FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2068442489> ?p ?o ?g. }

• W2068442489 endingPage "479" @default.
• W2068442489 startingPage "469" @default.
• W2068442489 abstract "Pseudomonas aeruginosa is a major opportunistic pathogen in immune-compromised individuals and cystic fibrosis patients. This organism stimulates a complex inflammatory response in the lung, including production of various cytokines and chemokines. The specific contribution of these mediators in the host defense against this bacterium has yet to be fully characterized. Interleukin-12 (IL-12) is commonly known as a master regulator of innate and adaptive immunity. IL-12 induces its biological effects through its associated intracellular signaling molecule, the signal transducer and activator of transcription 4 (STAT4). To examine a specific role of IL-12 and STAT4 in P. aeruginosa lung infection in mice, STAT4-deficient (STAT4−/−) and IL-12 p40-deficient (IL-12 p40−/−) mice were infected with P. aeruginosa intranasally. Interestingly, STAT4−/− mice, but not IL-12 p40−/− mice after 24 h infection showed impaired production of the pro-inflammatory cytokines tumor necrosis factor, interleukin-1β, and macrophage-inflammatory protein-2. However, neither STAT4 nor IL-12 p40 deficiency significantly affected INFγ production or bacterial clearance compared to wild-type mice. Similarly, neutrophil recruitment was not affected in the STAT4−/− and IL-12 p40−/− mice. These results suggest that STAT4 contributes to P. aeruginosa-induced inflammation, but it is not essential for bacterial clearance. Although IL-12 is essential for the host defense against various pathogens, this cytokine is likely not a major player in the host response to P. aeruginosa lung infection." @default.
• W2068442489 created "2016-06-24" @default.
• W2068442489 creator A5029808150 @default.
• W2068442489 creator A5053363766 @default.
• W2068442489 creator A5066366714 @default.
• W2068442489 creator A5087996488 @default.
• W2068442489 date "2008-07-01" @default.
• W2068442489 modified "2023-09-27" @default.
• W2068442489 title "Signal transducer and activator of transcription 4 (STAT4), but not IL-12 contributes to Pseudomonas aeruginosa-induced lung inflammation in mice" @default.
• W2068442489 cites W12119413 @default.
• W2068442489 cites W1534159754 @default.
• W2068442489 cites W1702969026 @default.
• W2068442489 cites W1765079284 @default.
• W2068442489 cites W1902787289 @default.
• W2068442489 cites W1958363133 @default.
• W2068442489 cites W1964464847 @default.
• W2068442489 cites W1966999437 @default.
• W2068442489 cites W1985890243 @default.
• W2068442489 cites W1987244430 @default.
• W2068442489 cites W2000022183 @default.
• W2068442489 cites W2002220979 @default.
• W2068442489 cites W2009219530 @default.
• W2068442489 cites W2015479125 @default.
• W2068442489 cites W2024581798 @default.
• W2068442489 cites W2035027025 @default.
• W2068442489 cites W2038312972 @default.
• W2068442489 cites W2044325609 @default.
• W2068442489 cites W2047310205 @default.
• W2068442489 cites W2066396134 @default.
• W2068442489 cites W2066484939 @default.
• W2068442489 cites W2067524407 @default.
• W2068442489 cites W2076383601 @default.
• W2068442489 cites W2087905758 @default.
• W2068442489 cites W2091272253 @default.
• W2068442489 cites W2105008011 @default.
• W2068442489 cites W2107033092 @default.
• W2068442489 cites W2119182059 @default.
• W2068442489 cites W2120738305 @default.
• W2068442489 cites W2126639608 @default.
• W2068442489 cites W2132938540 @default.
• W2068442489 cites W2133435354 @default.
• W2068442489 cites W2133922377 @default.
• W2068442489 cites W2140380036 @default.
• W2068442489 cites W2151608677 @default.
• W2068442489 cites W2152009213 @default.
• W2068442489 cites W2317451331 @default.
• W2068442489 doi "https://doi.org/10.1016/j.imbio.2007.11.007" @default.
• W2068442489 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18514749" @default.
• W2068442489 hasPublicationYear "2008" @default.
• W2068442489 type Work @default.
• W2068442489 sameAs 2068442489 @default.
• W2068442489 citedByCount "10" @default.
• W2068442489 countsByYear W20684424892018 @default.
• W2068442489 countsByYear W20684424892019 @default.
• W2068442489 countsByYear W20684424892020 @default.
• W2068442489 countsByYear W20684424892021 @default.
• W2068442489 countsByYear W20684424892022 @default.
• W2068442489 crossrefType "journal-article" @default.
• W2068442489 hasAuthorship W2068442489A5029808150 @default.
• W2068442489 hasAuthorship W2068442489A5053363766 @default.
• W2068442489 hasAuthorship W2068442489A5066366714 @default.
• W2068442489 hasAuthorship W2068442489A5087996488 @default.
• W2068442489 hasConcept C13373296 @default.
• W2068442489 hasConcept C171958077 @default.
• W2068442489 hasConcept C17991360 @default.
• W2068442489 hasConcept C203014093 @default.
• W2068442489 hasConcept C2776914184 @default.
• W2068442489 hasConcept C2777637488 @default.
• W2068442489 hasConcept C2778277574 @default.
• W2068442489 hasConcept C2778690821 @default.
• W2068442489 hasConcept C2778923194 @default.
• W2068442489 hasConcept C523546767 @default.
• W2068442489 hasConcept C54355233 @default.
• W2068442489 hasConcept C62478195 @default.
• W2068442489 hasConcept C65439459 @default.
• W2068442489 hasConcept C86803240 @default.
• W2068442489 hasConcept C8891405 @default.
• W2068442489 hasConcept C89423630 @default.
• W2068442489 hasConcept C95444343 @default.
• W2068442489 hasConceptScore W2068442489C13373296 @default.
• W2068442489 hasConceptScore W2068442489C171958077 @default.
• W2068442489 hasConceptScore W2068442489C17991360 @default.
• W2068442489 hasConceptScore W2068442489C203014093 @default.
• W2068442489 hasConceptScore W2068442489C2776914184 @default.
• W2068442489 hasConceptScore W2068442489C2777637488 @default.
• W2068442489 hasConceptScore W2068442489C2778277574 @default.
• W2068442489 hasConceptScore W2068442489C2778690821 @default.
• W2068442489 hasConceptScore W2068442489C2778923194 @default.
• W2068442489 hasConceptScore W2068442489C523546767 @default.
• W2068442489 hasConceptScore W2068442489C54355233 @default.
• W2068442489 hasConceptScore W2068442489C62478195 @default.
• W2068442489 hasConceptScore W2068442489C65439459 @default.
• W2068442489 hasConceptScore W2068442489C86803240 @default.
• W2068442489 hasConceptScore W2068442489C8891405 @default.
• W2068442489 hasConceptScore W2068442489C89423630 @default.
• W2068442489 hasConceptScore W2068442489C95444343 @default.
• W2068442489 hasIssue "6" @default.
• W2068442489 hasLocation W20684424891 @default.

• next