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• W2068511668 abstract "Collagen/calcium phosphate scaffolds have been used for bone reconstruction due to their inherent similarities to the bone extracellular matrix. Calcium phosphate alone has also been used as a non-viral vector for gene delivery. The aim of this study was to determine the capability of a collagen/calcium phosphate scaffold to deliver naked plasmid DNA and mediate transfection in vivo. The second goal of the study was to deliver a plasmid encoding vascular endothelial growth factor165 (pVEGF165) to promote angiogenesis, and hence bone formation, in a mouse intra-femoral model. The delivery of naked plasmid DNA resulted in a 7.6-fold increase in mRNA levels of β-Galactosidase compared to the delivery of plasmid DNA complexed with a partially degraded PAMAM dendrimer (dPAMAM) in a subcutaneous murine model. When implanted in a muirne intra-femoral model, the delivery of pVEGF165 resulted in a 2-fold increase in bone volume at the defect site relative to control scaffolds without pVEGF165. It was concluded that a collagen/calcium phosphate scaffold can mediate transfection without the use of additional transfection vectors and can promote bone formation in a mouse model via the delivery of pVEGF165." @default.
• W2068511668 created "2016-06-24" @default.
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• W2068511668 date "2010-04-01" @default.
• W2068511668 modified "2023-10-17" @default.
• W2068511668 title "The ability of a collagen/calcium phosphate scaffold to act as its own vector for gene delivery and to promote bone formation via transfection with VEGF165" @default.
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• W2068511668 doi "https://doi.org/10.1016/j.biomaterials.2009.12.041" @default.
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