FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2068500082> ?p ?o ?g. }

• W2068500082 endingPage "e34140" @default.
• W2068500082 startingPage "e34140" @default.
• W2068500082 abstract "Virus host evasion genes are ready-made tools for gene manipulation and therapy. In this work we have assessed the impact in vivo of the evasion gene A238L of the African Swine Fever Virus, a gene which inhibits transcription mediated by both NF-κB and NFAT. The A238L gene has been selectively expressed in mouse T lymphocytes using tissue specific promoter, enhancer and locus control region sequences for CD2. The resulting two independently derived transgenic mice expressed the transgene and developed a metastasic, angiogenic and transplantable CD4(+)CD8(+)CD69(-) lymphoma. The CD4(+)CD8(+)CD69(-) cells also grew vigorously in vitro. The absence of CD69 from the tumour cells suggests that they were derived from T cells at a stage prior to positive selection. In contrast, transgenic mice similarly expressing a mutant A238L, solely inhibiting transcription mediated by NF-κB, were indistinguishable from wild type mice. Expression of Rag1, Rag2, TCRβ-V8.2, CD25, FoxP3, Bcl3, Bcl2 l14, Myc, IL-2, NFAT1 and Itk, by purified CD4(+)CD8(+)CD69(-) thymocytes from A238L transgenic mice was consistent with the phenotype. Similarly evaluated expression profiles of CD4(+)CD8(+) CD69(-) thymocytes from the mutant A238L transgenic mice were comparable to those of wild type mice. These features, together with the demonstration of (mono-)oligoclonality, suggest a transgene-NFAT-dependent transformation yielding a lymphoma with a phenotype reminiscent of some acute lymphoblastic lymphomas." @default.
• W2068500082 created "2016-06-24" @default.
• W2068500082 creator A5001593820 @default.
• W2068500082 creator A5017992259 @default.
• W2068500082 creator A5042730627 @default.
• W2068500082 creator A5079785844 @default.
• W2068500082 creator A5082924725 @default.
• W2068500082 date "2012-04-27" @default.
• W2068500082 modified "2023-10-14" @default.
• W2068500082 title "Neoplastic Transformation of T Lymphocytes through Transgenic Expression of a Virus Host Modification Protein" @default.
• W2068500082 cites W1491531822 @default.
• W2068500082 cites W1898244903 @default.
• W2068500082 cites W1938389250 @default.
• W2068500082 cites W1949250048 @default.
• W2068500082 cites W1976257926 @default.
• W2068500082 cites W1978791876 @default.
• W2068500082 cites W1982062664 @default.
• W2068500082 cites W1984975924 @default.
• W2068500082 cites W1987684167 @default.
• W2068500082 cites W2002075569 @default.
• W2068500082 cites W2006233454 @default.
• W2068500082 cites W2013874066 @default.
• W2068500082 cites W2017823454 @default.
• W2068500082 cites W2018718597 @default.
• W2068500082 cites W2020464368 @default.
• W2068500082 cites W2020955202 @default.
• W2068500082 cites W2027767232 @default.
• W2068500082 cites W2033810895 @default.
• W2068500082 cites W2035616122 @default.
• W2068500082 cites W2038134959 @default.
• W2068500082 cites W2038538882 @default.
• W2068500082 cites W2040470926 @default.
• W2068500082 cites W2040792935 @default.
• W2068500082 cites W2050126429 @default.
• W2068500082 cites W2051782982 @default.
• W2068500082 cites W2051974385 @default.
• W2068500082 cites W2057837626 @default.
• W2068500082 cites W2063275245 @default.
• W2068500082 cites W2066270106 @default.
• W2068500082 cites W2067973732 @default.
• W2068500082 cites W2069426612 @default.
• W2068500082 cites W2086008721 @default.
• W2068500082 cites W2091094420 @default.
• W2068500082 cites W2091365240 @default.
• W2068500082 cites W2096589599 @default.
• W2068500082 cites W2101431783 @default.
• W2068500082 cites W2116325546 @default.
• W2068500082 cites W2123898551 @default.
• W2068500082 cites W2124371255 @default.
• W2068500082 cites W2130079626 @default.
• W2068500082 cites W2144084857 @default.
• W2068500082 cites W2152676546 @default.
• W2068500082 cites W2161113731 @default.
• W2068500082 cites W2166011088 @default.
• W2068500082 cites W2168513984 @default.
• W2068500082 cites W64744690 @default.
• W2068500082 doi "https://doi.org/10.1371/journal.pone.0034140" @default.
• W2068500082 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3338727" @default.
• W2068500082 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22558084" @default.
• W2068500082 hasPublicationYear "2012" @default.
• W2068500082 type Work @default.
• W2068500082 sameAs 2068500082 @default.
• W2068500082 citedByCount "3" @default.
• W2068500082 countsByYear W20685000822013 @default.
• W2068500082 countsByYear W20685000822015 @default.
• W2068500082 countsByYear W20685000822021 @default.
• W2068500082 crossrefType "journal-article" @default.
• W2068500082 hasAuthorship W2068500082A5001593820 @default.
• W2068500082 hasAuthorship W2068500082A5017992259 @default.
• W2068500082 hasAuthorship W2068500082A5042730627 @default.
• W2068500082 hasAuthorship W2068500082A5079785844 @default.
• W2068500082 hasAuthorship W2068500082A5082924725 @default.
• W2068500082 hasBestOaLocation W20685000821 @default.
• W2068500082 hasConcept C102230213 @default.
• W2068500082 hasConcept C104317684 @default.
• W2068500082 hasConcept C111936080 @default.
• W2068500082 hasConcept C150194340 @default.
• W2068500082 hasConcept C153911025 @default.
• W2068500082 hasConcept C159047783 @default.
• W2068500082 hasConcept C167672396 @default.
• W2068500082 hasConcept C176324957 @default.
• W2068500082 hasConcept C189938988 @default.
• W2068500082 hasConcept C203014093 @default.
• W2068500082 hasConcept C2776090121 @default.
• W2068500082 hasConcept C54355233 @default.
• W2068500082 hasConcept C79484868 @default.
• W2068500082 hasConcept C86339819 @default.
• W2068500082 hasConcept C86803240 @default.
• W2068500082 hasConcept C8891405 @default.
• W2068500082 hasConceptScore W2068500082C102230213 @default.
• W2068500082 hasConceptScore W2068500082C104317684 @default.
• W2068500082 hasConceptScore W2068500082C111936080 @default.
• W2068500082 hasConceptScore W2068500082C150194340 @default.
• W2068500082 hasConceptScore W2068500082C153911025 @default.
• W2068500082 hasConceptScore W2068500082C159047783 @default.
• W2068500082 hasConceptScore W2068500082C167672396 @default.
• W2068500082 hasConceptScore W2068500082C176324957 @default.
• W2068500082 hasConceptScore W2068500082C189938988 @default.

• next