Matches in SemOpenAlex for { <https://semopenalex.org/work/W2068488512> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W2068488512 endingPage "117" @default.
- W2068488512 startingPage "115" @default.
- W2068488512 abstract "Alzheimer's disease (AD) is the most common cause of dementia in Western countries and in Japan. Early diagnosis and treatment is needed to slow down the degenerative process and dementia in AD. The main histopathological characteristics of AD are senile plaques and neurofibrillary tangles. Based on the disease pathology, numerous blood and cerebrospinal fluid (CSF) tests have been proposed for early detection of AD. However, there is no definite clinical method to determine in which patients with mild cognitive impairment will progress to AD with dementia. Since pigment epithelium-derived factor (PEDF) has been recently shown to protect various types of cells including neuronal cells against oxidative stress- or glutamate-induced injury through its anti-oxidative properties, we examined here the expression levels of PEDF in AD's brain. PEDF was found to have the strong immunoreactivity in cortical neurons and astrocytes in the brains of AD. Further, the distribution of PEDF proteins was good concordance with RAGE proteins, one of the receptors for amyloid β peptides, which are involved in neuronal cell death and microglial activation in AD. These results suggest that PEDF overexpression may indicate a compensation mechanism to fight against neuronal cell injury in AD. Our present observations suggest that PEDF in CSF might reflect cerebral PEDF turnover and provide a means for monitoring neuronal perturbation induced by oxidative stress in the early stage of AD. Clinical use of CSF-PEDF as a biomarker for AD might enable more effective diagnosis and treatment of patients with this disorder." @default.
- W2068488512 created "2016-06-24" @default.
- W2068488512 creator A5007171653 @default.
- W2068488512 creator A5015715722 @default.
- W2068488512 creator A5030113532 @default.
- W2068488512 creator A5037787862 @default.
- W2068488512 date "2004-01-01" @default.
- W2068488512 modified "2023-09-25" @default.
- W2068488512 title "Is pigment epithelium-derived factor level in cerebrospinal fluid a promising biomarker for early diagnosis of Alzheimer's disease?" @default.
- W2068488512 cites W1970130998 @default.
- W2068488512 cites W1993505705 @default.
- W2068488512 cites W2008050572 @default.
- W2068488512 cites W2014199968 @default.
- W2068488512 cites W2014280596 @default.
- W2068488512 cites W2049167261 @default.
- W2068488512 cites W2075701227 @default.
- W2068488512 cites W2083284128 @default.
- W2068488512 cites W2087347988 @default.
- W2068488512 cites W2113044359 @default.
- W2068488512 cites W2117690477 @default.
- W2068488512 cites W2118836695 @default.
- W2068488512 cites W2162059739 @default.
- W2068488512 cites W2164139107 @default.
- W2068488512 doi "https://doi.org/10.1016/j.mehy.2004.02.022" @default.
- W2068488512 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15193361" @default.
- W2068488512 hasPublicationYear "2004" @default.
- W2068488512 type Work @default.
- W2068488512 sameAs 2068488512 @default.
- W2068488512 citedByCount "27" @default.
- W2068488512 countsByYear W20684885122012 @default.
- W2068488512 countsByYear W20684885122014 @default.
- W2068488512 countsByYear W20684885122015 @default.
- W2068488512 countsByYear W20684885122016 @default.
- W2068488512 countsByYear W20684885122017 @default.
- W2068488512 countsByYear W20684885122018 @default.
- W2068488512 countsByYear W20684885122019 @default.
- W2068488512 countsByYear W20684885122021 @default.
- W2068488512 countsByYear W20684885122022 @default.
- W2068488512 crossrefType "journal-article" @default.
- W2068488512 hasAuthorship W2068488512A5007171653 @default.
- W2068488512 hasAuthorship W2068488512A5015715722 @default.
- W2068488512 hasAuthorship W2068488512A5030113532 @default.
- W2068488512 hasAuthorship W2068488512A5037787862 @default.
- W2068488512 hasConcept C126322002 @default.
- W2068488512 hasConcept C142724271 @default.
- W2068488512 hasConcept C167734588 @default.
- W2068488512 hasConcept C169760540 @default.
- W2068488512 hasConcept C2776151105 @default.
- W2068488512 hasConcept C2779134260 @default.
- W2068488512 hasConcept C2779483572 @default.
- W2068488512 hasConcept C2779651940 @default.
- W2068488512 hasConcept C2781197716 @default.
- W2068488512 hasConcept C502032728 @default.
- W2068488512 hasConcept C52237779 @default.
- W2068488512 hasConcept C55493867 @default.
- W2068488512 hasConcept C68026918 @default.
- W2068488512 hasConcept C71924100 @default.
- W2068488512 hasConcept C86803240 @default.
- W2068488512 hasConceptScore W2068488512C126322002 @default.
- W2068488512 hasConceptScore W2068488512C142724271 @default.
- W2068488512 hasConceptScore W2068488512C167734588 @default.
- W2068488512 hasConceptScore W2068488512C169760540 @default.
- W2068488512 hasConceptScore W2068488512C2776151105 @default.
- W2068488512 hasConceptScore W2068488512C2779134260 @default.
- W2068488512 hasConceptScore W2068488512C2779483572 @default.
- W2068488512 hasConceptScore W2068488512C2779651940 @default.
- W2068488512 hasConceptScore W2068488512C2781197716 @default.
- W2068488512 hasConceptScore W2068488512C502032728 @default.
- W2068488512 hasConceptScore W2068488512C52237779 @default.
- W2068488512 hasConceptScore W2068488512C55493867 @default.
- W2068488512 hasConceptScore W2068488512C68026918 @default.
- W2068488512 hasConceptScore W2068488512C71924100 @default.
- W2068488512 hasConceptScore W2068488512C86803240 @default.
- W2068488512 hasFunder F4320309791 @default.
- W2068488512 hasFunder F4320320912 @default.
- W2068488512 hasFunder F4320322203 @default.
- W2068488512 hasIssue "1" @default.
- W2068488512 hasLocation W20684885121 @default.
- W2068488512 hasLocation W20684885122 @default.
- W2068488512 hasOpenAccess W2068488512 @default.
- W2068488512 hasPrimaryLocation W20684885121 @default.
- W2068488512 hasRelatedWork W2062489139 @default.
- W2068488512 hasRelatedWork W2079472057 @default.
- W2068488512 hasRelatedWork W2083984027 @default.
- W2068488512 hasRelatedWork W2106003388 @default.
- W2068488512 hasRelatedWork W2128540699 @default.
- W2068488512 hasRelatedWork W2133638306 @default.
- W2068488512 hasRelatedWork W2347357864 @default.
- W2068488512 hasRelatedWork W2386985152 @default.
- W2068488512 hasRelatedWork W2804922289 @default.
- W2068488512 hasRelatedWork W313460363 @default.
- W2068488512 hasVolume "63" @default.
- W2068488512 isParatext "false" @default.
- W2068488512 isRetracted "false" @default.
- W2068488512 magId "2068488512" @default.
- W2068488512 workType "article" @default.