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• W2068371335 abstract "We analyzed a chromosomal translocation, t(2;8) (p11;q24), in a Burkitt's lymphoma cell line, KOBK101. The translocation iprocally occurred between a site about 150bp upstream from the J 5 segment in the Ig k -encoding gene on chromosome 2 and the A-rich end of an Alu repetitive element located far downstream from the c- myc gene on chromosome 8. Short segments of both parental chromosomes were deleted at the rearrangement site. A sequence related to the heptamer recognition signal for the V-J recombination of Ig genes and a topoisomerase I-recognition sequence were detected at the breakpoints. The V-J recombination occurred on both chromosome 2 and the translocated chromosome 2p - at the J 3 and J 4 segments, respectively. The J region on the translocated chromosomes was mutated, as compared with that on the untranslocated chromosome, while the Alu element and its upstream sequence were conserved. These results suggest the following aspects to the chromosomal translocation of this cell line. A V-J recombination seems to have occurred at the proximal end of the J 4 segment first, and then the translocation took place m the region between the J 4 and J 5 segments. The translocation may have been mediated by the functions of topoisomerase I and the Alu repetitive sequence located at the breakpoint, although the possibility cannot be ruled out that the recombination machinery for Ig gene rearrangements functioned irregularly." @default.
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• W2068371335 date "1991-01-01" @default.
• W2068371335 modified "2023-09-26" @default.
• W2068371335 title "Genetic recombination in a chromosomal translocation t(2;8) (p11;q24) of a Burkitt's lymphoma cell line, KOBK101" @default.
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• W2068371335 doi "https://doi.org/10.1016/0378-1119(91)90057-i" @default.
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