FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2068474015> ?p ?o ?g. }

• W2068474015 endingPage "4771" @default.
• W2068474015 startingPage "4764" @default.
• W2068474015 abstract "ABSTRACT Cryptococcus neoformans is an opportunistic fungal pathogen that primarily causes disease in immunocompromised individuals. Dendritic cells (DCs) can phagocytose C. neoformans , present cryptococcal antigen, and kill C. neoformans . However, early events following C. neoformans phagocytosis by DCs are not well defined. We hypothesized that C. neoformans traffics to the endosome and the lysosome following phagocytosis by DCs and is eventually killed in the lysosome. Murine bone marrow-derived DCs (BMDCs) or human monocyte-derived DCs (HDCs) were incubated with live, encapsulated C. neoformans yeast cells and opsonizing antibody. Following incubation, DCs were intracellularly stained with antibodies against EEA1 (endosome) and LAMP-1 (late endosome/lysosome). As assessed by confocal microscopy, C. neoformans trafficked to endosomal compartments of DCs within 10 min and to lysosomal compartments within 30 min postincubation. For HDCs, the studies were repeated using complement-sufficient autologous plasma for the opsonization of C. neoformans . These data showed results similar to those for antibody opsonization, with C. neoformans localized to endosomes within 20 min and to lysosomes within 60 min postincubation. Additionally, the results of live real-time imaging studies demonstrated that C. neoformans entered lysosomal compartments within 20 min following the initiation of phagocytosis. The results of scanning and transmission electron microscopy demonstrated conventional zipper phagocytosis of C. neoformans by DCs. Finally, lysosomal extracts were purified from BMDCs and incubated with C. neoformans to determine their potential to kill C. neoformans . The extracts killed C. neoformans in a dose-dependent manner. This study shows that C. neoformans enters into endosomal and lysosomal pathways following DC phagocytosis and can be killed by lysosomal components." @default.
• W2068474015 created "2016-06-24" @default.
• W2068474015 creator A5050851557 @default.
• W2068474015 creator A5054141043 @default.
• W2068474015 date "2008-10-01" @default.
• W2068474015 modified "2023-10-17" @default.
• W2068474015 title "<i>Cryptococcus neoformans</i>Enters the Endolysosomal Pathway of Dendritic Cells and Is Killed by Lysosomal Components" @default.
• W2068474015 cites W1510572236 @default.
• W2068474015 cites W1543518336 @default.
• W2068474015 cites W1553648853 @default.
• W2068474015 cites W1579143707 @default.
• W2068474015 cites W1778644925 @default.
• W2068474015 cites W1872704179 @default.
• W2068474015 cites W1896668130 @default.
• W2068474015 cites W1910190783 @default.
• W2068474015 cites W1912169188 @default.
• W2068474015 cites W1966676434 @default.
• W2068474015 cites W1967920608 @default.
• W2068474015 cites W1977112775 @default.
• W2068474015 cites W1980216821 @default.
• W2068474015 cites W1992994480 @default.
• W2068474015 cites W1996100553 @default.
• W2068474015 cites W2013686234 @default.
• W2068474015 cites W2013829335 @default.
• W2068474015 cites W2021187987 @default.
• W2068474015 cites W2026942254 @default.
• W2068474015 cites W2028673557 @default.
• W2068474015 cites W2048143404 @default.
• W2068474015 cites W2053042611 @default.
• W2068474015 cites W2054301073 @default.
• W2068474015 cites W2055039738 @default.
• W2068474015 cites W2090303095 @default.
• W2068474015 cites W2092235636 @default.
• W2068474015 cites W2093784138 @default.
• W2068474015 cites W2095442519 @default.
• W2068474015 cites W2096323533 @default.
• W2068474015 cites W2096901938 @default.
• W2068474015 cites W2099288361 @default.
• W2068474015 cites W2104043925 @default.
• W2068474015 cites W2105512727 @default.
• W2068474015 cites W2109854599 @default.
• W2068474015 cites W2111220263 @default.
• W2068474015 cites W2111461426 @default.
• W2068474015 cites W2120140056 @default.
• W2068474015 cites W2121449107 @default.
• W2068474015 cites W2121691225 @default.
• W2068474015 cites W2121990753 @default.
• W2068474015 cites W2127782698 @default.
• W2068474015 cites W2128519954 @default.
• W2068474015 cites W2129116472 @default.
• W2068474015 cites W2130941282 @default.
• W2068474015 cites W2131761283 @default.
• W2068474015 cites W2135628211 @default.
• W2068474015 cites W2136817737 @default.
• W2068474015 cites W2140535415 @default.
• W2068474015 cites W2143616661 @default.
• W2068474015 cites W2145742146 @default.
• W2068474015 cites W2147038307 @default.
• W2068474015 cites W2149200346 @default.
• W2068474015 cites W2150547274 @default.
• W2068474015 cites W2159244376 @default.
• W2068474015 cites W2161140777 @default.
• W2068474015 cites W2171123005 @default.
• W2068474015 cites W2171208187 @default.
• W2068474015 cites W2313508921 @default.
• W2068474015 cites W2937686481 @default.
• W2068474015 doi "https://doi.org/10.1128/iai.00660-08" @default.
• W2068474015 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2546838" @default.
• W2068474015 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18678670" @default.
• W2068474015 hasPublicationYear "2008" @default.
• W2068474015 type Work @default.
• W2068474015 sameAs 2068474015 @default.
• W2068474015 citedByCount "73" @default.
• W2068474015 countsByYear W20684740152012 @default.
• W2068474015 countsByYear W20684740152013 @default.
• W2068474015 countsByYear W20684740152014 @default.
• W2068474015 countsByYear W20684740152015 @default.
• W2068474015 countsByYear W20684740152016 @default.
• W2068474015 countsByYear W20684740152017 @default.
• W2068474015 countsByYear W20684740152018 @default.
• W2068474015 countsByYear W20684740152019 @default.
• W2068474015 countsByYear W20684740152020 @default.
• W2068474015 countsByYear W20684740152021 @default.
• W2068474015 countsByYear W20684740152022 @default.
• W2068474015 countsByYear W20684740152023 @default.
• W2068474015 crossrefType "journal-article" @default.
• W2068474015 hasAuthorship W2068474015A5050851557 @default.
• W2068474015 hasAuthorship W2068474015A5054141043 @default.
• W2068474015 hasBestOaLocation W20684740152 @default.
• W2068474015 hasConcept C102747710 @default.
• W2068474015 hasConcept C160448771 @default.
• W2068474015 hasConcept C161478664 @default.
• W2068474015 hasConcept C168507396 @default.
• W2068474015 hasConcept C181199279 @default.
• W2068474015 hasConcept C2777893358 @default.
• W2068474015 hasConcept C2779413141 @default.
• W2068474015 hasConcept C2780216420 @default.
• W2068474015 hasConcept C55493867 @default.

• next