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- W2068442671 abstract "Heterozygosity for mutations in ribosomal protein genes frequently leads to a dominant phenotype of retarded growth and small adult bristles in Drosophila (the Minute phenotype). Cells with Minute genotypes are subject to cell competition, characterized by their selective apoptosis and removal in mosaic tissues that contain wild-type cells. Competitive apoptosis was found to depend on the pro-apoptotic reaper, grim and head involution defective genes but was independent of p53. Rp/+ cells are protected by anti-apoptotic baculovirus p35 expression but lacked the usual hallmarks of ‘undead’ cells. They lacked Dronc activity, and neither expression of dominant-negative Dronc nor dronc knockdown by dsRNA prevented competitive apoptosis, which also continued in dronc null mutant cells or in the absence of the initiator caspases dredd and dream/strica. Only simultaneous knockdown of dronc and dream/strica by dsRNA was sufficient to protect Rp/+ cells from competition. By contrast, Rp/Rp cells were also protected by baculovirus p35, but Rp/Rp death was dronc-dependent, and undead Rp/Rp cells exhibited typical dronc-dependent expression of Wingless. Independence of p53 and unusual dependence on Dream/Strica distinguish competitive cell death from noncompetitive apoptosis of Rp/Rp cells and from many other examples of cell death." @default.
- W2068442671 created "2016-06-24" @default.
- W2068442671 creator A5002565932 @default.
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- W2068442671 date "2015-01-23" @default.
- W2068442671 modified "2023-10-17" @default.
- W2068442671 title "Apoptotic mechanisms during competition of ribosomal protein mutant cells: roles of the initiator caspases Dronc and Dream/Strica" @default.
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- W2068442671 cites W1975902630 @default.
- W2068442671 cites W1976343472 @default.
- W2068442671 cites W1981253832 @default.
- W2068442671 cites W1984925149 @default.
- W2068442671 cites W1988036662 @default.
- W2068442671 cites W1992418538 @default.
- W2068442671 cites W1993790646 @default.
- W2068442671 cites W1997474381 @default.
- W2068442671 cites W2003749297 @default.
- W2068442671 cites W2003769148 @default.
- W2068442671 cites W2006997885 @default.
- W2068442671 cites W2008004544 @default.
- W2068442671 cites W2011282282 @default.
- W2068442671 cites W2011725556 @default.
- W2068442671 cites W2012898911 @default.
- W2068442671 cites W2014844816 @default.
- W2068442671 cites W2018761778 @default.
- W2068442671 cites W2021014123 @default.
- W2068442671 cites W2021338058 @default.
- W2068442671 cites W2021772999 @default.
- W2068442671 cites W2025693577 @default.
- W2068442671 cites W2027986342 @default.
- W2068442671 cites W2033474857 @default.
- W2068442671 cites W2035755740 @default.
- W2068442671 cites W2037546154 @default.
- W2068442671 cites W2042365294 @default.
- W2068442671 cites W2046666752 @default.
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- W2068442671 cites W2053586237 @default.
- W2068442671 cites W2059692650 @default.
- W2068442671 cites W2060839601 @default.
- W2068442671 cites W2062469875 @default.
- W2068442671 cites W2065418058 @default.
- W2068442671 cites W2065612659 @default.
- W2068442671 cites W2068774293 @default.
- W2068442671 cites W2069334879 @default.
- W2068442671 cites W2069673871 @default.
- W2068442671 cites W2070671255 @default.
- W2068442671 cites W2070847433 @default.
- W2068442671 cites W2074252560 @default.
- W2068442671 cites W2080419671 @default.
- W2068442671 cites W2086235418 @default.
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- W2068442671 cites W2091613928 @default.
- W2068442671 cites W2094214551 @default.
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- W2068442671 cites W2130828473 @default.
- W2068442671 cites W2136283919 @default.
- W2068442671 cites W2139587743 @default.
- W2068442671 cites W2150972545 @default.
- W2068442671 cites W2155327121 @default.
- W2068442671 cites W2155995453 @default.
- W2068442671 cites W2157310482 @default.
- W2068442671 cites W2159935247 @default.
- W2068442671 cites W2164293876 @default.
- W2068442671 cites W2165997736 @default.
- W2068442671 cites W2166863403 @default.
- W2068442671 cites W2167599188 @default.
- W2068442671 cites W2171572099 @default.
- W2068442671 cites W4232341174 @default.
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- W2068442671 doi "https://doi.org/10.1038/cdd.2014.218" @default.
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- W2068442671 hasPublicationYear "2015" @default.
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