Matches in SemOpenAlex for { <https://semopenalex.org/work/W2068504993> ?p ?o ?g. }
- W2068504993 endingPage "1160" @default.
- W2068504993 startingPage "1155" @default.
- W2068504993 abstract "A wealth of evidence indicates that the activation of 5-HT 1A and 5-HT 2A receptors in the dorsal periaqueductal grey matter (dPAG) inhibits escape, a panic-related defensive behaviour. Results that were previously obtained with the elevated T-maze test of anxiety/panic suggest that 5-HT 1A and μ-opioid receptors in this midbrain area work together to regulate this response. To investigate the generality of this finding, we assessed whether the same cooperative mechanism is engaged when escape is evoked by a different aversive stimulus electrical stimulation of the dPAG. Administration of the μ-receptor blocker CTOP into the dPAG did not change the escape threshold, but microinjection of the μ-receptor agonist DAMGO (0.3 and 0.5 nmol) or the 5-HT 1A receptor agonist 8-OHDPAT (1.6 nmol) increased this index, indicating a panicolytic-like effect. Pretreatment with CTOP antagonised the anti-escape effect of 8-OHDPAT. Additionally, combined administration of subeffective doses of DAMGO and 8-OHDPAT increased the escape threshold, indicating drug synergism. Therefore, regardless of the aversive nature of the stimulus, μ-opioid and 5-HT 1A receptors cooperatively act to regulate escape behaviour. A better comprehension of this mechanism might allow for new therapeutic strategies for panic disorder." @default.
- W2068504993 created "2016-06-24" @default.
- W2068504993 creator A5040514441 @default.
- W2068504993 creator A5041631838 @default.
- W2068504993 creator A5051139254 @default.
- W2068504993 creator A5063297653 @default.
- W2068504993 creator A5074011773 @default.
- W2068504993 date "2014-10-14" @default.
- W2068504993 modified "2023-10-16" @default.
- W2068504993 title "Interaction between μ-opioid and 5-HT<sub>1A</sub> receptors in the regulation of panic-related defensive responses in the rat dorsal periaqueductal grey" @default.
- W2068504993 cites W1966889241 @default.
- W2068504993 cites W1973271844 @default.
- W2068504993 cites W1974609970 @default.
- W2068504993 cites W1992488144 @default.
- W2068504993 cites W1995424791 @default.
- W2068504993 cites W2003857433 @default.
- W2068504993 cites W2026645313 @default.
- W2068504993 cites W2030802293 @default.
- W2068504993 cites W2042520607 @default.
- W2068504993 cites W2046281644 @default.
- W2068504993 cites W2053877467 @default.
- W2068504993 cites W2056575770 @default.
- W2068504993 cites W2088945268 @default.
- W2068504993 cites W2092261887 @default.
- W2068504993 cites W2113492809 @default.
- W2068504993 cites W2155667685 @default.
- W2068504993 doi "https://doi.org/10.1177/0269881114554274" @default.
- W2068504993 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25315826" @default.
- W2068504993 hasPublicationYear "2014" @default.
- W2068504993 type Work @default.
- W2068504993 sameAs 2068504993 @default.
- W2068504993 citedByCount "19" @default.
- W2068504993 countsByYear W20685049932015 @default.
- W2068504993 countsByYear W20685049932016 @default.
- W2068504993 countsByYear W20685049932017 @default.
- W2068504993 countsByYear W20685049932018 @default.
- W2068504993 countsByYear W20685049932019 @default.
- W2068504993 countsByYear W20685049932020 @default.
- W2068504993 countsByYear W20685049932022 @default.
- W2068504993 countsByYear W20685049932023 @default.
- W2068504993 crossrefType "journal-article" @default.
- W2068504993 hasAuthorship W2068504993A5040514441 @default.
- W2068504993 hasAuthorship W2068504993A5041631838 @default.
- W2068504993 hasAuthorship W2068504993A5051139254 @default.
- W2068504993 hasAuthorship W2068504993A5063297653 @default.
- W2068504993 hasAuthorship W2068504993A5074011773 @default.
- W2068504993 hasConcept C118552586 @default.
- W2068504993 hasConcept C126322002 @default.
- W2068504993 hasConcept C15744967 @default.
- W2068504993 hasConcept C169760540 @default.
- W2068504993 hasConcept C170493617 @default.
- W2068504993 hasConcept C2776401185 @default.
- W2068504993 hasConcept C2778938600 @default.
- W2068504993 hasConcept C2779886867 @default.
- W2068504993 hasConcept C2780712732 @default.
- W2068504993 hasConcept C2781063702 @default.
- W2068504993 hasConcept C2781069035 @default.
- W2068504993 hasConcept C529278444 @default.
- W2068504993 hasConcept C552161191 @default.
- W2068504993 hasConcept C558461103 @default.
- W2068504993 hasConcept C71924100 @default.
- W2068504993 hasConcept C81077568 @default.
- W2068504993 hasConcept C98274493 @default.
- W2068504993 hasConceptScore W2068504993C118552586 @default.
- W2068504993 hasConceptScore W2068504993C126322002 @default.
- W2068504993 hasConceptScore W2068504993C15744967 @default.
- W2068504993 hasConceptScore W2068504993C169760540 @default.
- W2068504993 hasConceptScore W2068504993C170493617 @default.
- W2068504993 hasConceptScore W2068504993C2776401185 @default.
- W2068504993 hasConceptScore W2068504993C2778938600 @default.
- W2068504993 hasConceptScore W2068504993C2779886867 @default.
- W2068504993 hasConceptScore W2068504993C2780712732 @default.
- W2068504993 hasConceptScore W2068504993C2781063702 @default.
- W2068504993 hasConceptScore W2068504993C2781069035 @default.
- W2068504993 hasConceptScore W2068504993C529278444 @default.
- W2068504993 hasConceptScore W2068504993C552161191 @default.
- W2068504993 hasConceptScore W2068504993C558461103 @default.
- W2068504993 hasConceptScore W2068504993C71924100 @default.
- W2068504993 hasConceptScore W2068504993C81077568 @default.
- W2068504993 hasConceptScore W2068504993C98274493 @default.
- W2068504993 hasIssue "12" @default.
- W2068504993 hasLocation W20685049931 @default.
- W2068504993 hasLocation W20685049932 @default.
- W2068504993 hasOpenAccess W2068504993 @default.
- W2068504993 hasPrimaryLocation W20685049931 @default.
- W2068504993 hasRelatedWork W129369426 @default.
- W2068504993 hasRelatedWork W1967318820 @default.
- W2068504993 hasRelatedWork W2179304656 @default.
- W2068504993 hasRelatedWork W2246921844 @default.
- W2068504993 hasRelatedWork W2374436524 @default.
- W2068504993 hasRelatedWork W2396476159 @default.
- W2068504993 hasRelatedWork W2409757104 @default.
- W2068504993 hasRelatedWork W3029404345 @default.
- W2068504993 hasRelatedWork W4231990708 @default.
- W2068504993 hasRelatedWork W98573782 @default.
- W2068504993 hasVolume "28" @default.
- W2068504993 isParatext "false" @default.
- W2068504993 isRetracted "false" @default.