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- W2068412994 abstract "Sir, We read with great interest the article by Desruelles et al.1 in which the authors suggested that a minimum dosage of 30 mg per day of nicorandil may be necessary to induce oral ulceration. However, we would suggest that oral ulceration and laryngeal inflammation can occur even at lower doses of nicorandil. A 62‐year‐old man was referred to our hospital with a 1‐year history of persistent and painful ulcerative lesions at the dorsal tongue and buccal mucosa, which had resulted in significant functional impairments such as difficulty in eating and swallowing since 2002. He had no previous history of oral ulceration or allergic disorders. His oral ulcers had been recalcitrant and showed a relapsing course. Before admission, treatment with local and systemic glucocorticoids had failed to induce healing. He had been treated empirically from January 2003 with itraconazole 100 mg daily, without benefit. He had been diagnosed as having angina pectoris 2 years previously, followed by percutaneous transluminal coronary angioplasty. He had been on daily medication with aspirin 100 mg, isosorbide mononitrate 60 mg, cilostazol 100 mg and nicorandil 10 mg for 1 year, under the care of a cardiologist." @default.
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- W2068412994 date "2004-10-01" @default.
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- W2068412994 title "A case of severe tongue ulceration and laryngeal inflammation induced by low-dose nicorandil therapy" @default.
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- W2068412994 doi "https://doi.org/10.1111/j.1365-2133.2004.06199.x" @default.
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