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• W2068470187 abstract "Interest in ultrasound contrast agents (lipid-shelled microbubbles) as delivery vehicles is increasing; however, the biodistribution of these agents remains uncharacterized, both with and without ultrasound. In this study, an 18F-labeled lipid ([18F]fluorodipalmitin), incorporated in microbubble shells, was used as a dynamic microPET probe for quantitative 90-minute biodistribution measurements in male Fischer 344 rats (n = 2). The spleen retained the highest concentration of radioactive lipid at ~ 2.6%-injected dose per cubic centimeter (% ID/cc) and the liver demonstrated the largest total accumulation (~ 17% ID). The microbubble pharmacokinetic profile differed from free lipid, which is rapidly cleared from blood, and liposomes, which remain in circulation. Additionally, region of interest (ROI) analysis over 60 minutes (post-ultrasound treatment) quantified the delivery of lipid by therapeutic ultrasound from microbubbles to kidney tissue (n = 8). The ultrasound sequence consisted of a 200 kPa, 5.3 MHz radiation force pulse followed by a 1.6 MPa, 1.4 MHz fragmentation pulse and was applied to one kidney, while the contralateral kidney served as a control. ROI-estimated activity in treated kidneys was slightly but significantly greater at 0 and 60 min than in untreated kidneys (p = 0.0012 and 0.0035, respectively). This effect increased with the number of microbubbles injected (p = 0.006). In summary, [18F]fluorodipalmitin was used to characterize the biodistribution of contrast microbubble shells and the deposition of lipid was shown to be locally increased after insonation." @default.
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• W2068470187 date "2008-11-01" @default.
• W2068470187 modified "2023-10-02" @default.
• W2068470187 title "Dynamic microPET imaging of ultrasound contrast agents and lipid delivery" @default.
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• W2068470187 doi "https://doi.org/10.1016/j.jconrel.2008.07.030" @default.
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