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• W2068487066 abstract "Zolmitriptan is a selective 5-HT1B/1D receptor agonist for acute oral imgraine theraphy. This randomized, placebo|controlled, parallel-grup study investigated the efficacy and tolerability of oral zolmitriptan (5, 10, 15 and 20 mg) in the tretment of single acute migraine attacks. Of 1181 patients randomized, 840 were evaluable for the primary efficacy analysis. Headache response rates (a reduction in headache intensity from severe or moderate at baseline to mild or no pain at 2 hours post-treatment) were similaracross the zolmitriptan dose groups (66%, 71%, 69% and 77% for 5 mg, 10 mg, 15 mg and 20 mg, respectively) and were significantly higher than that for placebo (19%; all groups P < 0.001). A headache response was reponse was reposted at 1 hour by 40-50% of zolmitriptan recipients (16% placebo). At 2 hours post dose,39-47% of zolmitriptan-treated patients were pain-free, compared with 1% of placebo recipients. Headache recurrence occurred in 21-29% (upper 95% CI 37.1) of zolmitriptan-treated patients and in 65% (95% CI 38.3, 85.8) of placebo recipients. Zolmitriptan was well tolerated at each dose. The most commonly reported adverse events were asthenia, dizziness, paraesthesia and feelings of heaviness. Mostadverse events were of mildor moderate intensity and were efficacy and tolerability profile, the dose response data suggest that lower doses would also offer significant efficacy." @default.
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• W2068487066 date "1998-11-01" @default.
• W2068487066 modified "2023-10-16" @default.
• W2068487066 title "Zolmitriptan, a 5-HT1B/1D receptor agonist for the acute oral treatment of migraine: a multicentre, dose-range finding study" @default.
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• W2068487066 doi "https://doi.org/10.1046/j.1468-1331.1998.560535.x" @default.
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