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- W2068429101 abstract "The protein C anticoagulant pathway plays a crucial role as a regulator of the blood clotting cascade. Protein C is activated on the vascular endothelial cell membrane by the thrombin-thrombomodulin complex. The endothelial protein C receptor binds protein C and further enhances protein C activation. Once formed, activated protein C down-regulates thrombin formation by inactivating factors Va and VIIIa and exerts cytoprotective effects through endothelial protein C receptor binding. An adequate generation of activated protein C depends on the precise assembly, on the surface of the endothelial cells, of thrombin, thrombomodulin, protein C, and endothelial protein C receptor. Therefore, any change in the efficiency of this assembly may cause a reduction or increase in activated protein C generation and modulate the risk of thrombosis. This review highlights the role of the endothelial protein C receptor in disease and discusses the association of its mutations with the risk of thrombosis." @default.
- W2068429101 created "2016-06-24" @default.
- W2068429101 creator A5005132007 @default.
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- W2068429101 creator A5068695724 @default.
- W2068429101 creator A5079018683 @default.
- W2068429101 creator A5085399576 @default.
- W2068429101 date "2011-11-01" @default.
- W2068429101 modified "2023-10-16" @default.
- W2068429101 title "The endothelial cell protein C receptor: Its role in thrombosis" @default.
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