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- W2068408065 abstract "A TP-binding cassette (ABC) multidrug transporters are cellular efflux pumps with broad and often widely overlapping substrate specificities. They can have a major impact on the pharmacokinetics and hence overall pharmacological behavior of many drugs. To study their separate roles and functional overlap, or complementarity, a collection of mice deficient in two or more ABC transporters has been generated. This review discusses recent findings obtained with these models, focusing on pharmacokinetic studies with a number of clinically relevant drugs. In addition, the characterization of these mice and some physiological aspects of ABC multidrug transporters are addressed." @default.
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- W2068408065 date "2009-06-01" @default.
- W2068408065 modified "2023-09-30" @default.
- W2068408065 title "Pharmacokinetic Assessment of Multiple ATP-binding Cassette Transporters: The Power of Combination Knockout Mice" @default.
- W2068408065 doi "https://doi.org/10.1124/mi.9.3.7" @default.
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