FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2068399488> ?p ?o ?g. }

• W2068399488 endingPage "1037" @default.
• W2068399488 startingPage "1031" @default.
• W2068399488 abstract "We tested the hypothesis that cyclic alterations in coronary artery blood flow that occurred after coronary angioplasty could be attenuated or abolished by a monoclonal antibody to the platelet surface membrane GP IIb/IIIa receptor.Coronary artery cyclic flow variations may occur after coronary angioplasty in experimental animal models and humans. In animal models of coronary thrombosis, cyclic alterations in flow often have preceded thrombotic occlusion or reocclusion. Several agents that inhibit platelet function have been shown to attenuate or eliminate cyclic flow variations in these models.We monitored coronary artery flow in 27 patients for 30 min after coronary angioplasty, using 0.018-in. (0.046 cm) coronary guide wires with pulsed wave Doppler ultrasound transducers on the distal tips. Clinical data were collected and quantitative analyses performed on coronary arteriograms made before and after the angioplasty procedures. We compared findings in patients with and without cyclic flow variations detected.There were 20 men and 7 women. Mean age was 58 years, and 63% had unstable angina. They received standard doses of nitrates, aspirin, heparin, calcium channel antagonists and other medications clinically indicated. Nevertheless, we detected cyclic flow variations in five patients (19%). Four of these patients had stable flow restored with intravenous injection of 0.25 mg/kg normal body weight of monoclonal antibody c7E3 Fab to the platelet GP IIb/IIIa receptor. In one patient, stable flow was restored by repeat dilation when an immediate angiogram revealed renarrowing. Patients developing cyclic alterations in flow had longer lesions (18.7 +/- 7.5 mm vs. 13.1 +/- 5.7 mm, p < 0.05) that had responded less well to angioplasty (stenosis postangioplasty 47 +/- 13% vs. 33 +/- 15%, p < 0.05).Cyclic alterations in coronary artery blood flow may occur in some patients after coronary angioplasty, despite the use of standard antiplatelet, antithrombotic and antivasospastic medications. We found that they could be eliminated by this monoclonal antibody that blocks the final common event of platelet aggregation." @default.
• W2068399488 created "2016-06-24" @default.
• W2068399488 creator A5000351033 @default.
• W2068399488 creator A5039372316 @default.
• W2068399488 creator A5040953863 @default.
• W2068399488 creator A5045515686 @default.
• W2068399488 creator A5056045911 @default.
• W2068399488 creator A5086256081 @default.
• W2068399488 creator A5087655292 @default.
• W2068399488 date "1994-04-01" @default.
• W2068399488 modified "2023-09-26" @default.
• W2068399488 title "Cyclic Flow variations after coronary angioplasty in humans: Clinical and angiographic characteristics and elimination with 7E3 monoclonal antiplatelet antibody" @default.
• W2068399488 cites W1963594660 @default.
• W2068399488 cites W1976686139 @default.
• W2068399488 cites W1984061640 @default.
• W2068399488 cites W1985452790 @default.
• W2068399488 cites W1986845493 @default.
• W2068399488 cites W1988504835 @default.
• W2068399488 cites W1991193692 @default.
• W2068399488 cites W2002644574 @default.
• W2068399488 cites W2007191559 @default.
• W2068399488 cites W2012101236 @default.
• W2068399488 cites W2013117847 @default.
• W2068399488 cites W2015197224 @default.
• W2068399488 cites W2016057814 @default.
• W2068399488 cites W2017212995 @default.
• W2068399488 cites W2024960804 @default.
• W2068399488 cites W2025645539 @default.
• W2068399488 cites W2027451228 @default.
• W2068399488 cites W2028669259 @default.
• W2068399488 cites W2029764519 @default.
• W2068399488 cites W2032210985 @default.
• W2068399488 cites W2035279091 @default.
• W2068399488 cites W2044469215 @default.
• W2068399488 cites W2046902524 @default.
• W2068399488 cites W2049527207 @default.
• W2068399488 cites W2055435744 @default.
• W2068399488 cites W2063477544 @default.
• W2068399488 cites W2066383182 @default.
• W2068399488 cites W2076991332 @default.
• W2068399488 cites W2078824617 @default.
• W2068399488 cites W2081166308 @default.
• W2068399488 cites W2089406251 @default.
• W2068399488 cites W2096917705 @default.
• W2068399488 cites W2117030548 @default.
• W2068399488 cites W2130729751 @default.
• W2068399488 cites W2145318640 @default.
• W2068399488 cites W2164287865 @default.
• W2068399488 cites W2293220210 @default.
• W2068399488 cites W2322445769 @default.
• W2068399488 cites W2330349737 @default.
• W2068399488 cites W2465519329 @default.
• W2068399488 doi "https://doi.org/10.1016/0735-1097(94)90586-x" @default.
• W2068399488 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8144764" @default.
• W2068399488 hasPublicationYear "1994" @default.
• W2068399488 type Work @default.
• W2068399488 sameAs 2068399488 @default.
• W2068399488 citedByCount "73" @default.
• W2068399488 countsByYear W20683994882013 @default.
• W2068399488 crossrefType "journal-article" @default.
• W2068399488 hasAuthorship W2068399488A5000351033 @default.
• W2068399488 hasAuthorship W2068399488A5039372316 @default.
• W2068399488 hasAuthorship W2068399488A5040953863 @default.
• W2068399488 hasAuthorship W2068399488A5045515686 @default.
• W2068399488 hasAuthorship W2068399488A5056045911 @default.
• W2068399488 hasAuthorship W2068399488A5086256081 @default.
• W2068399488 hasAuthorship W2068399488A5087655292 @default.
• W2068399488 hasBestOaLocation W20683994881 @default.
• W2068399488 hasConcept C126322002 @default.
• W2068399488 hasConcept C158846371 @default.
• W2068399488 hasConcept C164705383 @default.
• W2068399488 hasConcept C2776820930 @default.
• W2068399488 hasConcept C2777785093 @default.
• W2068399488 hasConcept C2778425758 @default.
• W2068399488 hasConcept C2778707443 @default.
• W2068399488 hasConcept C2780326628 @default.
• W2068399488 hasConcept C2780868729 @default.
• W2068399488 hasConcept C500558357 @default.
• W2068399488 hasConcept C71924100 @default.
• W2068399488 hasConcept C89560881 @default.
• W2068399488 hasConceptScore W2068399488C126322002 @default.
• W2068399488 hasConceptScore W2068399488C158846371 @default.
• W2068399488 hasConceptScore W2068399488C164705383 @default.
• W2068399488 hasConceptScore W2068399488C2776820930 @default.
• W2068399488 hasConceptScore W2068399488C2777785093 @default.
• W2068399488 hasConceptScore W2068399488C2778425758 @default.
• W2068399488 hasConceptScore W2068399488C2778707443 @default.
• W2068399488 hasConceptScore W2068399488C2780326628 @default.
• W2068399488 hasConceptScore W2068399488C2780868729 @default.
• W2068399488 hasConceptScore W2068399488C500558357 @default.
• W2068399488 hasConceptScore W2068399488C71924100 @default.
• W2068399488 hasConceptScore W2068399488C89560881 @default.
• W2068399488 hasIssue "5" @default.
• W2068399488 hasLocation W20683994881 @default.
• W2068399488 hasLocation W20683994882 @default.
• W2068399488 hasOpenAccess W2068399488 @default.
• W2068399488 hasPrimaryLocation W20683994881 @default.
• W2068399488 hasRelatedWork W1991498847 @default.

• next