Matches in SemOpenAlex for { <https://semopenalex.org/work/W2068467995> ?p ?o ?g. }
- W2068467995 endingPage "235" @default.
- W2068467995 startingPage "221" @default.
- W2068467995 abstract "Extracellular collections of abnormal filaments composed of prion proteins have been identified in the brains of scrapie-infected hamsters using immunoelectron microscopy. Some of the filaments were 1500 nm in length; generally, they exhibited a uniform diameter of 16 nm. Rarely, the filaments had a twisted appearance, raising the possibility that they are flattened cylinders or are composed of helically wound protofilaments. The prion filaments possess the same diameter and limited twisting as the shorter rod-shaped particles observed in purified preparations of prions. Both the filaments and rods are composed of PrP 27–30 molecules, as determined by immunoelectron microscopy using affinity-purified antibodies. The ultrastructural features of the prion filaments are similar to those reported for amyloid in many tissues including brain. These results provide the first evidence that prion proteins assemble into filaments within the brain and that these filaments accumulate in extracellular spaces to form amyloid plaques." @default.
- W2068467995 created "2016-06-24" @default.
- W2068467995 creator A5014396482 @default.
- W2068467995 creator A5033786344 @default.
- W2068467995 creator A5062856449 @default.
- W2068467995 creator A5066185543 @default.
- W2068467995 creator A5088798867 @default.
- W2068467995 creator A5088931405 @default.
- W2068467995 date "1985-05-01" @default.
- W2068467995 modified "2023-10-17" @default.
- W2068467995 title "Identification of prion amyloid filaments in scrapie-infected brain" @default.
- W2068467995 cites W1480950303 @default.
- W2068467995 cites W1559478955 @default.
- W2068467995 cites W1566845757 @default.
- W2068467995 cites W1973758214 @default.
- W2068467995 cites W1973983122 @default.
- W2068467995 cites W1975723177 @default.
- W2068467995 cites W1977807250 @default.
- W2068467995 cites W1983773095 @default.
- W2068467995 cites W1983998410 @default.
- W2068467995 cites W1985991410 @default.
- W2068467995 cites W1987095955 @default.
- W2068467995 cites W1988871177 @default.
- W2068467995 cites W1989390298 @default.
- W2068467995 cites W1991655782 @default.
- W2068467995 cites W1993986579 @default.
- W2068467995 cites W2000237058 @default.
- W2068467995 cites W2003676486 @default.
- W2068467995 cites W2013679718 @default.
- W2068467995 cites W2013775923 @default.
- W2068467995 cites W2014742609 @default.
- W2068467995 cites W2014908349 @default.
- W2068467995 cites W2033917233 @default.
- W2068467995 cites W2036645353 @default.
- W2068467995 cites W2043400793 @default.
- W2068467995 cites W2052156572 @default.
- W2068467995 cites W2057185442 @default.
- W2068467995 cites W2059174367 @default.
- W2068467995 cites W2060136185 @default.
- W2068467995 cites W2063311719 @default.
- W2068467995 cites W2066492951 @default.
- W2068467995 cites W2069485016 @default.
- W2068467995 cites W2069767790 @default.
- W2068467995 cites W2070206977 @default.
- W2068467995 cites W2080175437 @default.
- W2068467995 cites W2080671690 @default.
- W2068467995 cites W2083281749 @default.
- W2068467995 cites W2083635994 @default.
- W2068467995 cites W2093624865 @default.
- W2068467995 cites W2100837269 @default.
- W2068467995 cites W2102657200 @default.
- W2068467995 cites W2138645012 @default.
- W2068467995 cites W2169847939 @default.
- W2068467995 cites W2327943268 @default.
- W2068467995 cites W2341167346 @default.
- W2068467995 cites W4252772420 @default.
- W2068467995 doi "https://doi.org/10.1016/0092-8674(85)90076-5" @default.
- W2068467995 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3922627" @default.
- W2068467995 hasPublicationYear "1985" @default.
- W2068467995 type Work @default.
- W2068467995 sameAs 2068467995 @default.
- W2068467995 citedByCount "288" @default.
- W2068467995 countsByYear W20684679952012 @default.
- W2068467995 countsByYear W20684679952013 @default.
- W2068467995 countsByYear W20684679952014 @default.
- W2068467995 countsByYear W20684679952015 @default.
- W2068467995 countsByYear W20684679952016 @default.
- W2068467995 countsByYear W20684679952017 @default.
- W2068467995 countsByYear W20684679952019 @default.
- W2068467995 countsByYear W20684679952020 @default.
- W2068467995 countsByYear W20684679952021 @default.
- W2068467995 countsByYear W20684679952022 @default.
- W2068467995 crossrefType "journal-article" @default.
- W2068467995 hasAuthorship W2068467995A5014396482 @default.
- W2068467995 hasAuthorship W2068467995A5033786344 @default.
- W2068467995 hasAuthorship W2068467995A5062856449 @default.
- W2068467995 hasAuthorship W2068467995A5066185543 @default.
- W2068467995 hasAuthorship W2068467995A5088798867 @default.
- W2068467995 hasAuthorship W2068467995A5088931405 @default.
- W2068467995 hasConcept C105702510 @default.
- W2068467995 hasConcept C12554922 @default.
- W2068467995 hasConcept C14228908 @default.
- W2068467995 hasConcept C142669718 @default.
- W2068467995 hasConcept C142724271 @default.
- W2068467995 hasConcept C1491633281 @default.
- W2068467995 hasConcept C159654299 @default.
- W2068467995 hasConcept C203014093 @default.
- W2068467995 hasConcept C27523624 @default.
- W2068467995 hasConcept C2776735649 @default.
- W2068467995 hasConcept C2777633098 @default.
- W2068467995 hasConcept C2779134260 @default.
- W2068467995 hasConcept C28406088 @default.
- W2068467995 hasConcept C2993140218 @default.
- W2068467995 hasConcept C3019804061 @default.
- W2068467995 hasConcept C55493867 @default.
- W2068467995 hasConcept C59822182 @default.
- W2068467995 hasConcept C71924100 @default.
- W2068467995 hasConcept C78383274 @default.