Matches in SemOpenAlex for { <https://semopenalex.org/work/W2068436603> ?p ?o ?g. }
Showing items 1 to 84 of
84
with 100 items per page.
- W2068436603 abstract "Intracisternal (IC) injection of the GABA-transaminase inhibitor, ethanolamine-O-sulfate (EOS), has been previously shown to induce dose-dependent anorexia in normal rats as well as to reverse overeating in several rodent models of acute and chronic hyperphagia. To determine if such anorexia might be mediated by cells within or fibers of passage which traverse the lateral hypothalamus (LH), adult female rats received bilateral radiofrequency heat lesions of the LH vs. anesthesia control injections and were allowed to recover normal feeding and drinking responses. Using a longitudinal design, all animals then received 100, 0, and 200 micrograms EOS in 20 microliters deionized water IC with 1 week separating each injection. In addition to daily measures of feeding, drinking and body weight, all animals were screened 24 hr after injections for sensorimotor competence and general health by testing open-field activity, catalepsy, paw-lick responses on a hot-plate and rectal temperature. As reported previously, IC EOS induced dose-dependent hypophagia and weight loss. However, the magnitude and duration of these effects were equivalent in lesioned and control rats. In addition, open-field activity and body temperature were reliably lowered as a function of dosage while catalepsy was increased. Again, this effect was equivalent in lesioned and control rats. Subsequent tests of drinking and feeding in response to hyperosmotic and hypoglycemic challenges, respectively, confirmed that lesioned rats were deficient compared to controls. These findings suggest that an intact LH axis is not required for the anorexigenic effects of IC EOS." @default.
- W2068436603 created "2016-06-24" @default.
- W2068436603 creator A5051450477 @default.
- W2068436603 creator A5059110835 @default.
- W2068436603 date "1989-01-01" @default.
- W2068436603 modified "2023-10-16" @default.
- W2068436603 title "Effects of lateral hypothalamic lesions on the anorexia induced by ethanolamine-O-sulfate" @default.
- W2068436603 cites W1526596922 @default.
- W2068436603 cites W1966990176 @default.
- W2068436603 cites W1967908972 @default.
- W2068436603 cites W1982786179 @default.
- W2068436603 cites W1988273890 @default.
- W2068436603 cites W1994450708 @default.
- W2068436603 cites W1996803037 @default.
- W2068436603 cites W2010984488 @default.
- W2068436603 cites W2011072148 @default.
- W2068436603 cites W2017452805 @default.
- W2068436603 cites W2018203789 @default.
- W2068436603 cites W2021201255 @default.
- W2068436603 cites W2023830693 @default.
- W2068436603 cites W2029177952 @default.
- W2068436603 cites W2038269646 @default.
- W2068436603 cites W2054317535 @default.
- W2068436603 cites W2057776826 @default.
- W2068436603 cites W2064519907 @default.
- W2068436603 cites W2399141921 @default.
- W2068436603 cites W2417633626 @default.
- W2068436603 doi "https://doi.org/10.1016/0091-3057(89)90244-x" @default.
- W2068436603 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2734338" @default.
- W2068436603 hasPublicationYear "1989" @default.
- W2068436603 type Work @default.
- W2068436603 sameAs 2068436603 @default.
- W2068436603 citedByCount "3" @default.
- W2068436603 crossrefType "journal-article" @default.
- W2068436603 hasAuthorship W2068436603A5051450477 @default.
- W2068436603 hasAuthorship W2068436603A5059110835 @default.
- W2068436603 hasConcept C126322002 @default.
- W2068436603 hasConcept C134018914 @default.
- W2068436603 hasConcept C185592680 @default.
- W2068436603 hasConcept C2776669363 @default.
- W2068436603 hasConcept C2777003273 @default.
- W2068436603 hasConcept C2778654693 @default.
- W2068436603 hasConcept C2779085643 @default.
- W2068436603 hasConcept C2780062018 @default.
- W2068436603 hasConcept C2780159080 @default.
- W2068436603 hasConcept C2780476085 @default.
- W2068436603 hasConcept C2780714764 @default.
- W2068436603 hasConcept C2780948584 @default.
- W2068436603 hasConcept C2909274461 @default.
- W2068436603 hasConcept C513476851 @default.
- W2068436603 hasConcept C71924100 @default.
- W2068436603 hasConceptScore W2068436603C126322002 @default.
- W2068436603 hasConceptScore W2068436603C134018914 @default.
- W2068436603 hasConceptScore W2068436603C185592680 @default.
- W2068436603 hasConceptScore W2068436603C2776669363 @default.
- W2068436603 hasConceptScore W2068436603C2777003273 @default.
- W2068436603 hasConceptScore W2068436603C2778654693 @default.
- W2068436603 hasConceptScore W2068436603C2779085643 @default.
- W2068436603 hasConceptScore W2068436603C2780062018 @default.
- W2068436603 hasConceptScore W2068436603C2780159080 @default.
- W2068436603 hasConceptScore W2068436603C2780476085 @default.
- W2068436603 hasConceptScore W2068436603C2780714764 @default.
- W2068436603 hasConceptScore W2068436603C2780948584 @default.
- W2068436603 hasConceptScore W2068436603C2909274461 @default.
- W2068436603 hasConceptScore W2068436603C513476851 @default.
- W2068436603 hasConceptScore W2068436603C71924100 @default.
- W2068436603 hasLocation W20684366031 @default.
- W2068436603 hasLocation W20684366032 @default.
- W2068436603 hasOpenAccess W2068436603 @default.
- W2068436603 hasPrimaryLocation W20684366031 @default.
- W2068436603 hasRelatedWork W1987530196 @default.
- W2068436603 hasRelatedWork W2010961175 @default.
- W2068436603 hasRelatedWork W2030769789 @default.
- W2068436603 hasRelatedWork W2062084912 @default.
- W2068436603 hasRelatedWork W2068436603 @default.
- W2068436603 hasRelatedWork W2078989286 @default.
- W2068436603 hasRelatedWork W2126235746 @default.
- W2068436603 hasRelatedWork W2267586012 @default.
- W2068436603 hasRelatedWork W2357273652 @default.
- W2068436603 hasRelatedWork W2773858965 @default.
- W2068436603 isParatext "false" @default.
- W2068436603 isRetracted "false" @default.
- W2068436603 magId "2068436603" @default.
- W2068436603 workType "article" @default.