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- W2068495491 abstract "Obstructive sleep apnea (OSA) is characterized by recurrent obstruction of the pharyngeal airway during sleep, and results in episodes of intermittent hypoxia. Regardless of the presence of daytime symptoms, OSA is an independent risk factor for cardiovascular disease and increased mortality.1 A number of studies have shown that development of OSA correlates with increasing weight. The prevalence of OSA among obese patients has been reported, and substantial improvement was achieved by weight reduction.2 Regarding the pathophysiology of OSA, an anatomically small pharyngeal airway is a prerequisite factor leading to OSA. This smaller airway size always worsens with increasing body fat and obesity.3 When luminal size is narrower, it makes the airway vulnerable to collapse. An individual with OSA is able to compensate for this modified anatomy by increasing the activity of the upper airway muscles during the time that he or she is awake. However, with the onset of sleep, this compensation is lost and airway obstruction occurs. Even short periods of apnea can induce a rise in PaCO2, a fall in PaO2, and increased ventilatory effort against an occluded airway. Therefore, patients with OSA experience repetitive episodes of hypoxia during transient cessation of breathing that promote inflammation and oxidative stress. In addition to direct fat deposits within the airway walls, the upper airway size may be smaller in obese patients because of a reduced lung volume.3" @default.
- W2068495491 created "2016-06-24" @default.
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- W2068495491 date "2010-05-07" @default.
- W2068495491 modified "2023-10-12" @default.
- W2068495491 title "Not sleeping well can damage your heart" @default.
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- W2068495491 doi "https://doi.org/10.1038/hr.2010.53" @default.
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