Matches in SemOpenAlex for { <https://semopenalex.org/work/W2068440180> ?p ?o ?g. }
- W2068440180 endingPage "213" @default.
- W2068440180 startingPage "209" @default.
- W2068440180 abstract "Inherited variance in the IL-12B gene is associated with susceptibility to Chlamydia trachomatis-induced tubal factor infertility and disease severity. In this study, our aim was to discover how polymorphisms in IL-12-coding genes influence C. trachomatis-induced immune responses and IL-12 production. The study population consisted of 240 women. IL-12A and IL-12B single nucleotide polymorphisms (SNPs) were determined from isolated DNA using the Sequenom system with matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry. We studied lymphocyte proliferative (LP) responses to C. trachomatis strains E and F elementary bodies (EBs) and recombinant chlamydial heat-shock protein 60 (CHSP60) antigen. IL-12p40 and IL-12p70 levels were measured using the BD Flex Set method. We found a statistically significant association between the C. trachomatis EB antigen-specific LP response and the rs2853694 SNP (P = 0.02). Our study demonstrates that the IL-12 cytokine family is involved in C. trachomatis-specific immune responses. Moreover, C. trachomatis-induced IL-12 production and the IL-12B rs2853694 SNP partially explain individual variation in the C. trachomatis LP response." @default.
- W2068440180 created "2016-06-24" @default.
- W2068440180 creator A5011453777 @default.
- W2068440180 creator A5012660812 @default.
- W2068440180 creator A5039377744 @default.
- W2068440180 creator A5044600248 @default.
- W2068440180 creator A5056751134 @default.
- W2068440180 creator A5071425228 @default.
- W2068440180 creator A5086891651 @default.
- W2068440180 creator A5088046394 @default.
- W2068440180 creator A5088225687 @default.
- W2068440180 date "2015-02-24" @default.
- W2068440180 modified "2023-09-24" @default.
- W2068440180 title "Contribution ofIL-12AandIL-12BPolymorphisms toChlamydia trachomatis-Specific Cell-Mediated Immune Responses" @default.
- W2068440180 cites W1969137358 @default.
- W2068440180 cites W1986567055 @default.
- W2068440180 cites W1993332259 @default.
- W2068440180 cites W1996992893 @default.
- W2068440180 cites W2002832195 @default.
- W2068440180 cites W2009219530 @default.
- W2068440180 cites W2016163378 @default.
- W2068440180 cites W2018311659 @default.
- W2068440180 cites W2023835902 @default.
- W2068440180 cites W2029961929 @default.
- W2068440180 cites W2057730362 @default.
- W2068440180 cites W2078457180 @default.
- W2068440180 cites W2082164539 @default.
- W2068440180 cites W2083151754 @default.
- W2068440180 cites W2104439753 @default.
- W2068440180 cites W2117723056 @default.
- W2068440180 cites W2121962863 @default.
- W2068440180 cites W2123356056 @default.
- W2068440180 cites W2124791953 @default.
- W2068440180 cites W2137273150 @default.
- W2068440180 cites W2148216817 @default.
- W2068440180 doi "https://doi.org/10.1111/sji.12264" @default.
- W2068440180 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25565213" @default.
- W2068440180 hasPublicationYear "2015" @default.
- W2068440180 type Work @default.
- W2068440180 sameAs 2068440180 @default.
- W2068440180 citedByCount "5" @default.
- W2068440180 countsByYear W20684401802015 @default.
- W2068440180 countsByYear W20684401802017 @default.
- W2068440180 countsByYear W20684401802018 @default.
- W2068440180 countsByYear W20684401802022 @default.
- W2068440180 crossrefType "journal-article" @default.
- W2068440180 hasAuthorship W2068440180A5011453777 @default.
- W2068440180 hasAuthorship W2068440180A5012660812 @default.
- W2068440180 hasAuthorship W2068440180A5039377744 @default.
- W2068440180 hasAuthorship W2068440180A5044600248 @default.
- W2068440180 hasAuthorship W2068440180A5056751134 @default.
- W2068440180 hasAuthorship W2068440180A5071425228 @default.
- W2068440180 hasAuthorship W2068440180A5086891651 @default.
- W2068440180 hasAuthorship W2068440180A5088046394 @default.
- W2068440180 hasAuthorship W2068440180A5088225687 @default.
- W2068440180 hasBestOaLocation W20684401801 @default.
- W2068440180 hasConcept C104317684 @default.
- W2068440180 hasConcept C135763542 @default.
- W2068440180 hasConcept C139275648 @default.
- W2068440180 hasConcept C147483822 @default.
- W2068440180 hasConcept C153209595 @default.
- W2068440180 hasConcept C203014093 @default.
- W2068440180 hasConcept C2777391075 @default.
- W2068440180 hasConcept C2908647359 @default.
- W2068440180 hasConcept C54355233 @default.
- W2068440180 hasConcept C71924100 @default.
- W2068440180 hasConcept C86803240 @default.
- W2068440180 hasConcept C8891405 @default.
- W2068440180 hasConcept C99454951 @default.
- W2068440180 hasConceptScore W2068440180C104317684 @default.
- W2068440180 hasConceptScore W2068440180C135763542 @default.
- W2068440180 hasConceptScore W2068440180C139275648 @default.
- W2068440180 hasConceptScore W2068440180C147483822 @default.
- W2068440180 hasConceptScore W2068440180C153209595 @default.
- W2068440180 hasConceptScore W2068440180C203014093 @default.
- W2068440180 hasConceptScore W2068440180C2777391075 @default.
- W2068440180 hasConceptScore W2068440180C2908647359 @default.
- W2068440180 hasConceptScore W2068440180C54355233 @default.
- W2068440180 hasConceptScore W2068440180C71924100 @default.
- W2068440180 hasConceptScore W2068440180C86803240 @default.
- W2068440180 hasConceptScore W2068440180C8891405 @default.
- W2068440180 hasConceptScore W2068440180C99454951 @default.
- W2068440180 hasFunder F4320307874 @default.
- W2068440180 hasIssue "3" @default.
- W2068440180 hasLocation W20684401801 @default.
- W2068440180 hasLocation W20684401802 @default.
- W2068440180 hasOpenAccess W2068440180 @default.
- W2068440180 hasPrimaryLocation W20684401801 @default.
- W2068440180 hasRelatedWork W1217682272 @default.
- W2068440180 hasRelatedWork W1984103522 @default.
- W2068440180 hasRelatedWork W2001055320 @default.
- W2068440180 hasRelatedWork W2031356189 @default.
- W2068440180 hasRelatedWork W2106074807 @default.
- W2068440180 hasRelatedWork W2149871822 @default.
- W2068440180 hasRelatedWork W2161110446 @default.
- W2068440180 hasRelatedWork W2220102944 @default.
- W2068440180 hasRelatedWork W2360982546 @default.
- W2068440180 hasRelatedWork W2409441623 @default.