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- W2068468987 abstract "Tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) are candidate cytokines which are produced by osteoblastic linage cells and promote osteoblast apoptosis, osteoclastogenesis and bone resorption. Here, we examined the effect of (+)-catechin, one of the most common grape flavonols, on osteoblastic MC3T3-E1 cells. (+)-Catechin caused a significant elevation of cell survival at 10−5 and 10−4 M and alkaline phosphatase activity at 10−5 M. Also, treatment with (+)-catechin (10−5 M) decreased bone-resorbing cytokines (TNF-α and IL-6) production and apoptosis in osteoblasts. Our data indicate that the reduction of bone-resorbing cytokines and apoptosis in osteoblasts by (+)-catechin may result in the prevention and therapy for osteoporosis and inflammatory bone diseases." @default.
- W2068468987 created "2016-06-24" @default.
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- W2068468987 date "2003-01-01" @default.
- W2068468987 modified "2023-09-27" @default.
- W2068468987 title "Effects of (+)-Catechin on the Function of Osteoblastic Cells." @default.
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- W2068468987 doi "https://doi.org/10.1248/bpb.26.523" @default.
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