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- W2068366872 abstract "Significance Polycyclic aromatic hydrocarbons (PAHs) constitute a class of well-characterized environmental pollutants. Benzo[ a ]pyrene (BP), a typical and extensively studied PAH, can be metabolically converted to mutagenic reactive intermediates in vivo to form the major 10 S (+)- trans - anti -BP diol epoxide (BPDE)- N 2 -dG (BPDE-dG) lesions and thus impede DNA replication and enhance mutagenesis. DNA polymerase κ (Polκ) is the only known DNA polymerase in mouse or human cells that can bypass the BPDE-dG adduct in an error free manner, thereby reducing mutation risk. Here we show that a structural gap and the N-clasp of Polκ are essential for accurate translesion synthesis of the bulky adduct." @default.
- W2068366872 created "2016-06-24" @default.
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- W2068366872 date "2014-01-21" @default.
- W2068366872 modified "2023-10-12" @default.
- W2068366872 title "Variants of mouse DNA polymerase κ reveal a mechanism of efficient and accurate translesion synthesis past a benzo[ <i>a</i> ]pyrene dG adduct" @default.
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- W2068366872 doi "https://doi.org/10.1073/pnas.1324168111" @default.
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