Matches in SemOpenAlex for { <https://semopenalex.org/work/W2068479016> ?p ?o ?g. }
Showing items 1 to 88 of
88
with 100 items per page.
- W2068479016 endingPage "736" @default.
- W2068479016 startingPage "729" @default.
- W2068479016 abstract "The possibility that prostaglandin H2 is an endothelium-derived contracting factor (EDCF) was evaluated in rings of thoracic aorta of spontaneously hypertensive rats (SHR). When the aortic rings were contracted with norepinephrine (10-7mol/l) and treated with acetylcholine (10-5mol/l), a relaxant response with a peak after approximately 1 min and a contractile response with a peak after approximately 7min were observed. When these rings were pretreated with a thromboxane A2/prostaglandin H2 receptor antagonist (ONO-3708), the later contractile response was clearly inhibited and only a sustained relaxant response was observed. This relaxant response was completely inhibited by pretreatment with an inhibitor of nitric oxide production (N-nitroarginine methylester; NNM). When aortic rings in the basal condition were treated with NNM and then with acetylcholine, a contractile response with a peak after 7 min was observed, but this reaction was completely inhibited by pretreatment with ONO-3708. The rate of 6-keto-prostaglandin F1α production showed a peak of 1.4 x 10-6mol/l per min per tissue, 2-4 min after administration of acetylcholine. With exogenous prostaglandin H2 (5 x 10-7mol/l), a peak contraction was observed after approximately 4 min, the degree and pattern of which were similar to that induced by acetylcholine. Endogenous prostaglandin H2 is considered to be produced by the aortic rings in an amount sufficient to induce vascular contraction within 30 s, and the pattern of this contraction induced by acetylcholine resembles that induced by exogenous prostaglandin H2. These findings most strongly suggest that prostaglandin H2 is an EDCF. It is also suggested that, in the rat aorta treated by acetylcholine, the vascular tonus is regulated by two factors, i.e. EDCF (prostaglandin H2) and endothelium-derived relaxing factor (nitric oxide)." @default.
- W2068479016 created "2016-06-24" @default.
- W2068479016 creator A5013772972 @default.
- W2068479016 creator A5016044502 @default.
- W2068479016 creator A5021198996 @default.
- W2068479016 creator A5026541336 @default.
- W2068479016 creator A5064091668 @default.
- W2068479016 creator A5075895632 @default.
- W2068479016 creator A5080730657 @default.
- W2068479016 creator A5087785825 @default.
- W2068479016 creator A5088240663 @default.
- W2068479016 date "1991-08-01" @default.
- W2068479016 modified "2023-10-17" @default.
- W2068479016 title "Prostaglandin H2 as an endothelium-derived contracting factor and its interaction with endothelium-derived nitric oxide" @default.
- W2068479016 doi "https://doi.org/10.1097/00004872-199108000-00006" @default.
- W2068479016 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1655883" @default.
- W2068479016 hasPublicationYear "1991" @default.
- W2068479016 type Work @default.
- W2068479016 sameAs 2068479016 @default.
- W2068479016 citedByCount "74" @default.
- W2068479016 countsByYear W20684790162013 @default.
- W2068479016 countsByYear W20684790162015 @default.
- W2068479016 countsByYear W20684790162016 @default.
- W2068479016 countsByYear W20684790162020 @default.
- W2068479016 crossrefType "journal-article" @default.
- W2068479016 hasAuthorship W2068479016A5013772972 @default.
- W2068479016 hasAuthorship W2068479016A5016044502 @default.
- W2068479016 hasAuthorship W2068479016A5021198996 @default.
- W2068479016 hasAuthorship W2068479016A5026541336 @default.
- W2068479016 hasAuthorship W2068479016A5064091668 @default.
- W2068479016 hasAuthorship W2068479016A5075895632 @default.
- W2068479016 hasAuthorship W2068479016A5080730657 @default.
- W2068479016 hasAuthorship W2068479016A5087785825 @default.
- W2068479016 hasAuthorship W2068479016A5088240663 @default.
- W2068479016 hasConcept C120770815 @default.
- W2068479016 hasConcept C126322002 @default.
- W2068479016 hasConcept C134018914 @default.
- W2068479016 hasConcept C163415756 @default.
- W2068479016 hasConcept C170493617 @default.
- W2068479016 hasConcept C2775910092 @default.
- W2068479016 hasConcept C2776785769 @default.
- W2068479016 hasConcept C2776992346 @default.
- W2068479016 hasConcept C2777198256 @default.
- W2068479016 hasConcept C2780310817 @default.
- W2068479016 hasConcept C2780664492 @default.
- W2068479016 hasConcept C2781024287 @default.
- W2068479016 hasConcept C2781128415 @default.
- W2068479016 hasConcept C519581460 @default.
- W2068479016 hasConcept C71924100 @default.
- W2068479016 hasConcept C89560881 @default.
- W2068479016 hasConceptScore W2068479016C120770815 @default.
- W2068479016 hasConceptScore W2068479016C126322002 @default.
- W2068479016 hasConceptScore W2068479016C134018914 @default.
- W2068479016 hasConceptScore W2068479016C163415756 @default.
- W2068479016 hasConceptScore W2068479016C170493617 @default.
- W2068479016 hasConceptScore W2068479016C2775910092 @default.
- W2068479016 hasConceptScore W2068479016C2776785769 @default.
- W2068479016 hasConceptScore W2068479016C2776992346 @default.
- W2068479016 hasConceptScore W2068479016C2777198256 @default.
- W2068479016 hasConceptScore W2068479016C2780310817 @default.
- W2068479016 hasConceptScore W2068479016C2780664492 @default.
- W2068479016 hasConceptScore W2068479016C2781024287 @default.
- W2068479016 hasConceptScore W2068479016C2781128415 @default.
- W2068479016 hasConceptScore W2068479016C519581460 @default.
- W2068479016 hasConceptScore W2068479016C71924100 @default.
- W2068479016 hasConceptScore W2068479016C89560881 @default.
- W2068479016 hasIssue "8" @default.
- W2068479016 hasLocation W20684790161 @default.
- W2068479016 hasLocation W20684790162 @default.
- W2068479016 hasOpenAccess W2068479016 @default.
- W2068479016 hasPrimaryLocation W20684790161 @default.
- W2068479016 hasRelatedWork W1015582436 @default.
- W2068479016 hasRelatedWork W1967552042 @default.
- W2068479016 hasRelatedWork W2030904049 @default.
- W2068479016 hasRelatedWork W2071788168 @default.
- W2068479016 hasRelatedWork W2127203967 @default.
- W2068479016 hasRelatedWork W2164007258 @default.
- W2068479016 hasRelatedWork W2317586421 @default.
- W2068479016 hasRelatedWork W2409473283 @default.
- W2068479016 hasRelatedWork W2438402603 @default.
- W2068479016 hasRelatedWork W7045721 @default.
- W2068479016 hasVolume "9" @default.
- W2068479016 isParatext "false" @default.
- W2068479016 isRetracted "false" @default.
- W2068479016 magId "2068479016" @default.
- W2068479016 workType "article" @default.