FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2068385744> ?p ?o ?g. }

• W2068385744 endingPage "1392" @default.
• W2068385744 startingPage "1383" @default.
• W2068385744 abstract "Background: Reconstruction of large craniofacial bone defects is a challenge using bone transplants or alloplastic materials. The use of bone morphogenetic protein (BMP)-2 together with a suitable carrier is an attractive option that may facilitate new bone formation. The authors have developed a hydrogel that is formed in situ by the cross-linking of multifunctional hyaluronic acid and polyvinyl alcohol derivatives mixed with hydroxyapatite nanoparticles, in the presence of BMP-2. The aim of this study was to evaluate the suitability of the hydrogel as a carrier for BMP-2 in repairing critical size cranial defects in a minipig model. Methods: Cranial defects (2 × 4 cm) were created in 14 minipigs. The experimental groups were as follows: group 1, craniotomy and application of 5 ml of hydrogel with 1.25 mg of BMP-2 (n = 6); group 2, craniotomy and application of 5 ml of hydrogel without BMP-2 (n = 6); and group 3, craniotomy with no further treatment (n = 2). Results: After 3 months, computed tomographic and histologic examinations were performed. There was spontaneous ossification in the untreated group, but the healing was incomplete. The hydrogel alone demonstrated no further effects. The addition of 1.25 mg of BMP-2 to the hydrogel induced a greater than 100 percent increase in bone volume (p = 0.003) and complete healing of the defects. Histologic examination revealed compact lamellar bone in the BMP group without intertrabecular fibrous tissue, as was seen in the other groups. The hydrogel was resorbed completely within 3 months and, importantly, caused no inflammatory reaction. Conclusion: The injectable hydrogel may be favorable as a BMP-2 carrier for bone reconstruction." @default.
• W2068385744 created "2016-06-24" @default.
• W2068385744 creator A5001270794 @default.
• W2068385744 creator A5016989653 @default.
• W2068385744 creator A5019030826 @default.
• W2068385744 creator A5031333149 @default.
• W2068385744 creator A5038023520 @default.
• W2068385744 creator A5043445920 @default.
• W2068385744 creator A5046589727 @default.
• W2068385744 creator A5053292861 @default.
• W2068385744 creator A5087861993 @default.
• W2068385744 date "2010-05-01" @default.
• W2068385744 modified "2023-10-07" @default.
• W2068385744 title "Bone Morphogenetic Protein-2 Delivered by Hyaluronan-Based Hydrogel Induces Massive Bone Formation and Healing of Cranial Defects in Minipigs" @default.
• W2068385744 cites W1548923710 @default.
• W2068385744 cites W1970525947 @default.
• W2068385744 cites W1975463875 @default.
• W2068385744 cites W1981069514 @default.
• W2068385744 cites W1985366897 @default.
• W2068385744 cites W1995713263 @default.
• W2068385744 cites W1999277351 @default.
• W2068385744 cites W2008943389 @default.
• W2068385744 cites W2032740145 @default.
• W2068385744 cites W2040190462 @default.
• W2068385744 cites W2047297548 @default.
• W2068385744 cites W2058143379 @default.
• W2068385744 cites W2063142742 @default.
• W2068385744 cites W2066966685 @default.
• W2068385744 cites W2078432559 @default.
• W2068385744 cites W2079737979 @default.
• W2068385744 cites W2084610464 @default.
• W2068385744 cites W2086361550 @default.
• W2068385744 cites W2087435536 @default.
• W2068385744 cites W2089508440 @default.
• W2068385744 cites W2094111430 @default.
• W2068385744 cites W2108575425 @default.
• W2068385744 cites W2121047776 @default.
• W2068385744 cites W2130635700 @default.
• W2068385744 cites W2139586508 @default.
• W2068385744 cites W2142720627 @default.
• W2068385744 cites W2144623968 @default.
• W2068385744 cites W4299796953 @default.
• W2068385744 cites W60518722 @default.
• W2068385744 doi "https://doi.org/10.1097/prs.0b013e3181d629dc" @default.
• W2068385744 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20440158" @default.
• W2068385744 hasPublicationYear "2010" @default.
• W2068385744 type Work @default.
• W2068385744 sameAs 2068385744 @default.
• W2068385744 citedByCount "64" @default.
• W2068385744 countsByYear W20683857442012 @default.
• W2068385744 countsByYear W20683857442013 @default.
• W2068385744 countsByYear W20683857442014 @default.
• W2068385744 countsByYear W20683857442015 @default.
• W2068385744 countsByYear W20683857442016 @default.
• W2068385744 countsByYear W20683857442017 @default.
• W2068385744 countsByYear W20683857442018 @default.
• W2068385744 countsByYear W20683857442019 @default.
• W2068385744 countsByYear W20683857442020 @default.
• W2068385744 countsByYear W20683857442021 @default.
• W2068385744 countsByYear W20683857442022 @default.
• W2068385744 crossrefType "journal-article" @default.
• W2068385744 hasAuthorship W2068385744A5001270794 @default.
• W2068385744 hasAuthorship W2068385744A5016989653 @default.
• W2068385744 hasAuthorship W2068385744A5019030826 @default.
• W2068385744 hasAuthorship W2068385744A5031333149 @default.
• W2068385744 hasAuthorship W2068385744A5038023520 @default.
• W2068385744 hasAuthorship W2068385744A5043445920 @default.
• W2068385744 hasAuthorship W2068385744A5046589727 @default.
• W2068385744 hasAuthorship W2068385744A5053292861 @default.
• W2068385744 hasAuthorship W2068385744A5087861993 @default.
• W2068385744 hasConcept C104317684 @default.
• W2068385744 hasConcept C105702510 @default.
• W2068385744 hasConcept C118552586 @default.
• W2068385744 hasConcept C136229726 @default.
• W2068385744 hasConcept C141071460 @default.
• W2068385744 hasConcept C185592680 @default.
• W2068385744 hasConcept C199343813 @default.
• W2068385744 hasConcept C202751555 @default.
• W2068385744 hasConcept C2777529286 @default.
• W2068385744 hasConcept C2778842504 @default.
• W2068385744 hasConcept C2778871575 @default.
• W2068385744 hasConcept C2779300802 @default.
• W2068385744 hasConcept C2781245598 @default.
• W2068385744 hasConcept C2911217788 @default.
• W2068385744 hasConcept C30352789 @default.
• W2068385744 hasConcept C31507581 @default.
• W2068385744 hasConcept C55493867 @default.
• W2068385744 hasConcept C71924100 @default.
• W2068385744 hasConcept C8337478 @default.
• W2068385744 hasConceptScore W2068385744C104317684 @default.
• W2068385744 hasConceptScore W2068385744C105702510 @default.
• W2068385744 hasConceptScore W2068385744C118552586 @default.
• W2068385744 hasConceptScore W2068385744C136229726 @default.
• W2068385744 hasConceptScore W2068385744C141071460 @default.
• W2068385744 hasConceptScore W2068385744C185592680 @default.
• W2068385744 hasConceptScore W2068385744C199343813 @default.
• W2068385744 hasConceptScore W2068385744C202751555 @default.
• W2068385744 hasConceptScore W2068385744C2777529286 @default.

• next