FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2068423301> ?p ?o ?g. }

• W2068423301 endingPage "1317" @default.
• W2068423301 startingPage "1312" @default.
• W2068423301 abstract "Notch signaling regulates key developmental events, and aberrant Notch signaling has been linked to disease. The structure of a dimeric Notch transcription complex with DNA is presented, revealing how dimer-binding sites with different spacers may be recognized. Cryptic dimer-binding sites are also uncovered, which might account for differential sensitivity of promoters to cooperative assembly of complexes. Ligand-induced proteolysis of Notch produces an intracellular effector domain that transduces essential signals by regulating the transcription of target genes. This function relies on the formation of transcriptional activation complexes that include intracellular Notch, a Mastermind co-activator and the transcription factor CSL bound to cognate DNA. These complexes form higher-order assemblies on paired, head-to-head CSL recognition sites. Here we report the X-ray structure of a dimeric human Notch1 transcription complex loaded on the paired site from the human HES1 promoter. The small interface between the Notch ankyrin domains could accommodate DNA bending and untwisting to allow a range of spacer lengths between the two sites. Cooperative dimerization occurred on the human and mouse Hes5 promoters at a sequence that diverged from the CSL-binding consensus at one of the sites. These studies reveal how promoter organizational features control cooperativity and, thus, the responsiveness of different promoters to Notch signaling." @default.
• W2068423301 created "2016-06-24" @default.
• W2068423301 creator A5016232259 @default.
• W2068423301 creator A5029821721 @default.
• W2068423301 creator A5040994803 @default.
• W2068423301 creator A5053973336 @default.
• W2068423301 creator A5066311698 @default.
• W2068423301 creator A5068628940 @default.
• W2068423301 creator A5088922644 @default.
• W2068423301 date "2010-10-24" @default.
• W2068423301 modified "2023-10-11" @default.
• W2068423301 title "Structural and mechanistic insights into cooperative assembly of dimeric Notch transcription complexes" @default.
• W2068423301 cites W1488144685 @default.
• W2068423301 cites W1508234976 @default.
• W2068423301 cites W1534001036 @default.
• W2068423301 cites W1595935608 @default.
• W2068423301 cites W1651300485 @default.
• W2068423301 cites W1655397332 @default.
• W2068423301 cites W1660631781 @default.
• W2068423301 cites W1675105744 @default.
• W2068423301 cites W1982866060 @default.
• W2068423301 cites W1996927159 @default.
• W2068423301 cites W2000589976 @default.
• W2068423301 cites W2004465970 @default.
• W2068423301 cites W2006996147 @default.
• W2068423301 cites W2013732926 @default.
• W2068423301 cites W2017421343 @default.
• W2068423301 cites W2019007505 @default.
• W2068423301 cites W2029358883 @default.
• W2068423301 cites W2050662405 @default.
• W2068423301 cites W2071960538 @default.
• W2068423301 cites W2083280774 @default.
• W2068423301 cites W2086059239 @default.
• W2068423301 cites W2091513322 @default.
• W2068423301 cites W2098503611 @default.
• W2068423301 cites W2119489910 @default.
• W2068423301 cites W2120936186 @default.
• W2068423301 cites W2122571618 @default.
• W2068423301 cites W2125757476 @default.
• W2068423301 cites W2127125400 @default.
• W2068423301 cites W2129828870 @default.
• W2068423301 cites W2140173252 @default.
• W2068423301 cites W2144081223 @default.
• W2068423301 cites W2147810480 @default.
• W2068423301 cites W2148334975 @default.
• W2068423301 cites W2153395073 @default.
• W2068423301 cites W2157092908 @default.
• W2068423301 doi "https://doi.org/10.1038/nsmb.1938" @default.
• W2068423301 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3024583" @default.
• W2068423301 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20972443" @default.
• W2068423301 hasPublicationYear "2010" @default.
• W2068423301 type Work @default.
• W2068423301 sameAs 2068423301 @default.
• W2068423301 citedByCount "108" @default.
• W2068423301 countsByYear W20684233012012 @default.
• W2068423301 countsByYear W20684233012013 @default.
• W2068423301 countsByYear W20684233012014 @default.
• W2068423301 countsByYear W20684233012015 @default.
• W2068423301 countsByYear W20684233012016 @default.
• W2068423301 countsByYear W20684233012017 @default.
• W2068423301 countsByYear W20684233012018 @default.
• W2068423301 countsByYear W20684233012019 @default.
• W2068423301 countsByYear W20684233012020 @default.
• W2068423301 countsByYear W20684233012021 @default.
• W2068423301 countsByYear W20684233012022 @default.
• W2068423301 countsByYear W20684233012023 @default.
• W2068423301 crossrefType "journal-article" @default.
• W2068423301 hasAuthorship W2068423301A5016232259 @default.
• W2068423301 hasAuthorship W2068423301A5029821721 @default.
• W2068423301 hasAuthorship W2068423301A5040994803 @default.
• W2068423301 hasAuthorship W2068423301A5053973336 @default.
• W2068423301 hasAuthorship W2068423301A5066311698 @default.
• W2068423301 hasAuthorship W2068423301A5068628940 @default.
• W2068423301 hasAuthorship W2068423301A5088922644 @default.
• W2068423301 hasBestOaLocation W20684233012 @default.
• W2068423301 hasConcept C101762097 @default.
• W2068423301 hasConcept C104317684 @default.
• W2068423301 hasConcept C107824862 @default.
• W2068423301 hasConcept C113241181 @default.
• W2068423301 hasConcept C138885662 @default.
• W2068423301 hasConcept C150194340 @default.
• W2068423301 hasConcept C161879069 @default.
• W2068423301 hasConcept C179926584 @default.
• W2068423301 hasConcept C188740287 @default.
• W2068423301 hasConcept C202769670 @default.
• W2068423301 hasConcept C2780645649 @default.
• W2068423301 hasConcept C41895202 @default.
• W2068423301 hasConcept C54355233 @default.
• W2068423301 hasConcept C62478195 @default.
• W2068423301 hasConcept C86339819 @default.
• W2068423301 hasConcept C86803240 @default.
• W2068423301 hasConcept C95444343 @default.
• W2068423301 hasConceptScore W2068423301C101762097 @default.
• W2068423301 hasConceptScore W2068423301C104317684 @default.
• W2068423301 hasConceptScore W2068423301C107824862 @default.
• W2068423301 hasConceptScore W2068423301C113241181 @default.
• W2068423301 hasConceptScore W2068423301C138885662 @default.
• W2068423301 hasConceptScore W2068423301C150194340 @default.

• next