FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2068478727> ?p ?o ?g. }

• W2068478727 endingPage "5248" @default.
• W2068478727 startingPage "5236" @default.
• W2068478727 abstract "Two distinct types of ferritin-like molecules often coexist in bacteria, the heme binding bacterioferritins (Bfr) and the non-heme binding bacterial ferritins (Ftn). The early isolation of a ferritin-like molecule from Pseudomonas aeruginosa suggested the possibility of a bacterioferritin assembled from two different subunits [Moore, G. R., et al. (1994) Biochem. J. 304, 493–497]. Subsequent studies demonstrated the presence of two genes encoding ferritin-like molecules in P. aeruginosa, designated bfrA and bfrB, and suggested that two distinct bacterioferritins may coexist [Ma, J.-F., et al. (1999) J. Bacteriol. 181, 3730–3742]. In this report, we present structural evidence demonstrating that the product of the bfrA gene is a ferritin-like molecule not capable of binding heme that harbors a catalytically active ferroxidase center with structural properties similar to those characteristic of bacterial and archaeal Ftns and clearly distinct from those of the ferroxidase center typical of Bfrs. Consequently, the product of the bfrA gene in P. aeruginosa is a bacterial ferritin, which we propose should be termed Pa FtnA. These results, together with the previous characterization of the product of the bfrB gene as a genuine bacterioferritin (Pa BfrB) [Weeratunga, S. J., et al. (2010) Biochemistry 49, 1160–1175], indicate the coexistence of a bacterial ferritin (Pa FtnA) and a bacterioferritin (Pa BfrB) in P. aeruginosa. In agreement with this idea, we also obtained evidence demonstrating that release of iron from Pa BfrB and Pa FtnA is likely subject to different regulation in P. aerugionsa. Whereas the efficient release of iron stored in Pa FtnA requires only the input of electrons from a ferredoxin NADP reductase (Pa Fpr), the release of iron stored in Pa BfrB requires not only electron delivery by Pa Fpr but also the presence of a “regulator”, the apo form of a bacterioferritin-associated ferredoxin (apo Pa Bfd). Finally, structural analysis of iron uptake in crystallo suggests a possible pathway for the internalization of ferroxidase iron into the interior cavity of Pa FtnA." @default.
• W2068478727 created "2016-06-24" @default.
• W2068478727 creator A5000102260 @default.
• W2068478727 creator A5014977479 @default.
• W2068478727 creator A5022355625 @default.
• W2068478727 creator A5062480406 @default.
• W2068478727 creator A5068294245 @default.
• W2068478727 creator A5078793972 @default.
• W2068478727 creator A5089097694 @default.
• W2068478727 date "2011-05-20" @default.
• W2068478727 modified "2023-09-27" @default.
• W2068478727 title "Two Distinct Ferritin-like Molecules in <i>Pseudomonas aeruginosa</i>: The Product of the <i>bfrA</i> Gene Is a Bacterial Ferritin (FtnA) and Not a Bacterioferritin (Bfr)" @default.
• W2068478727 cites W1495496122 @default.
• W2068478727 cites W1509563342 @default.
• W2068478727 cites W1539796472 @default.
• W2068478727 cites W1581168206 @default.
• W2068478727 cites W1589307419 @default.
• W2068478727 cites W1686689328 @default.
• W2068478727 cites W1882169712 @default.
• W2068478727 cites W1965820790 @default.
• W2068478727 cites W1974527022 @default.
• W2068478727 cites W1978096114 @default.
• W2068478727 cites W1978594401 @default.
• W2068478727 cites W1981366516 @default.
• W2068478727 cites W1988678967 @default.
• W2068478727 cites W1992855765 @default.
• W2068478727 cites W2001055223 @default.
• W2068478727 cites W2004381662 @default.
• W2068478727 cites W2007503375 @default.
• W2068478727 cites W2023062028 @default.
• W2068478727 cites W2033098008 @default.
• W2068478727 cites W2037120894 @default.
• W2068478727 cites W2041382372 @default.
• W2068478727 cites W2041606982 @default.
• W2068478727 cites W2046101665 @default.
• W2068478727 cites W2052555699 @default.
• W2068478727 cites W2064174878 @default.
• W2068478727 cites W2064691604 @default.
• W2068478727 cites W2070019521 @default.
• W2068478727 cites W2072887029 @default.
• W2068478727 cites W2074206586 @default.
• W2068478727 cites W2074986801 @default.
• W2068478727 cites W2075598670 @default.
• W2068478727 cites W2082591298 @default.
• W2068478727 cites W2082795475 @default.
• W2068478727 cites W2094879559 @default.
• W2068478727 cites W2097493124 @default.
• W2068478727 cites W2099888935 @default.
• W2068478727 cites W2106699885 @default.
• W2068478727 cites W2108230904 @default.
• W2068478727 cites W2108816504 @default.
• W2068478727 cites W2110035347 @default.
• W2068478727 cites W2110572977 @default.
• W2068478727 cites W2123651022 @default.
• W2068478727 cites W2124372396 @default.
• W2068478727 cites W2126361514 @default.
• W2068478727 cites W2142585562 @default.
• W2068478727 cites W2149353640 @default.
• W2068478727 cites W2164119014 @default.
• W2068478727 cites W2167079694 @default.
• W2068478727 cites W2312222238 @default.
• W2068478727 cites W2317826237 @default.
• W2068478727 cites W2323630730 @default.
• W2068478727 doi "https://doi.org/10.1021/bi2004119" @default.
• W2068478727 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3130351" @default.
• W2068478727 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21574546" @default.
• W2068478727 hasPublicationYear "2011" @default.
• W2068478727 type Work @default.
• W2068478727 sameAs 2068478727 @default.
• W2068478727 citedByCount "45" @default.
• W2068478727 countsByYear W20684787272012 @default.
• W2068478727 countsByYear W20684787272013 @default.
• W2068478727 countsByYear W20684787272014 @default.
• W2068478727 countsByYear W20684787272015 @default.
• W2068478727 countsByYear W20684787272016 @default.
• W2068478727 countsByYear W20684787272017 @default.
• W2068478727 countsByYear W20684787272018 @default.
• W2068478727 countsByYear W20684787272019 @default.
• W2068478727 countsByYear W20684787272020 @default.
• W2068478727 countsByYear W20684787272021 @default.
• W2068478727 countsByYear W20684787272022 @default.
• W2068478727 countsByYear W20684787272023 @default.
• W2068478727 crossrefType "journal-article" @default.
• W2068478727 hasAuthorship W2068478727A5000102260 @default.
• W2068478727 hasAuthorship W2068478727A5014977479 @default.
• W2068478727 hasAuthorship W2068478727A5022355625 @default.
• W2068478727 hasAuthorship W2068478727A5062480406 @default.
• W2068478727 hasAuthorship W2068478727A5068294245 @default.
• W2068478727 hasAuthorship W2068478727A5078793972 @default.
• W2068478727 hasAuthorship W2068478727A5089097694 @default.
• W2068478727 hasBestOaLocation W20684787272 @default.
• W2068478727 hasConcept C104317684 @default.
• W2068478727 hasConcept C150194340 @default.
• W2068478727 hasConcept C153911025 @default.
• W2068478727 hasConcept C181199279 @default.
• W2068478727 hasConcept C185592680 @default.
• W2068478727 hasConcept C195286587 @default.
• W2068478727 hasConcept C2776217839 @default.

• next