FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2068380327> ?p ?o ?g. }

• W2068380327 endingPage "320" @default.
• W2068380327 startingPage "311" @default.
• W2068380327 abstract "Noninvasive methods for detecting colorectal tumors have the potential to reduce morbidity and mortality from this disease. The mutations in the adenomatous polyposis coli (APC) gene that initiate colorectal tumors theoretically provide an optimal marker for detecting colorectal tumors. The purpose of our study was to determine the feasibility of detecting APC mutations in fecal DNA with the use of newly developed methods.We purified DNA from routinely collected stool samples and screened for APC mutations with the use of a novel approach called digital protein truncation. Many different mutations could potentially be identified in a sensitive and specific manner with this technique.Stool samples from 28 patients with nonmetastatic colorectal cancers, 18 patients with adenomas that were at least 1 cm in diameter, and 28 control patients without neoplastic disease were studied. APC mutations were identified in 26 of the 46 patients with neoplasia (57 percent; 95 percent confidence interval, 41 to 71 percent) and in none of the 28 control patients (0 percent; 95 percent confidence interval, 0 to 12 percent; P<0.001). In the patients with positive tests, mutant APC genes made up 0.4 to 14.1 percent of all APC genes in the stool.APC mutations can be detected in fecal DNA from patients with relatively early colorectal tumors. This feasibility study suggests a new approach for the early detection of colorectal neoplasms." @default.
• W2068380327 created "2016-06-24" @default.
• W2068380327 creator A5018278944 @default.
• W2068380327 creator A5028026814 @default.
• W2068380327 creator A5033593670 @default.
• W2068380327 creator A5042463747 @default.
• W2068380327 creator A5048211923 @default.
• W2068380327 creator A5051326423 @default.
• W2068380327 creator A5059462255 @default.
• W2068380327 creator A5072858943 @default.
• W2068380327 creator A5078636533 @default.
• W2068380327 creator A5090833674 @default.
• W2068380327 date "2002-01-31" @default.
• W2068380327 modified "2023-10-12" @default.
• W2068380327 title "Detection of<i>APC</i>Mutations in Fecal DNA from Patients with Colorectal Tumors" @default.
• W2068380327 cites W1562197307 @default.
• W2068380327 cites W1982793182 @default.
• W2068380327 cites W1995134833 @default.
• W2068380327 cites W2005250296 @default.
• W2068380327 cites W2009460002 @default.
• W2068380327 cites W2011202553 @default.
• W2068380327 cites W2014495259 @default.
• W2068380327 cites W2015213611 @default.
• W2068380327 cites W2021362203 @default.
• W2068380327 cites W2045207886 @default.
• W2068380327 cites W2046686567 @default.
• W2068380327 cites W2047136948 @default.
• W2068380327 cites W2071964845 @default.
• W2068380327 cites W2072679314 @default.
• W2068380327 cites W2074375044 @default.
• W2068380327 cites W2077348225 @default.
• W2068380327 cites W2082106101 @default.
• W2068380327 cites W2088908240 @default.
• W2068380327 cites W2093052768 @default.
• W2068380327 cites W2093531978 @default.
• W2068380327 cites W2094073090 @default.
• W2068380327 cites W2118835794 @default.
• W2068380327 cites W2121379767 @default.
• W2068380327 cites W2121449717 @default.
• W2068380327 cites W2123244768 @default.
• W2068380327 cites W2134997723 @default.
• W2068380327 cites W2145602937 @default.
• W2068380327 cites W2168231749 @default.
• W2068380327 cites W2268798381 @default.
• W2068380327 cites W2316842579 @default.
• W2068380327 cites W2331004088 @default.
• W2068380327 cites W2333024423 @default.
• W2068380327 cites W4233487535 @default.
• W2068380327 cites W4237610859 @default.
• W2068380327 cites W4249263639 @default.
• W2068380327 doi "https://doi.org/10.1056/nejmoa012294" @default.
• W2068380327 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11821507" @default.
• W2068380327 hasPublicationYear "2002" @default.
• W2068380327 type Work @default.
• W2068380327 sameAs 2068380327 @default.
• W2068380327 citedByCount "320" @default.
• W2068380327 countsByYear W20683803272012 @default.
• W2068380327 countsByYear W20683803272013 @default.
• W2068380327 countsByYear W20683803272014 @default.
• W2068380327 countsByYear W20683803272015 @default.
• W2068380327 countsByYear W20683803272016 @default.
• W2068380327 countsByYear W20683803272017 @default.
• W2068380327 countsByYear W20683803272018 @default.
• W2068380327 countsByYear W20683803272019 @default.
• W2068380327 countsByYear W20683803272020 @default.
• W2068380327 countsByYear W20683803272022 @default.
• W2068380327 countsByYear W20683803272023 @default.
• W2068380327 crossrefType "journal-article" @default.
• W2068380327 hasAuthorship W2068380327A5018278944 @default.
• W2068380327 hasAuthorship W2068380327A5028026814 @default.
• W2068380327 hasAuthorship W2068380327A5033593670 @default.
• W2068380327 hasAuthorship W2068380327A5042463747 @default.
• W2068380327 hasAuthorship W2068380327A5048211923 @default.
• W2068380327 hasAuthorship W2068380327A5051326423 @default.
• W2068380327 hasAuthorship W2068380327A5059462255 @default.
• W2068380327 hasAuthorship W2068380327A5072858943 @default.
• W2068380327 hasAuthorship W2068380327A5078636533 @default.
• W2068380327 hasAuthorship W2068380327A5090833674 @default.
• W2068380327 hasBestOaLocation W20683803271 @default.
• W2068380327 hasConcept C104317684 @default.
• W2068380327 hasConcept C121608353 @default.
• W2068380327 hasConcept C126322002 @default.
• W2068380327 hasConcept C151730666 @default.
• W2068380327 hasConcept C2778237340 @default.
• W2068380327 hasConcept C2781187634 @default.
• W2068380327 hasConcept C44249647 @default.
• W2068380327 hasConcept C48126324 @default.
• W2068380327 hasConcept C49105822 @default.
• W2068380327 hasConcept C526805850 @default.
• W2068380327 hasConcept C54355233 @default.
• W2068380327 hasConcept C61716771 @default.
• W2068380327 hasConcept C71924100 @default.
• W2068380327 hasConcept C86803240 @default.
• W2068380327 hasConcept C90924648 @default.
• W2068380327 hasConceptScore W2068380327C104317684 @default.
• W2068380327 hasConceptScore W2068380327C121608353 @default.
• W2068380327 hasConceptScore W2068380327C126322002 @default.
• W2068380327 hasConceptScore W2068380327C151730666 @default.

• next