Matches in SemOpenAlex for { <https://semopenalex.org/work/W2068389268> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W2068389268 endingPage "83" @default.
- W2068389268 startingPage "74" @default.
- W2068389268 abstract "A method utilizing reverse-phase liquid chromatography/electrochemistry (LCEC) was developed for the simultaneous determination of aniline and its hydroxylated derivatives, p-aminophenol, o-aminophenol, m-aminophenol, and N-phenylhydroxylamine. To achieve separation of these compounds, a mobile phase of 3.0% dimethylformamide and 97.0% 0.05 m piperazine acetate, pH 5.4, containing 0.05 m KNO3 was developed. A procedure is also presented for the determination of p-nitrophenol, nitrobenzene, and nitrosobenzene, possible aniline metabolites in higher N-oxidation states, using reductive amperometric detection. The hydroxylated compounds, including the hydroxylamine, and nitrosobenzene are easily detected as metabolites of aniline in mouse liver slice or microsomal preparations. No prior extraction, preconcentration, or derivatization steps are needed for the determinations, which can be accomplished by a direct injection of the incubation mixture. The Km value for the hepatic aniline 4-hydroxylase activity in male Cox-Swiss mice microsomal preparations has been determined to be 0.52 mm; the Vmax value is 2.90 ± 0.64 nmol min−1 mg microsomal protein−1. Detection limits for all compounds of interest are in the picomole range." @default.
- W2068389268 created "2016-06-24" @default.
- W2068389268 creator A5010849548 @default.
- W2068389268 creator A5013571530 @default.
- W2068389268 date "1984-07-01" @default.
- W2068389268 modified "2023-09-27" @default.
- W2068389268 title "Determination of aniline and metabolites produced in vitro by liquid chromatography/electrochemistry" @default.
- W2068389268 cites W1775749144 @default.
- W2068389268 cites W1968994009 @default.
- W2068389268 cites W1971296064 @default.
- W2068389268 cites W1995858801 @default.
- W2068389268 cites W1998181866 @default.
- W2068389268 cites W2019460694 @default.
- W2068389268 cites W2021390693 @default.
- W2068389268 cites W2026802456 @default.
- W2068389268 cites W2032447111 @default.
- W2068389268 cites W2037179886 @default.
- W2068389268 cites W2042711906 @default.
- W2068389268 cites W2050957682 @default.
- W2068389268 cites W2058213918 @default.
- W2068389268 cites W2065092383 @default.
- W2068389268 cites W2068404621 @default.
- W2068389268 cites W2076320450 @default.
- W2068389268 cites W2086144059 @default.
- W2068389268 cites W2097824816 @default.
- W2068389268 cites W2143542298 @default.
- W2068389268 cites W2152106696 @default.
- W2068389268 cites W85293829 @default.
- W2068389268 doi "https://doi.org/10.1016/0003-2697(84)90135-0" @default.
- W2068389268 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6486418" @default.
- W2068389268 hasPublicationYear "1984" @default.
- W2068389268 type Work @default.
- W2068389268 sameAs 2068389268 @default.
- W2068389268 citedByCount "14" @default.
- W2068389268 countsByYear W20683892682018 @default.
- W2068389268 countsByYear W20683892682021 @default.
- W2068389268 crossrefType "journal-article" @default.
- W2068389268 hasAuthorship W2068389268A5010849548 @default.
- W2068389268 hasAuthorship W2068389268A5013571530 @default.
- W2068389268 hasConcept C119128265 @default.
- W2068389268 hasConcept C139369640 @default.
- W2068389268 hasConcept C13965031 @default.
- W2068389268 hasConcept C147789679 @default.
- W2068389268 hasConcept C161790260 @default.
- W2068389268 hasConcept C17525397 @default.
- W2068389268 hasConcept C178790620 @default.
- W2068389268 hasConcept C179998833 @default.
- W2068389268 hasConcept C181199279 @default.
- W2068389268 hasConcept C185592680 @default.
- W2068389268 hasConcept C2775999725 @default.
- W2068389268 hasConcept C2776923573 @default.
- W2068389268 hasConcept C2778478478 @default.
- W2068389268 hasConcept C2779244968 @default.
- W2068389268 hasConcept C2780809723 @default.
- W2068389268 hasConcept C2910042226 @default.
- W2068389268 hasConcept C43617362 @default.
- W2068389268 hasConcept C52859227 @default.
- W2068389268 hasConcept C87644729 @default.
- W2068389268 hasConceptScore W2068389268C119128265 @default.
- W2068389268 hasConceptScore W2068389268C139369640 @default.
- W2068389268 hasConceptScore W2068389268C13965031 @default.
- W2068389268 hasConceptScore W2068389268C147789679 @default.
- W2068389268 hasConceptScore W2068389268C161790260 @default.
- W2068389268 hasConceptScore W2068389268C17525397 @default.
- W2068389268 hasConceptScore W2068389268C178790620 @default.
- W2068389268 hasConceptScore W2068389268C179998833 @default.
- W2068389268 hasConceptScore W2068389268C181199279 @default.
- W2068389268 hasConceptScore W2068389268C185592680 @default.
- W2068389268 hasConceptScore W2068389268C2775999725 @default.
- W2068389268 hasConceptScore W2068389268C2776923573 @default.
- W2068389268 hasConceptScore W2068389268C2778478478 @default.
- W2068389268 hasConceptScore W2068389268C2779244968 @default.
- W2068389268 hasConceptScore W2068389268C2780809723 @default.
- W2068389268 hasConceptScore W2068389268C2910042226 @default.
- W2068389268 hasConceptScore W2068389268C43617362 @default.
- W2068389268 hasConceptScore W2068389268C52859227 @default.
- W2068389268 hasConceptScore W2068389268C87644729 @default.
- W2068389268 hasIssue "1" @default.
- W2068389268 hasLocation W20683892681 @default.
- W2068389268 hasLocation W20683892682 @default.
- W2068389268 hasOpenAccess W2068389268 @default.
- W2068389268 hasPrimaryLocation W20683892681 @default.
- W2068389268 hasRelatedWork W1764881939 @default.
- W2068389268 hasRelatedWork W1964259887 @default.
- W2068389268 hasRelatedWork W1987023309 @default.
- W2068389268 hasRelatedWork W2010743637 @default.
- W2068389268 hasRelatedWork W2044206509 @default.
- W2068389268 hasRelatedWork W2045608543 @default.
- W2068389268 hasRelatedWork W2062402189 @default.
- W2068389268 hasRelatedWork W2068389268 @default.
- W2068389268 hasRelatedWork W2075944128 @default.
- W2068389268 hasRelatedWork W2096641431 @default.
- W2068389268 hasVolume "140" @default.
- W2068389268 isParatext "false" @default.
- W2068389268 isRetracted "false" @default.
- W2068389268 magId "2068389268" @default.
- W2068389268 workType "article" @default.