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- W2068511052 abstract "SummaryImmune cytotoxicity of herpesvirus-infected cells was studied by means of a direct cytotoxicity test which used failure to attach after treatment with antiviral serum and complement as a measure of cytotoxicity. Cells infected with herpesvirus, as well as uninfected cells, were found to settle out of suspension and attach to the surface of containers within one hour after suspension. Infected cells appeared to be damaged by serum-complement treatment and were unable to attach. Immune cytotoxicity was found to be complement-dependent, since either omission or heating of the normal rabbit serum used as a source of complement eliminated the cytotoxic effect. Cell susceptibility to cytotoxic effects was found to be directly related to viral multiplicity of infection and presumably, therefore, to the proportion of infected cells. Infected cells were not susceptible during the first four hours after viral infection, but developed this susceptibility within 5–6 hours after infection. Anti-serum produced b..." @default.
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- W2068511052 date "1972-12-01" @default.
- W2068511052 modified "2023-09-26" @default.
- W2068511052 title "Study of Immune Cytotoxicity with Herpesvirus hominis Infected Cells" @default.
- W2068511052 doi "https://doi.org/10.3181/00379727-141-36866" @default.
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