Matches in SemOpenAlex for { <https://semopenalex.org/work/W2068399094> ?p ?o ?g. }
Showing items 1 to 72 of
72
with 100 items per page.
- W2068399094 abstract "Maintaining the viability of an extended skin flap remains one of the continuing challenges in reconstructive surgery. As flaps lengthen, viability becomes more unpredictable and necrosis of distal segments can occur. The specific mechanisms involved in determining flap survival remain unclear, but vasoconstriction within the flap microcirculation appears to play a significant role in regulating flap viability. Vasodilators have been used, with limited success, in an attempt to improve survival of ischemic skin flaps in rats. One such agent, nifedipine, a calcium channel blocker, demonstrated conflicting results when used to improve rat skin flap survival, despite its potent vasodilating properties. A standard rat flap model was used to help clarify the potential of nifedipine to salvage ischemic skin flaps. Alterations in flap perfusion were assessed using a laser Doppler flowmeter and dermofluorometry in an attempt to characterize nifedipine's mechanism of action on flap preservation. Increased flap survival was demonstrated in treatment animals when compared to controls. Despite significant improvement in flap viability, perfusion measurements failed to confirm increased flow within the flap microcirculation. Although the mechanisms of action remain speculative, nifedipine may have important therapeutic potential in improving skin flap survival in a clinical setting." @default.
- W2068399094 created "2016-06-24" @default.
- W2068399094 creator A5010132004 @default.
- W2068399094 creator A5042059019 @default.
- W2068399094 creator A5070533862 @default.
- W2068399094 creator A5070819873 @default.
- W2068399094 date "1994-03-01" @default.
- W2068399094 modified "2023-09-30" @default.
- W2068399094 title "The Effect of Nifedipine on Skin Flap Survival in Rats" @default.
- W2068399094 doi "https://doi.org/10.1288/00005537-199403000-00002" @default.
- W2068399094 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8127178" @default.
- W2068399094 hasPublicationYear "1994" @default.
- W2068399094 type Work @default.
- W2068399094 sameAs 2068399094 @default.
- W2068399094 citedByCount "4" @default.
- W2068399094 countsByYear W20683990942017 @default.
- W2068399094 countsByYear W20683990942018 @default.
- W2068399094 crossrefType "journal-article" @default.
- W2068399094 hasAuthorship W2068399094A5010132004 @default.
- W2068399094 hasAuthorship W2068399094A5042059019 @default.
- W2068399094 hasAuthorship W2068399094A5070533862 @default.
- W2068399094 hasAuthorship W2068399094A5070819873 @default.
- W2068399094 hasConcept C120770815 @default.
- W2068399094 hasConcept C126322002 @default.
- W2068399094 hasConcept C12722491 @default.
- W2068399094 hasConcept C141071460 @default.
- W2068399094 hasConcept C146957229 @default.
- W2068399094 hasConcept C158846371 @default.
- W2068399094 hasConcept C164705383 @default.
- W2068399094 hasConcept C2779066535 @default.
- W2068399094 hasConcept C2779961880 @default.
- W2068399094 hasConcept C2780356492 @default.
- W2068399094 hasConcept C2991913917 @default.
- W2068399094 hasConcept C42219234 @default.
- W2068399094 hasConcept C519063684 @default.
- W2068399094 hasConcept C52305850 @default.
- W2068399094 hasConcept C541997718 @default.
- W2068399094 hasConcept C71924100 @default.
- W2068399094 hasConceptScore W2068399094C120770815 @default.
- W2068399094 hasConceptScore W2068399094C126322002 @default.
- W2068399094 hasConceptScore W2068399094C12722491 @default.
- W2068399094 hasConceptScore W2068399094C141071460 @default.
- W2068399094 hasConceptScore W2068399094C146957229 @default.
- W2068399094 hasConceptScore W2068399094C158846371 @default.
- W2068399094 hasConceptScore W2068399094C164705383 @default.
- W2068399094 hasConceptScore W2068399094C2779066535 @default.
- W2068399094 hasConceptScore W2068399094C2779961880 @default.
- W2068399094 hasConceptScore W2068399094C2780356492 @default.
- W2068399094 hasConceptScore W2068399094C2991913917 @default.
- W2068399094 hasConceptScore W2068399094C42219234 @default.
- W2068399094 hasConceptScore W2068399094C519063684 @default.
- W2068399094 hasConceptScore W2068399094C52305850 @default.
- W2068399094 hasConceptScore W2068399094C541997718 @default.
- W2068399094 hasConceptScore W2068399094C71924100 @default.
- W2068399094 hasLocation W20683990941 @default.
- W2068399094 hasLocation W20683990942 @default.
- W2068399094 hasOpenAccess W2068399094 @default.
- W2068399094 hasPrimaryLocation W20683990941 @default.
- W2068399094 hasRelatedWork W2024509071 @default.
- W2068399094 hasRelatedWork W2025411917 @default.
- W2068399094 hasRelatedWork W2049579935 @default.
- W2068399094 hasRelatedWork W2068399094 @default.
- W2068399094 hasRelatedWork W2131906142 @default.
- W2068399094 hasRelatedWork W2395797005 @default.
- W2068399094 hasRelatedWork W2412344370 @default.
- W2068399094 hasRelatedWork W600848024 @default.
- W2068399094 hasRelatedWork W2161442242 @default.
- W2068399094 hasRelatedWork W3023252113 @default.
- W2068399094 isParatext "false" @default.
- W2068399094 isRetracted "false" @default.
- W2068399094 magId "2068399094" @default.
- W2068399094 workType "article" @default.