FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2068404502> ?p ?o ?g. }

• W2068404502 endingPage "1581" @default.
• W2068404502 startingPage "1572" @default.
• W2068404502 abstract "A series of 3-substituted (5c-5f, 6c-6f) and 4-substituted (10a-10g) oxoisoaporphine derivatives were synthesized. It was found that all these synthetic compounds had IC50 values at micro or nano molar range for cholinesterase inhibition, and most of them could inhibit amyloid β (Aβ) self-induced aggregation with inhibition ratio from 31.8% to 57.6%. The structure-activity relationship studies revealed that the derivatives with higher selectivity on AChE also showed better inhibition on Aβ self-induced aggregation. The results from cell toxicity study indicated that most quaternary methiodide salts had higher IC50 values than the corresponding non-quaternary compounds. This study provided potentially important information for further development of oxoisoaporphine derivatives as lead compounds for the treatment of Alzheimer's disease." @default.
• W2068404502 created "2016-06-24" @default.
• W2068404502 creator A5004244292 @default.
• W2068404502 creator A5009900444 @default.
• W2068404502 creator A5017231732 @default.
• W2068404502 creator A5017464022 @default.
• W2068404502 creator A5023832499 @default.
• W2068404502 creator A5032782538 @default.
• W2068404502 creator A5042772858 @default.
• W2068404502 creator A5047620512 @default.
• W2068404502 creator A5059184457 @default.
• W2068404502 creator A5080622742 @default.
• W2068404502 creator A5082251778 @default.
• W2068404502 date "2011-05-01" @default.
• W2068404502 modified "2023-10-16" @default.
• W2068404502 title "Syntheses and characterization of novel oxoisoaporphine derivatives as dual inhibitors for cholinesterases and amyloid beta aggregation" @default.
• W2068404502 cites W1971048984 @default.
• W2068404502 cites W1975944959 @default.
• W2068404502 cites W1981576090 @default.
• W2068404502 cites W1993672505 @default.
• W2068404502 cites W2010426046 @default.
• W2068404502 cites W2016698723 @default.
• W2068404502 cites W2017857494 @default.
• W2068404502 cites W2020067221 @default.
• W2068404502 cites W2027060039 @default.
• W2068404502 cites W2056687501 @default.
• W2068404502 cites W2058840940 @default.
• W2068404502 cites W2059304365 @default.
• W2068404502 cites W2062072233 @default.
• W2068404502 cites W2069440490 @default.
• W2068404502 cites W2078929643 @default.
• W2068404502 cites W2079711828 @default.
• W2068404502 cites W2084133260 @default.
• W2068404502 cites W2084972185 @default.
• W2068404502 cites W2094181196 @default.
• W2068404502 cites W2098277049 @default.
• W2068404502 cites W2121753059 @default.
• W2068404502 cites W2128671521 @default.
• W2068404502 cites W2146588392 @default.
• W2068404502 cites W2155039139 @default.
• W2068404502 cites W4234060991 @default.
• W2068404502 cites W2058049108 @default.
• W2068404502 doi "https://doi.org/10.1016/j.ejmech.2011.02.005" @default.
• W2068404502 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21367493" @default.
• W2068404502 hasPublicationYear "2011" @default.
• W2068404502 type Work @default.
• W2068404502 sameAs 2068404502 @default.
• W2068404502 citedByCount "25" @default.
• W2068404502 countsByYear W20684045022012 @default.
• W2068404502 countsByYear W20684045022013 @default.
• W2068404502 countsByYear W20684045022014 @default.
• W2068404502 countsByYear W20684045022015 @default.
• W2068404502 countsByYear W20684045022016 @default.
• W2068404502 countsByYear W20684045022018 @default.
• W2068404502 countsByYear W20684045022019 @default.
• W2068404502 countsByYear W20684045022020 @default.
• W2068404502 countsByYear W20684045022022 @default.
• W2068404502 crossrefType "journal-article" @default.
• W2068404502 hasAuthorship W2068404502A5004244292 @default.
• W2068404502 hasAuthorship W2068404502A5009900444 @default.
• W2068404502 hasAuthorship W2068404502A5017231732 @default.
• W2068404502 hasAuthorship W2068404502A5017464022 @default.
• W2068404502 hasAuthorship W2068404502A5023832499 @default.
• W2068404502 hasAuthorship W2068404502A5032782538 @default.
• W2068404502 hasAuthorship W2068404502A5042772858 @default.
• W2068404502 hasAuthorship W2068404502A5047620512 @default.
• W2068404502 hasAuthorship W2068404502A5059184457 @default.
• W2068404502 hasAuthorship W2068404502A5080622742 @default.
• W2068404502 hasAuthorship W2068404502A5082251778 @default.
• W2068404502 hasConcept C118792377 @default.
• W2068404502 hasConcept C161790260 @default.
• W2068404502 hasConcept C179104552 @default.
• W2068404502 hasConcept C181199279 @default.
• W2068404502 hasConcept C185592680 @default.
• W2068404502 hasConcept C193042331 @default.
• W2068404502 hasConcept C202751555 @default.
• W2068404502 hasConcept C2777633098 @default.
• W2068404502 hasConcept C2777752497 @default.
• W2068404502 hasConcept C2778816929 @default.
• W2068404502 hasConcept C2779059548 @default.
• W2068404502 hasConcept C31896038 @default.
• W2068404502 hasConcept C55493867 @default.
• W2068404502 hasConcept C71240020 @default.
• W2068404502 hasConcept C71924100 @default.
• W2068404502 hasConcept C98274493 @default.
• W2068404502 hasConceptScore W2068404502C118792377 @default.
• W2068404502 hasConceptScore W2068404502C161790260 @default.
• W2068404502 hasConceptScore W2068404502C179104552 @default.
• W2068404502 hasConceptScore W2068404502C181199279 @default.
• W2068404502 hasConceptScore W2068404502C185592680 @default.
• W2068404502 hasConceptScore W2068404502C193042331 @default.
• W2068404502 hasConceptScore W2068404502C202751555 @default.
• W2068404502 hasConceptScore W2068404502C2777633098 @default.
• W2068404502 hasConceptScore W2068404502C2777752497 @default.
• W2068404502 hasConceptScore W2068404502C2778816929 @default.
• W2068404502 hasConceptScore W2068404502C2779059548 @default.
• W2068404502 hasConceptScore W2068404502C31896038 @default.
• W2068404502 hasConceptScore W2068404502C55493867 @default.

• next