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- W2068493918 abstract "Interleukin-1 beta converting enzyme is the first member of a new class of cysteine proteases. The most distinguishing feature of this family is a nearly absolute specificity for cleavage at aspartic acid. This enzyme has been the subject of intense research because of its role in the production of IL-1 beta, a key mediator of inflammation. These studies have culminated in the design of potent inhibitors and determination of its crystal structure. The structure secures the relationship of the enzyme to CED-3, the product of a gene required for programmed cell death in Caenorhabditis elegans, suggesting that members of this family function in cell death in vertebrates." @default.
- W2068493918 created "2016-06-24" @default.
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- W2068493918 creator A5023276523 @default.
- W2068493918 date "1995-01-01" @default.
- W2068493918 modified "2023-10-17" @default.
- W2068493918 title "Interleukin-1<i>β</i>converting enzyme: A novel cysteine protease required for IL-1<i>β</i>production and implicated in programmed cell death" @default.
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- W2068493918 doi "https://doi.org/10.1002/pro.5560040102" @default.
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