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- W2068499899 abstract "Background: Direct-infusion ESI–MS/MS is a powerful approach for the identification of substances in complex mixtures. The aim of this work was to investigate its applicability to the toxicological screening of blood samples. A simple protein precipitation was used, followed by a 15 min infusion of the extract in the mass spectrometer. Results: The application of the procedure to commercial quality controls and authentic post-mortem blood samples demonstrated that the direct-infusion ESI–MS/MS approach enables the simultaneous identification of substances that require different chromatographic conditions. However, poor sensitivity was observed for benzodiazepine, amphetamines and opiate compounds. Conclusion: Considering the facile implementation and positive performance of direct-infusion ESI–MS/MS, this approach may to be a valuable complementary technique for systematic toxicological analysis procedures." @default.
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- W2068499899 date "2014-08-01" @default.
- W2068499899 modified "2023-09-23" @default.
- W2068499899 title "Application of direct-infusion ESI–MS/MS for toxicological screening" @default.
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- W2068499899 doi "https://doi.org/10.4155/bio.14.58" @default.
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