FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2068425191> ?p ?o ?g. }

• W2068425191 abstract "Abstract The study of the sequence of purine nucleotides in deoxyribonucleic acids requires the availability of suitable preparations of apyrimidinic acid, i.e., of polydeoxyribophosphate chains retaining the purines of the parent DNA in unchanged sequence and proportions. For an understanding of the degradation of DNA a detailed knowledge and a complete balance of the hydrazinolysis of pyrimidine deoxyribomononucleotides were required. The course and the rate of the degradation by hydrazine of thymidylic and deoxycytidylic acids were studied under a variety of conditions. These nucleotides, when treated with anhydrous hydrazine, give rise to stoichiometric amounts of (a) urea; (b) the hydrazone of 2-deoxyribophosphate; and (c) a heterocyclic compound. The latter is 4-methyl-5-pyrazolone in the case of thymidylic acid, and 3(5)-amino-pyrazole in the case of deoxycytidylic acid. The hydrazone of the sugar phosphate is cleaved quantitatively with benzaldehyde to yield 2-deoxyribophosphate and benzalazine. The various breakdown products were identified by comparison with authentic preparations. The first-order reaction of the degradation with anhydrous hydrazine is completed at 60° within 1.5 h for deoxycytidylic acid and within 4 h for thymidylic acid. At 40°, the time required for completion is about 4 times as long. Other orienting experiments demonstrated that purine deoxyribonucleotides withstand the treatment with hydrazine; that aqueous hydrazine solutions at various pH values effect a slower and irregular degradation; and that the replacement of hydrazine by monosubstituted hydrazine derivatives, such as phenyl- or methylhydrazine does not yield the desired results." @default.
• W2068425191 created "2016-06-24" @default.
• W2068425191 creator A5006973597 @default.
• W2068425191 creator A5015436518 @default.
• W2068425191 creator A5019552217 @default.
• W2068425191 creator A5025925554 @default.
• W2068425191 creator A5028986823 @default.
• W2068425191 date "1964-11-01" @default.
• W2068425191 modified "2023-09-26" @default.
• W2068425191 title "Studies on the nucleotide arrangement in deoxyribonucleic acids IX. Selective degradation of pyrimidine deoxyribonucleotides" @default.
• W2068425191 cites W1488075232 @default.
• W2068425191 cites W1605975645 @default.
• W2068425191 cites W165403903 @default.
• W2068425191 cites W184192874 @default.
• W2068425191 cites W1875166367 @default.
• W2068425191 cites W1906197854 @default.
• W2068425191 cites W1988772849 @default.
• W2068425191 cites W2003108286 @default.
• W2068425191 cites W2005822883 @default.
• W2068425191 cites W2009523327 @default.
• W2068425191 cites W2013537975 @default.
• W2068425191 cites W2018488989 @default.
• W2068425191 cites W2022111396 @default.
• W2068425191 cites W2027455009 @default.
• W2068425191 cites W2048443065 @default.
• W2068425191 cites W2086064046 @default.
• W2068425191 cites W2088567726 @default.
• W2068425191 cites W2095714597 @default.
• W2068425191 cites W2103103831 @default.
• W2068425191 cites W2108547497 @default.
• W2068425191 cites W2119116080 @default.
• W2068425191 cites W2132095354 @default.
• W2068425191 cites W2312591307 @default.
• W2068425191 cites W2399714544 @default.
• W2068425191 cites W2416088048 @default.
• W2068425191 cites W2437374451 @default.
• W2068425191 cites W4246808830 @default.
• W2068425191 cites W76141014 @default.
• W2068425191 doi "https://doi.org/10.1016/0926-6550(64)90076-3" @default.
• W2068425191 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14254018" @default.
• W2068425191 hasPublicationYear "1964" @default.
• W2068425191 type Work @default.
• W2068425191 sameAs 2068425191 @default.
• W2068425191 citedByCount "12" @default.
• W2068425191 crossrefType "journal-article" @default.
• W2068425191 hasAuthorship W2068425191A5006973597 @default.
• W2068425191 hasAuthorship W2068425191A5015436518 @default.
• W2068425191 hasAuthorship W2068425191A5019552217 @default.
• W2068425191 hasAuthorship W2068425191A5025925554 @default.
• W2068425191 hasAuthorship W2068425191A5028986823 @default.
• W2068425191 hasConcept C104317684 @default.
• W2068425191 hasConcept C178790620 @default.
• W2068425191 hasConcept C185592680 @default.
• W2068425191 hasConcept C187714232 @default.
• W2068425191 hasConcept C2776597398 @default.
• W2068425191 hasConcept C2779321679 @default.
• W2068425191 hasConcept C2780349576 @default.
• W2068425191 hasConcept C2908896964 @default.
• W2068425191 hasConcept C2910443878 @default.
• W2068425191 hasConcept C512185932 @default.
• W2068425191 hasConcept C55493867 @default.
• W2068425191 hasConcept C71240020 @default.
• W2068425191 hasConcept C76737569 @default.
• W2068425191 hasConceptScore W2068425191C104317684 @default.
• W2068425191 hasConceptScore W2068425191C178790620 @default.
• W2068425191 hasConceptScore W2068425191C185592680 @default.
• W2068425191 hasConceptScore W2068425191C187714232 @default.
• W2068425191 hasConceptScore W2068425191C2776597398 @default.
• W2068425191 hasConceptScore W2068425191C2779321679 @default.
• W2068425191 hasConceptScore W2068425191C2780349576 @default.
• W2068425191 hasConceptScore W2068425191C2908896964 @default.
• W2068425191 hasConceptScore W2068425191C2910443878 @default.
• W2068425191 hasConceptScore W2068425191C512185932 @default.
• W2068425191 hasConceptScore W2068425191C55493867 @default.
• W2068425191 hasConceptScore W2068425191C71240020 @default.
• W2068425191 hasConceptScore W2068425191C76737569 @default.
• W2068425191 hasLocation W20684251911 @default.
• W2068425191 hasLocation W20684251912 @default.
• W2068425191 hasOpenAccess W2068425191 @default.
• W2068425191 hasPrimaryLocation W20684251911 @default.
• W2068425191 hasRelatedWork W110943838 @default.
• W2068425191 hasRelatedWork W1906197854 @default.
• W2068425191 hasRelatedWork W1988772849 @default.
• W2068425191 hasRelatedWork W2003108286 @default.
• W2068425191 hasRelatedWork W2009523327 @default.
• W2068425191 hasRelatedWork W2013537975 @default.
• W2068425191 hasRelatedWork W2027455009 @default.
• W2068425191 hasRelatedWork W2027478357 @default.
• W2068425191 hasRelatedWork W2035768135 @default.
• W2068425191 hasRelatedWork W2051740023 @default.
• W2068425191 hasRelatedWork W2053232581 @default.
• W2068425191 hasRelatedWork W2064910835 @default.
• W2068425191 hasRelatedWork W2090379946 @default.
• W2068425191 hasRelatedWork W2091136150 @default.
• W2068425191 hasRelatedWork W2280568339 @default.
• W2068425191 hasRelatedWork W2396098465 @default.
• W2068425191 hasRelatedWork W2412170275 @default.
• W2068425191 hasRelatedWork W2983850269 @default.
• W2068425191 hasRelatedWork W317410057 @default.
• W2068425191 hasRelatedWork W76141014 @default.

• next