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- W2068441555 endingPage "698" @default.
- W2068441555 startingPage "689" @default.
- W2068441555 abstract "Although early clinical observations implicated dopamine dysfunction in the neuropathology of schizophrenia, accumulating evidence suggests that multiple neurotransmitter pathways are dysregulated. The psychotomimetic actions of NMDA receptor antagonists point to an imbalance of glutamatergic signaling. Encouragingly, numerous preclinical and clinical studies have elucidated several potential targets for increasing NMDA receptor function and equilibrating glutamatergic tone, including the metabotropic glutamate receptors 2, 3 and 5, the muscarinic acetylcholine receptors M(1) and M(4), and the glycine transporter GlyT1. Highly specific allosteric and orthosteric ligands have been developed that modify the activity of these novel target proteins, and in this review we summarize both the glutamatergic mechanisms and the novel compounds that are increasing the promise for a multifaceted pharmacological approach to treat schizophrenia." @default.
- W2068441555 created "2016-06-24" @default.
- W2068441555 creator A5000101753 @default.
- W2068441555 creator A5015034189 @default.
- W2068441555 creator A5034463032 @default.
- W2068441555 date "2011-12-01" @default.
- W2068441555 modified "2023-10-13" @default.
- W2068441555 title "Targeting glutamate synapses in schizophrenia" @default.
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