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- W2068487145 abstract "Abstract Hemolysis by NDV was preceded by a rapid release of potassium from the cells and by cell swelling. The potassium release reflected an increased cation permeability of the cell due to the action of the virus. This caused an over-all rise in the internal ionic concentration and osmotic pressure due to the influx of ions from the medium, and led to cell swelling and lysis. Antiserum abolished the reaction of the virus with the cell. Hemolysis was inhibited also by substances that prevented cell swelling but did not affect the initial action of the virus. Cell swelling and hemolysis were reversibly inhibited by albumin, which raised the external osmotic pressure, and by calcium, which probably reduced the cation permeability of the cells. Phloridzin inhibited hemolysis irreversibly by diminishing cell swelling in an unexplained manner. Hemolytic viruses also released potassium and protein from HeLa cells and ascites tumor cells. No detectable release of potassium occurred in the presence of other viruses that are known to infect these cells. The release of large amounts of potassium is therefore due to the hemolytic action of a virus and is not associated with the initiation of infection." @default.
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- W2068487145 date "1960-12-01" @default.
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- W2068487145 title "Hemolysis and the release of potassium from cells by Newcastle disease virus (NDV)" @default.
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- W2068487145 doi "https://doi.org/10.1016/0042-6822(60)90177-x" @default.
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