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• W2068467663 abstract "Aplastic anemia is a rare, serious disease characterized by hypocellular bone marrow and pancytopenia in the peripheral blood. Most cases are acquired, idiopathic, and without gross cytogenetic abnormalities. A few chromosome abnormalities have recurred among a small subset of patients, most commonly trisomy 8 and monosomy 7. Some of these chromosome abnormalities have prognostic and therapeutic significance, although for most the clinical relevance is not known. We present the case of a 40-year-old man with idiopathic severe aplastic anemia in bone marrow cells with trisomy of the whole long arm of chromosome 1 due to an unbalanced translocation between chromosomes 1 and 15 at breakpoints of q10 and 15q10. This clonal abnormality (which, to our knowledge, has not been previously reported in a patient with aplastic anemia) suggests that genes on 1q may be involved in marrow aplasia." @default.
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• W2068467663 date "2006-08-01" @default.
• W2068467663 modified "2023-09-25" @default.
• W2068467663 title "Trisomy 1q in a patient with severe aplastic anemia" @default.
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• W2068467663 doi "https://doi.org/10.1016/j.cancergencyto.2006.03.014" @default.
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