FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2068423670> ?p ?o ?g. }

• W2068423670 endingPage "320" @default.
• W2068423670 startingPage "309" @default.
• W2068423670 abstract "Nitroaromatic compounds, ArNO2 have widespread actual or potential use in medicine and cancer therapy. There is direct proof that free-radical metabolites are involved in many applications, and an appreciation of the conceptual basis for their therapeutic differential; however, an understanding of the detailed mechanisms involved is lacking. Redox properties control most biological responses of nitro compounds, and the characteristics of the one-electron couple: ArNO2/ArNO2- are detailed. The futile metabolism of nitroaryl compounds characteristic of most aerobic nitroreductase systems reflects competition between natural radical-decay pathways and a one-electron transfer reaction to yield superoxide ion, O2-. Prototropic properties control the rate of radical decay, and redox properties control the rate of electron transfer to O2 or other acceptors. There are clear parallels in the chemistry of ArNO2- and O2-. While nitro radicals have frequently been invoked as damaging species, they are very unreactive (except as simple reductants). It seems likely that reductive metabolism of nitroaryl compounds, although generally involving nitro radical-anions as obligate intermediates (and this is required for therapeutic selectivity towards anaerobes), results in biological damage via reductive metabolites of higher reduction order than the one-electron product." @default.
• W2068423670 created "2016-06-24" @default.
• W2068423670 creator A5033455586 @default.
• W2068423670 date "1985-12-01" @default.
• W2068423670 modified "2023-10-01" @default.
• W2068423670 title "Some reactions and properties of nitro radical-anions important in biology and medicine." @default.
• W2068423670 cites W1483035975 @default.
• W2068423670 cites W1496775241 @default.
• W2068423670 cites W1535367955 @default.
• W2068423670 cites W1580909913 @default.
• W2068423670 cites W1583993235 @default.
• W2068423670 cites W1594766402 @default.
• W2068423670 cites W1870430364 @default.
• W2068423670 cites W1879184430 @default.
• W2068423670 cites W1968061011 @default.
• W2068423670 cites W1971048320 @default.
• W2068423670 cites W1974427354 @default.
• W2068423670 cites W1979545146 @default.
• W2068423670 cites W1979931416 @default.
• W2068423670 cites W1980009829 @default.
• W2068423670 cites W1984915593 @default.
• W2068423670 cites W1988562128 @default.
• W2068423670 cites W1989305990 @default.
• W2068423670 cites W1989348732 @default.
• W2068423670 cites W1994498894 @default.
• W2068423670 cites W1996119200 @default.
• W2068423670 cites W2004312516 @default.
• W2068423670 cites W2012489033 @default.
• W2068423670 cites W2014166067 @default.
• W2068423670 cites W2023020137 @default.
• W2068423670 cites W2023183821 @default.
• W2068423670 cites W2028971130 @default.
• W2068423670 cites W2042808140 @default.
• W2068423670 cites W2044873877 @default.
• W2068423670 cites W2048195510 @default.
• W2068423670 cites W2056659011 @default.
• W2068423670 cites W2059599245 @default.
• W2068423670 cites W2062364439 @default.
• W2068423670 cites W2069877145 @default.
• W2068423670 cites W2071214503 @default.
• W2068423670 cites W2078539357 @default.
• W2068423670 cites W2080501796 @default.
• W2068423670 cites W2081404902 @default.
• W2068423670 cites W2085766204 @default.
• W2068423670 cites W2088029982 @default.
• W2068423670 cites W2091797614 @default.
• W2068423670 cites W2093346236 @default.
• W2068423670 cites W2099026107 @default.
• W2068423670 cites W2111975681 @default.
• W2068423670 cites W2117120027 @default.
• W2068423670 cites W2197531333 @default.
• W2068423670 cites W2307949872 @default.
• W2068423670 cites W2327107424 @default.
• W2068423670 cites W2341210692 @default.
• W2068423670 cites W2411959589 @default.
• W2068423670 cites W2413482835 @default.
• W2068423670 cites W4290683299 @default.
• W2068423670 cites W4302063025 @default.
• W2068423670 cites W897920673 @default.
• W2068423670 doi "https://doi.org/10.1289/ehp.8564309" @default.
• W2068423670 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1568617" @default.
• W2068423670 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3830700" @default.
• W2068423670 hasPublicationYear "1985" @default.
• W2068423670 type Work @default.
• W2068423670 sameAs 2068423670 @default.
• W2068423670 citedByCount "147" @default.
• W2068423670 countsByYear W20684236702012 @default.
• W2068423670 countsByYear W20684236702013 @default.
• W2068423670 countsByYear W20684236702014 @default.
• W2068423670 countsByYear W20684236702015 @default.
• W2068423670 countsByYear W20684236702016 @default.
• W2068423670 countsByYear W20684236702017 @default.
• W2068423670 countsByYear W20684236702018 @default.
• W2068423670 countsByYear W20684236702019 @default.
• W2068423670 countsByYear W20684236702020 @default.
• W2068423670 countsByYear W20684236702021 @default.
• W2068423670 countsByYear W20684236702022 @default.
• W2068423670 countsByYear W20684236702023 @default.
• W2068423670 crossrefType "journal-article" @default.
• W2068423670 hasAuthorship W2068423670A5033455586 @default.
• W2068423670 hasBestOaLocation W20684236701 @default.
• W2068423670 hasConcept C123669783 @default.
• W2068423670 hasConcept C134121241 @default.
• W2068423670 hasConcept C139066938 @default.
• W2068423670 hasConcept C178790620 @default.
• W2068423670 hasConcept C181199279 @default.
• W2068423670 hasConcept C185592680 @default.
• W2068423670 hasConcept C191897082 @default.
• W2068423670 hasConcept C192562407 @default.
• W2068423670 hasConcept C21951064 @default.
• W2068423670 hasConcept C2780263894 @default.
• W2068423670 hasConcept C2780554229 @default.
• W2068423670 hasConcept C2780639532 @default.
• W2068423670 hasConcept C2780795997 @default.
• W2068423670 hasConcept C2781326480 @default.
• W2068423670 hasConcept C55904794 @default.
• W2068423670 hasConcept C75473681 @default.
• W2068423670 hasConceptScore W2068423670C123669783 @default.

• next