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- W2068408977 abstract "The effects of local anesthetics on amino acid-induced currents were examined using the whole-cell configuration of the patch clamp technique in dissociated hippocampal pyramidal neurons of the rat. Lidocaine (3 mM) decreased the glycine-induced Cl− current (Gly-ICl) more potently (to 46% of the control value) than the γ-aminobutyric acid-induced Cl− current (GABA-ICl; to 75%), whereas the agent had little effect on the excitatory glutamate response. The reduction in the Gly-ICl was dose-dependent, with a dissociation constant (KD) of 3 mM and a Hill coefficient of 0.96. A non-competitive inhibition was suggested by a double reciprocal plot of the effects of lidocaine on the concentration-response curve of the Gly-ICl. Benzocaine, a neutral local anesthetic at physiological pH, decreased the Gly-ICl more potently than lidocaine, while QX314, a permanently charged quaternary derivative of lidocaine, produced a much smaller inhibition, thereby indicating that the neutral form of local anesthetics is more effective in reducing the Gly-ICl. The depression of the Gly-ICl and GABA-ICl in central neurons may contribute to local anesthetic-induced convulsions." @default.
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- W2068408977 date "1995-09-01" @default.
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- W2068408977 title "Local anesthetics reduce the inhibitory neurotransmitter-induced current in dissociated hippocampal neurons of the rat" @default.
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- W2068408977 doi "https://doi.org/10.1016/0014-2999(95)00293-t" @default.
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