FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2068400908> ?p ?o ?g. }

• W2068400908 endingPage "9" @default.
• W2068400908 startingPage "1" @default.
• W2068400908 abstract "Nonsense-mediated decay is a key RNA surveillance mechanism responsible for the rapid degradation of mRNAs containing premature termination codons and hence prevents the synthesis of truncated proteins. More recently, it has been shown that nonsense-mediated decay also has broader significance in controlling the expression of a significant proportion of the transcriptome. The importance of this mechanism to the mammalian cell is demonstrated by the observation that its inhibition causes growth arrest. The noncoding RNA growth arrest specific transcript 5 (GAS5) has recently been shown to play a key role in growth arrest induced by several mechanisms, including serum withdrawal and treatment with the mTOR inhibitor rapamycin. Here we show that inhibition of nonsense-mediated decay in several human lymphocyte cell lines causes growth arrest, and siRNA-mediated downregulation of GAS5 in these cells significantly alleviates the inhibitory effects observed. These observations hold true for inhibition of nonsense-mediated decay both through RNA interference and through pharmacological inhibition by aminoglycoside antibiotics gentamycin and G418. These studies have important implications for ototoxicity and nephrotoxicity caused by gentamycin and for the proposed use of NMD inhibition in treating genetic disease. This report further demonstrates the critical role played by GAS5 in the growth arrest of mammalian cells." @default.
• W2068400908 created "2016-06-24" @default.
• W2068400908 creator A5009145170 @default.
• W2068400908 creator A5090954645 @default.
• W2068400908 date "2013-01-01" @default.
• W2068400908 modified "2023-09-23" @default.
• W2068400908 title "Growth Arrest on Inhibition of Nonsense-Mediated Decay Is Mediated by Noncoding RNA GAS5" @default.
• W2068400908 cites W1501966284 @default.
• W2068400908 cites W1921593493 @default.
• W2068400908 cites W192643021 @default.
• W2068400908 cites W1932653806 @default.
• W2068400908 cites W1968403680 @default.
• W2068400908 cites W1973457997 @default.
• W2068400908 cites W1978068869 @default.
• W2068400908 cites W1990570801 @default.
• W2068400908 cites W1996157974 @default.
• W2068400908 cites W2009757848 @default.
• W2068400908 cites W2010160850 @default.
• W2068400908 cites W2016954412 @default.
• W2068400908 cites W2021518210 @default.
• W2068400908 cites W2027010998 @default.
• W2068400908 cites W2030302003 @default.
• W2068400908 cites W2031478669 @default.
• W2068400908 cites W2043841998 @default.
• W2068400908 cites W2044987787 @default.
• W2068400908 cites W2048515321 @default.
• W2068400908 cites W2050802751 @default.
• W2068400908 cites W2051554148 @default.
• W2068400908 cites W2070443885 @default.
• W2068400908 cites W2071382839 @default.
• W2068400908 cites W2081339873 @default.
• W2068400908 cites W2084212780 @default.
• W2068400908 cites W2095321031 @default.
• W2068400908 cites W2114036672 @default.
• W2068400908 cites W2114635068 @default.
• W2068400908 cites W2123635966 @default.
• W2068400908 cites W2123716946 @default.
• W2068400908 cites W2136032187 @default.
• W2068400908 cites W2136942244 @default.
• W2068400908 cites W2139548637 @default.
• W2068400908 cites W2149973389 @default.
• W2068400908 cites W2154063562 @default.
• W2068400908 cites W2158235544 @default.
• W2068400908 cites W2158816387 @default.
• W2068400908 cites W2169037117 @default.
• W2068400908 cites W2472122515 @default.
• W2068400908 cites W4251872162 @default.
• W2068400908 doi "https://doi.org/10.1155/2013/358015" @default.
• W2068400908 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3844204" @default.
• W2068400908 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24319682" @default.
• W2068400908 hasPublicationYear "2013" @default.
• W2068400908 type Work @default.
• W2068400908 sameAs 2068400908 @default.
• W2068400908 citedByCount "42" @default.
• W2068400908 countsByYear W20684009082014 @default.
• W2068400908 countsByYear W20684009082015 @default.
• W2068400908 countsByYear W20684009082016 @default.
• W2068400908 countsByYear W20684009082017 @default.
• W2068400908 countsByYear W20684009082018 @default.
• W2068400908 countsByYear W20684009082019 @default.
• W2068400908 countsByYear W20684009082020 @default.
• W2068400908 countsByYear W20684009082021 @default.
• W2068400908 countsByYear W20684009082022 @default.
• W2068400908 countsByYear W20684009082023 @default.
• W2068400908 crossrefType "journal-article" @default.
• W2068400908 hasAuthorship W2068400908A5009145170 @default.
• W2068400908 hasAuthorship W2068400908A5090954645 @default.
• W2068400908 hasBestOaLocation W20684009081 @default.
• W2068400908 hasConcept C104317684 @default.
• W2068400908 hasConcept C127561419 @default.
• W2068400908 hasConcept C22615655 @default.
• W2068400908 hasConcept C2776941990 @default.
• W2068400908 hasConcept C2779707156 @default.
• W2068400908 hasConcept C501734568 @default.
• W2068400908 hasConcept C54355233 @default.
• W2068400908 hasConcept C62112901 @default.
• W2068400908 hasConcept C62203573 @default.
• W2068400908 hasConcept C62478195 @default.
• W2068400908 hasConcept C67705224 @default.
• W2068400908 hasConcept C75563809 @default.
• W2068400908 hasConcept C86554907 @default.
• W2068400908 hasConcept C86803240 @default.
• W2068400908 hasConcept C95444343 @default.
• W2068400908 hasConcept C96777560 @default.
• W2068400908 hasConceptScore W2068400908C104317684 @default.
• W2068400908 hasConceptScore W2068400908C127561419 @default.
• W2068400908 hasConceptScore W2068400908C22615655 @default.
• W2068400908 hasConceptScore W2068400908C2776941990 @default.
• W2068400908 hasConceptScore W2068400908C2779707156 @default.
• W2068400908 hasConceptScore W2068400908C501734568 @default.
• W2068400908 hasConceptScore W2068400908C54355233 @default.
• W2068400908 hasConceptScore W2068400908C62112901 @default.
• W2068400908 hasConceptScore W2068400908C62203573 @default.
• W2068400908 hasConceptScore W2068400908C62478195 @default.
• W2068400908 hasConceptScore W2068400908C67705224 @default.
• W2068400908 hasConceptScore W2068400908C75563809 @default.
• W2068400908 hasConceptScore W2068400908C86554907 @default.
• W2068400908 hasConceptScore W2068400908C86803240 @default.

• next