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• W2068368081 abstract "The neuroendocrine response to stress utilizes several bio-communicative pathways which also play a role in neurodevelopmental plasticity. The mechanism of action of steroidal compounds includes DNA alteration by reactive oxygen species (ROS) arising through redox cycling of reactive hormone derivatives. ROS and reactive nitrogen species play a significant role in signaling networks affecting gene transcriptional regulation during normal as well as stress-induced responses. ROS-associated synaptic and regulatory region plasticity may have been important for normal brain evolution, but probably simultaneously lowered the threshold for inducing neuropathology. A shift from 'plasticity' to 'instability' is likely to be associated with the emergence of complex effects depending on the timing, duration and intensity of the ROS insult, and is suggested to include heritable epigenetic chromatin/regulatory region remodeling differentially influencing expression levels of significant neuropsychiatric genes and their variant alleles. Neurobehavioural disorder clinical manifestations have been linked with ROS effects. The concepts discussed here relate to ROS-associated instability of DNA regulatory region sequences and a proposal that it may play an important modifying role in brain and neuro-behaviourally related gene expression. Genes encoding key steps in mitochondrial, haem, iron and bilirubin ROS metabolic pathways have been used as examples to illustrate how ROS-modified regulatory networks could possibly alter the context within which (even ostensibly unrelated) neuropsychiatric gene candidates may sometimes be recruited. Furthermore, reactions of certain radicals release sufficient energy to generate UV-photons. DNA conformational changes accompanied by changes in photon emission suggest that functional neuroimaging findings probably reflect interaction on the level of ROS/biophoton/genome regulatory region domains rather than the signatures of individual neurobehavioural disorder candidate genes." @default.
• W2068368081 created "2016-06-24" @default.
• W2068368081 creator A5071584034 @default.
• W2068368081 date "2006-01-01" @default.
• W2068368081 modified "2023-09-25" @default.
• W2068368081 title "Reactive oxygen species and related haem pathway components as possible epigenetic modifiers in neurobehavioural pathology" @default.
• W2068368081 cites W146728166 @default.
• W2068368081 cites W1542898773 @default.
• W2068368081 cites W179312103 @default.
• W2068368081 cites W1961040664 @default.
• W2068368081 cites W1967152293 @default.
• W2068368081 cites W1971566517 @default.
• W2068368081 cites W1972355020 @default.
• W2068368081 cites W1977844234 @default.
• W2068368081 cites W1978123641 @default.
• W2068368081 cites W1982811255 @default.
• W2068368081 cites W1983324034 @default.
• W2068368081 cites W1983809003 @default.
• W2068368081 cites W1983939607 @default.
• W2068368081 cites W1987272843 @default.
• W2068368081 cites W1989041122 @default.
• W2068368081 cites W1990250378 @default.
• W2068368081 cites W1991909462 @default.
• W2068368081 cites W1993166724 @default.
• W2068368081 cites W1996227024 @default.
• W2068368081 cites W1996476613 @default.
• W2068368081 cites W2001382332 @default.
• W2068368081 cites W2002746961 @default.
• W2068368081 cites W2005424117 @default.
• W2068368081 cites W2010618973 @default.
• W2068368081 cites W2011983525 @default.
• W2068368081 cites W2012541271 @default.
• W2068368081 cites W2016452924 @default.
• W2068368081 cites W2019793142 @default.
• W2068368081 cites W2021466920 @default.
• W2068368081 cites W2025679487 @default.
• W2068368081 cites W2026270269 @default.
• W2068368081 cites W2029956564 @default.
• W2068368081 cites W2032152106 @default.
• W2068368081 cites W2032998846 @default.
• W2068368081 cites W2033862669 @default.
• W2068368081 cites W2033984972 @default.
• W2068368081 cites W2034166427 @default.
• W2068368081 cites W2035396914 @default.
• W2068368081 cites W2041270774 @default.
• W2068368081 cites W2042180296 @default.
• W2068368081 cites W2045727840 @default.
• W2068368081 cites W2047048235 @default.
• W2068368081 cites W2048192608 @default.
• W2068368081 cites W2050996284 @default.
• W2068368081 cites W2051010997 @default.
• W2068368081 cites W2055801667 @default.
• W2068368081 cites W2058993916 @default.
• W2068368081 cites W2061815457 @default.
• W2068368081 cites W2064065176 @default.
• W2068368081 cites W2064101480 @default.
• W2068368081 cites W2064889507 @default.
• W2068368081 cites W2065926513 @default.
• W2068368081 cites W2068364000 @default.
• W2068368081 cites W2071540188 @default.
• W2068368081 cites W2073484057 @default.
• W2068368081 cites W2077368275 @default.
• W2068368081 cites W2080725398 @default.
• W2068368081 cites W2082656717 @default.
• W2068368081 cites W2089894391 @default.
• W2068368081 cites W2091091662 @default.
• W2068368081 cites W2094435571 @default.
• W2068368081 cites W2094642525 @default.
• W2068368081 cites W2100594794 @default.
• W2068368081 cites W2101889163 @default.
• W2068368081 cites W2102783377 @default.
• W2068368081 cites W2105057579 @default.
• W2068368081 cites W2108209937 @default.
• W2068368081 cites W2110369097 @default.
• W2068368081 cites W2110444194 @default.
• W2068368081 cites W2113908560 @default.
• W2068368081 cites W2115658797 @default.
• W2068368081 cites W2118418376 @default.
• W2068368081 cites W2120313220 @default.
• W2068368081 cites W2130950384 @default.
• W2068368081 cites W2135502845 @default.
• W2068368081 cites W2146334560 @default.
• W2068368081 cites W2164522850 @default.
• W2068368081 cites W2167543749 @default.
• W2068368081 cites W2168482896 @default.
• W2068368081 cites W2168662633 @default.
• W2068368081 cites W2170111895 @default.
• W2068368081 cites W2341096448 @default.
• W2068368081 cites W2395713166 @default.
• W2068368081 cites W2414652287 @default.
• W2068368081 cites W2418218064 @default.
• W2068368081 cites W2418394729 @default.
• W2068368081 cites W2419477521 @default.
• W2068368081 cites W3140161442 @default.
• W2068368081 doi "https://doi.org/10.1016/j.mehy.2005.07.031" @default.
• W2068368081 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16183208" @default.
• W2068368081 hasPublicationYear "2006" @default.
• W2068368081 type Work @default.

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