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• W2068507850 abstract "The constitutive and inducible expression of aryl hydrocarbon receptor (AhR) and of the AhR-regulated genes coding for CYP1A1, CYP1A2, CYP1B1, CYP2S1, and Nrf2 was investigated by real-time or traditional PCR in cerebral areas (cortex, cerebellum, midbrain, and hippocampus), blood-brain interfaces (meninges and brain microvessels) and liver obtained from control pigs and from pigs treated with beta-naphthoflavone (betaNF), a potent AhR agonist. The enzymatic activities of ethoxyresorufin-O-deethylase (EROD), and methoxyresorufin-O-deethylase (MEROD), marker for CYP1A1 and CYP1A2, the GST and various antioxidant enzymes (catalase, superoxide dismutase, GSSG-reductase, and GSH-peroxidase) were also determined in the same CNS regions. The AhR, CYP1A1, CYP1A2, CYP1B1, Nrf2 mRNAs were detected, although at different extent, in all the CNS regions, while CYP2S1 mRNA was detected only in midbrain. In the blood-brain interfaces, the constitutive basal expression of AhR and CYP1A1 was comparable to the hepatic one and even higher for CYP1B1 and Nrf2. The treatment with betaNF determined the induction of CYP1A1 and 1B1 (but not of AhR, CYP1A2, and Nrf2) mRNA levels in various CNS areas; notably, CYP1A1 mRNA was increased to about 300-fold in the microvessels. The analysis of enzymatic activities revealed that EROD, but not MEROD, was induced in microsomes but not in mitochondria of all the CNS areas. However, the mitochondrial EROD activities were comparable (in midbrain, meninges) or higher (in cortex, cerebellum, hippocampus) than the microsomal ones, suggesting an important metabolic function of CYP1A1 in this subcellular localization. The activities of GST and antioxidant enzymes were detected in all CNS tissues, with levels lower than the hepatic ones, but found quite evenly distributed and marginally affected by betaNF treatment. The high expression of metabolic enzymes found in blood-brain interfaces could represent a very important defence toward toxins of CNS." @default.
• W2068507850 created "2016-06-24" @default.
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• W2068507850 date "2009-11-01" @default.
• W2068507850 modified "2023-10-17" @default.
• W2068507850 title "Effect of β-naphthoflavone on AhR-regulated genes (CYP1A1, 1A2, 1B1, 2S1, Nrf2, and GST) and antioxidant enzymes in various brain regions of pig" @default.
• W2068507850 cites W1532212858 @default.
• W2068507850 cites W1546592314 @default.
• W2068507850 cites W1581414347 @default.
• W2068507850 cites W162061720 @default.
• W2068507850 cites W1963519745 @default.
• W2068507850 cites W1964109666 @default.
• W2068507850 cites W1967464752 @default.
• W2068507850 cites W1968906511 @default.
• W2068507850 cites W1979036491 @default.
• W2068507850 cites W1981032142 @default.
• W2068507850 cites W1982671427 @default.
• W2068507850 cites W1986099314 @default.
• W2068507850 cites W1991265255 @default.
• W2068507850 cites W1994287101 @default.
• W2068507850 cites W1996143925 @default.
• W2068507850 cites W2005585150 @default.
• W2068507850 cites W2006311748 @default.
• W2068507850 cites W2009142459 @default.
• W2068507850 cites W2017891661 @default.
• W2068507850 cites W2021275669 @default.
• W2068507850 cites W2028043138 @default.
• W2068507850 cites W2029860961 @default.
• W2068507850 cites W2034889832 @default.
• W2068507850 cites W2040222743 @default.
• W2068507850 cites W2040728312 @default.
• W2068507850 cites W2047499088 @default.
• W2068507850 cites W2055929484 @default.
• W2068507850 cites W2056755823 @default.
• W2068507850 cites W2063092399 @default.
• W2068507850 cites W2063319889 @default.
• W2068507850 cites W2065054472 @default.
• W2068507850 cites W2065423133 @default.
• W2068507850 cites W2069230352 @default.
• W2068507850 cites W2071986727 @default.
• W2068507850 cites W2076653387 @default.
• W2068507850 cites W2076738082 @default.
• W2068507850 cites W2076821709 @default.
• W2068507850 cites W2079681465 @default.
• W2068507850 cites W2079808944 @default.
• W2068507850 cites W2080689274 @default.
• W2068507850 cites W2082048404 @default.
• W2068507850 cites W2082894824 @default.
• W2068507850 cites W2084018131 @default.
• W2068507850 cites W2084200591 @default.
• W2068507850 cites W2084949885 @default.
• W2068507850 cites W2088866343 @default.
• W2068507850 cites W2092905174 @default.
• W2068507850 cites W2094391811 @default.
• W2068507850 cites W2094695063 @default.
• W2068507850 cites W2097545237 @default.
• W2068507850 cites W2099144033 @default.
• W2068507850 cites W2110549334 @default.
• W2068507850 cites W2113672678 @default.
• W2068507850 cites W2117530523 @default.
• W2068507850 cites W2126131484 @default.
• W2068507850 cites W2132006762 @default.
• W2068507850 cites W2139286576 @default.
• W2068507850 cites W2143843699 @default.
• W2068507850 cites W2161338166 @default.
• W2068507850 cites W2166400638 @default.
• W2068507850 cites W2169573748 @default.
• W2068507850 cites W4243239484 @default.
• W2068507850 cites W4376634175 @default.
• W2068507850 doi "https://doi.org/10.1016/j.tox.2009.09.010" @default.
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