365625A5055370602 @default.
- W2068365625 hasAuthorship W2068365625A5081462848 @default.
- W2068365625 hasAuthorship W2068365625A5085931640 @default.
- W2068365625 hasAuthorship W2068365625A5088082485 @default.
- W2068365625 hasConcept C142724271 @default.
- W2068365625 hasConcept C155647269 @default.
- W2068365625 hasConcept C161790260 @default.
- W2068365625 hasConcept C178790620 @default.
- W2068365625 hasConcept C185592680 @default.
- W2068365625 hasConcept C21951064 @default.
- W2068365625 hasConcept C2775843808 @default.
- W2068365625 hasConcept C2776228421 @default.
- W2068365625 hasConcept C2777419590 @default.
- W2068365625 hasConcept C2777975735 @default.
- W2068365625 hasConcept C2779240715 @default.
- W2068365625 hasConcept C2779448499 @default.
- W2068365625 hasConcept C2779664164 @default.
- W2068365625 hasConcept C2779685592 @default.
- W2068365625 hasConcept C2781069245 @default.
- W2068365625 hasConcept C2781283055 @default.
- W2068365625 hasConcept C501593827 @default.
- W2068365625 hasConcept C55493867 @default.
- W2068365625 hasConcept C71240020 @default.
- W2068365625 hasConcept C71924100 @default.
- W2068365625 hasConceptScore W2068365625C142724271 @default.
- W2068365625 hasConceptScore W2068365625C155647269 @default.
- W2068365625 hasConceptScore W2068365625C161790260 @default.
- W2068365625 hasConceptScore W2068365625C178790620 @default.
- W2068365625 hasConceptScore W2068365625C185592680 @default.
- W2068365625 hasConceptScore W2068365625C21951064 @default.
- W2068365625 hasConceptScore W2068365625C2775843808 @default.
- W2068365625 hasConceptScore W2068365625C2776228421 @default.
- W2068365625 hasConceptScore W2068365625C2777419590 @default.
- W2068365625 hasConceptScore W2068365625C2777975735 @default.
- W2068365625 hasConceptScore W2068365625C2779240715 @default.
- W2068365625 hasConceptScore W2068365625C2779448499 @default.