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- W2068504303 abstract "The effect of MK-401 (4-amino-6-trichloroethenyl 1,3-benzenedisulfonamide) on Fasciola hepatica phosphoglycerate kinase (EC 2.7.2.3) was investigated. MK-401 was a competitive inhibitor of both 3-phosphoglycerate and ATP and had a Ki of 0.29 mM. ATP, 1,3-diphosphoglycerate and MK-401 protected the Fasciola enzyme from inhibition by N-ethylmaleimide. Analogues of MK-401 with different substituents at the 6 position (R = Cl, CF3, C2 F3, C3 F7) were competitive inhibitors of both 3-phosphoglycerate and ATP and a good correlation between the Ki and in vivo activity of these analogues was observed." @default.
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- W2068504303 date "1982-03-01" @default.
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- W2068504303 title "Mechanism of action of MK-401 against Fasciola hepatica: Inhibition of phosphoglycerate kinase" @default.
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- W2068504303 doi "https://doi.org/10.1016/0166-6851(82)90016-0" @default.
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