Matches in SemOpenAlex for { <https://semopenalex.org/work/W2068384505> ?p ?o ?g. }
- W2068384505 endingPage "719" @default.
- W2068384505 startingPage "708" @default.
- W2068384505 abstract "Abstract A reduction of 70% of the plasma membrane‐associated sialidase Neu3 activity, due to a corresponding reduction of the enzyme expression by transducing cells with a short hairpin RNA encoding a sequence target (complementary messenger of mouse Neu3), caused neurite elongation in Neuro2a murine neuroblastoma cells. The differentiation process was accompanied in parallel by an increase of the acetylcholinesterase activity, a moderate increase of the c‐Src expression and by the presence of the axonal marker tau protein on the neurites. The sphingolipid pattern and turnover in transduced and control cells were characterized by thin layer chromatography, mass spectrometry and metabolic radiolabeling after feeding cells with tritiated sphingosine. Control cells contained about 2 nmol of gangliosides/mg cell protein. GM2 was the main compound, followed by GD1a, GM3 and GM1. In Neu3 silenced cells, the total ganglioside content remained quite similar, but GM2 increased by 54%, GM3 remain constant, and GM1 and GD1a decreased by 66% and 50%, respectively. Within the organic phase sphingolipids, ceramide decreased by 50%, whereas the sphingomyelin content did not change in Neu3 silenced cells." @default.
- W2068384505 created "2016-06-24" @default.
- W2068384505 creator A5001416579 @default.
- W2068384505 creator A5005326174 @default.
- W2068384505 creator A5033267429 @default.
- W2068384505 creator A5035014869 @default.
- W2068384505 creator A5050681885 @default.
- W2068384505 creator A5077676515 @default.
- W2068384505 creator A5079021237 @default.
- W2068384505 creator A5080521278 @default.
- W2068384505 date "2006-10-24" @default.
- W2068384505 modified "2023-10-16" @default.
- W2068384505 title "Induction of axonal differentiation by silencing plasma membrane-associated sialidase Neu3 in neuroblastoma cells" @default.
- W2068384505 cites W1562832796 @default.
- W2068384505 cites W1562899443 @default.
- W2068384505 cites W164434761 @default.
- W2068384505 cites W1660150417 @default.
- W2068384505 cites W170185101 @default.
- W2068384505 cites W170818010 @default.
- W2068384505 cites W1951761438 @default.
- W2068384505 cites W1964464047 @default.
- W2068384505 cites W1966234776 @default.
- W2068384505 cites W1971048984 @default.
- W2068384505 cites W1972149030 @default.
- W2068384505 cites W1975499205 @default.
- W2068384505 cites W1982704287 @default.
- W2068384505 cites W1988193173 @default.
- W2068384505 cites W1989580390 @default.
- W2068384505 cites W1994752272 @default.
- W2068384505 cites W1997916071 @default.
- W2068384505 cites W2000234805 @default.
- W2068384505 cites W2004748537 @default.
- W2068384505 cites W2004999534 @default.
- W2068384505 cites W2009908869 @default.
- W2068384505 cites W2019032890 @default.
- W2068384505 cites W2020040819 @default.
- W2068384505 cites W2037049457 @default.
- W2068384505 cites W2041122748 @default.
- W2068384505 cites W2052369566 @default.
- W2068384505 cites W2072587037 @default.
- W2068384505 cites W2076881925 @default.
- W2068384505 cites W2083243993 @default.
- W2068384505 cites W2091134325 @default.
- W2068384505 cites W2095743880 @default.
- W2068384505 cites W2108352213 @default.
- W2068384505 cites W2119583049 @default.
- W2068384505 cites W2138976254 @default.
- W2068384505 cites W2151260274 @default.
- W2068384505 cites W2162059971 @default.
- W2068384505 cites W2164607025 @default.
- W2068384505 cites W2166371391 @default.
- W2068384505 cites W2302680933 @default.
- W2068384505 cites W2326448744 @default.
- W2068384505 cites W39003193 @default.
- W2068384505 cites W4249223443 @default.
- W2068384505 cites W2092292187 @default.
- W2068384505 doi "https://doi.org/10.1111/j.1471-4159.2006.04279.x" @default.
- W2068384505 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17176265" @default.
- W2068384505 hasPublicationYear "2006" @default.
- W2068384505 type Work @default.
- W2068384505 sameAs 2068384505 @default.
- W2068384505 citedByCount "36" @default.
- W2068384505 countsByYear W20683845052012 @default.
- W2068384505 countsByYear W20683845052013 @default.
- W2068384505 countsByYear W20683845052014 @default.
- W2068384505 countsByYear W20683845052017 @default.
- W2068384505 countsByYear W20683845052018 @default.
- W2068384505 countsByYear W20683845052019 @default.
- W2068384505 countsByYear W20683845052020 @default.
- W2068384505 countsByYear W20683845052021 @default.
- W2068384505 countsByYear W20683845052022 @default.
- W2068384505 crossrefType "journal-article" @default.
- W2068384505 hasAuthorship W2068384505A5001416579 @default.
- W2068384505 hasAuthorship W2068384505A5005326174 @default.
- W2068384505 hasAuthorship W2068384505A5033267429 @default.
- W2068384505 hasAuthorship W2068384505A5035014869 @default.
- W2068384505 hasAuthorship W2068384505A5050681885 @default.
- W2068384505 hasAuthorship W2068384505A5077676515 @default.
- W2068384505 hasAuthorship W2068384505A5079021237 @default.
- W2068384505 hasAuthorship W2068384505A5080521278 @default.
- W2068384505 hasBestOaLocation W20683845051 @default.
- W2068384505 hasConcept C104317684 @default.
- W2068384505 hasConcept C113246987 @default.
- W2068384505 hasConcept C119056186 @default.
- W2068384505 hasConcept C148738053 @default.
- W2068384505 hasConcept C153911025 @default.
- W2068384505 hasConcept C170493617 @default.
- W2068384505 hasConcept C185592680 @default.
- W2068384505 hasConcept C190283241 @default.
- W2068384505 hasConcept C202751555 @default.
- W2068384505 hasConcept C2777331542 @default.
- W2068384505 hasConcept C2777851122 @default.
- W2068384505 hasConcept C2778703144 @default.
- W2068384505 hasConcept C41625074 @default.
- W2068384505 hasConcept C55493867 @default.
- W2068384505 hasConcept C61322309 @default.
- W2068384505 hasConcept C61705674 @default.
- W2068384505 hasConcept C86803240 @default.