FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2068442916> ?p ?o ?g. }

• W2068442916 endingPage "e370" @default.
• W2068442916 startingPage "e370" @default.
• W2068442916 abstract "Ability to adapt to conditions of limited nutrient supply requires a reorganization of the metabolic pathways to balance energy generation and production of biosynthetic intermediates. Several fast-growing cells overexpress the P2X7 receptor (P2X7R) for extracellular ATP. A feature of this receptor is to allow growth in the absence of serum. We show here that transfection of P2X7R allows proliferation of P2X7R-transfected HEK293 (HEK293-P2X7) cells not only in the absence of serum but also in low (4 mM) glucose, and increases lactate output compared with mock-transfected HEK293 (HEK293-mock) cells. In HEK293-P2X7, lactate output is further stimulated upon addition of exogenous ATP or the mitochondrial uncoupler carbonylcyanide p-trifluoromethoxyphenylhydrazone (FCCP). In the human neuroblastoma cell line ACN, lactate output is also dependent on P2X7R function. P2X7R-expressing cells upregulate (a) the glucose transporter Glut1, (b) the glycolytic enzymes glyceraldehyde 3-phosphate dehydrogenase (G3PDH), (c) phosphofructokinase (PFK), (d) pyruvate kinase M2 (PKM2) and (e) pyruvate dehydrogenase kinase 1 (PDHK1); furthermore, P2X7R expression (a) inhibits pyruvate dehydrogenase (PDH) activity, (b) increases phosphorylated Akt/PKB and hypoxia-inducible factor 1α (HIF-1α) expression and (c) enhances intracellular glycogen stores. In HEK293-P2X7 cells, glucose deprivation increases lactate production, expression of glycolytic enzymes and ph-Akt/PKB level. These data show that the P2X7R has an intrinsic ability to reprogram cell metabolism to meet the needs imposed by adverse environmental conditions." @default.
• W2068442916 created "2016-06-24" @default.
• W2068442916 creator A5003933043 @default.
• W2068442916 creator A5017383986 @default.
• W2068442916 creator A5017854085 @default.
• W2068442916 creator A5053938706 @default.
• W2068442916 creator A5056874156 @default.
• W2068442916 date "2012-08-16" @default.
• W2068442916 modified "2023-10-14" @default.
• W2068442916 title "The P2X7 receptor is a key modulator of aerobic glycolysis" @default.
• W2068442916 cites W1481135965 @default.
• W2068442916 cites W1532386517 @default.
• W2068442916 cites W1548145115 @default.
• W2068442916 cites W1833920545 @default.
• W2068442916 cites W1901584600 @default.
• W2068442916 cites W1917138271 @default.
• W2068442916 cites W1959848155 @default.
• W2068442916 cites W1993059138 @default.
• W2068442916 cites W1996799865 @default.
• W2068442916 cites W1998664010 @default.
• W2068442916 cites W2000988880 @default.
• W2068442916 cites W2001960844 @default.
• W2068442916 cites W2018612932 @default.
• W2068442916 cites W2020013385 @default.
• W2068442916 cites W2028897202 @default.
• W2068442916 cites W2029255902 @default.
• W2068442916 cites W2029642537 @default.
• W2068442916 cites W2032717943 @default.
• W2068442916 cites W2063193694 @default.
• W2068442916 cites W2067122631 @default.
• W2068442916 cites W2072023433 @default.
• W2068442916 cites W2072939418 @default.
• W2068442916 cites W2079197121 @default.
• W2068442916 cites W2080245613 @default.
• W2068442916 cites W2081929605 @default.
• W2068442916 cites W2092353041 @default.
• W2068442916 cites W2097259163 @default.
• W2068442916 cites W2101420246 @default.
• W2068442916 cites W2102943268 @default.
• W2068442916 cites W2104082830 @default.
• W2068442916 cites W2116371476 @default.
• W2068442916 cites W2117692326 @default.
• W2068442916 cites W2118112499 @default.
• W2068442916 cites W2122631210 @default.
• W2068442916 cites W2129898733 @default.
• W2068442916 cites W2130153302 @default.
• W2068442916 cites W2130255071 @default.
• W2068442916 cites W2136886131 @default.
• W2068442916 cites W2141869864 @default.
• W2068442916 cites W2145911009 @default.
• W2068442916 cites W2156991534 @default.
• W2068442916 cites W2159717790 @default.
• W2068442916 cites W2170260309 @default.
• W2068442916 cites W2358232982 @default.
• W2068442916 cites W4243903519 @default.
• W2068442916 cites W44963298 @default.
• W2068442916 doi "https://doi.org/10.1038/cddis.2012.105" @default.
• W2068442916 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3434661" @default.
• W2068442916 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22898868" @default.
• W2068442916 hasPublicationYear "2012" @default.
• W2068442916 type Work @default.
• W2068442916 sameAs 2068442916 @default.
• W2068442916 citedByCount "113" @default.
• W2068442916 countsByYear W20684429162013 @default.
• W2068442916 countsByYear W20684429162014 @default.
• W2068442916 countsByYear W20684429162015 @default.
• W2068442916 countsByYear W20684429162016 @default.
• W2068442916 countsByYear W20684429162017 @default.
• W2068442916 countsByYear W20684429162018 @default.
• W2068442916 countsByYear W20684429162019 @default.
• W2068442916 countsByYear W20684429162020 @default.
• W2068442916 countsByYear W20684429162021 @default.
• W2068442916 countsByYear W20684429162022 @default.
• W2068442916 countsByYear W20684429162023 @default.
• W2068442916 crossrefType "journal-article" @default.
• W2068442916 hasAuthorship W2068442916A5003933043 @default.
• W2068442916 hasAuthorship W2068442916A5017383986 @default.
• W2068442916 hasAuthorship W2068442916A5017854085 @default.
• W2068442916 hasAuthorship W2068442916A5053938706 @default.
• W2068442916 hasAuthorship W2068442916A5056874156 @default.
• W2068442916 hasBestOaLocation W20684429161 @default.
• W2068442916 hasConcept C104317684 @default.
• W2068442916 hasConcept C122245378 @default.
• W2068442916 hasConcept C134018914 @default.
• W2068442916 hasConcept C161573976 @default.
• W2068442916 hasConcept C170493617 @default.
• W2068442916 hasConcept C174510640 @default.
• W2068442916 hasConcept C20251656 @default.
• W2068442916 hasConcept C2777952866 @default.
• W2068442916 hasConcept C2779306644 @default.
• W2068442916 hasConcept C2780854706 @default.
• W2068442916 hasConcept C54009773 @default.
• W2068442916 hasConcept C55493867 @default.
• W2068442916 hasConcept C55885012 @default.
• W2068442916 hasConcept C62231903 @default.
• W2068442916 hasConcept C86803240 @default.
• W2068442916 hasConcept C95444343 @default.
• W2068442916 hasConceptScore W2068442916C104317684 @default.

• next